|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 2 | Regulation of intestinal permeability: The role of proteases显示文摘The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. | Hanne Van Spaendonk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter | 2017 | World Journal of Gastroenterology2017，23，12： | 6 |
| 3 | Sa1922 Pilot Study on the Safety and Efficacy of Faecal Microbiota Transplantation in Refractory Crohn’s Disease显示文摘 | Severine Vermeire Marie Joossens Kristin Verbeke Falk Hildebrand Kathleen Machiels Karolien Van den Broeck Gert Van Assche Paul J. Rutgeerts Jeroen Raes | 2012 | Gastroenterology2012，，5： | 2 |
| 4 | Dietary salt,nitrate and stomachcancer mortality in 24 countries 显示文摘 | Joossens JV Hill MJ Elliott P | 1996 | Int J Epidemiology1996，25，3： | 1 |
| 5 | Toll-like receptor-I, -2, and-6 polymorphisms influence disesse extension in inflammatory bowel disease显示文摘 | Pierk M Joossens S Van Steen K | 2006 | Inflarrun Bowel Dis2006，12，1： | 1 |
| 6 | Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease显示文摘 | Esters N Vermeire S Joossens S | 2002 | Am J Gastroenterol2002，97，6： | 1 |
| 7 | Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin (( 2S )-{ acetyl I -pyrrolidine-2- carbonitrile) 显示文摘 | Inger Brandt Jurgen Joossens Xin Chen | 2005 | Biochem Pharmacol2005，70，1： | 1 |
| 8 | Pilot study on the safety and efficacy of faecal microbiota transplantation in refractory Crohns disease 显示文摘 | Vermeire S Joossens M Verbeke K | 2012 | Gastroenterology2012，142，51： | 1 |
| 9 | The value of serologic markers in indeterminate colitis: A prospective follow-up study显示文摘 | Sofie Joossens Walter Reinisch Séverine Vermeire Boualem Sendid Daniel Poulain Marc Peeters Karel Geboes Xavier Bossuyt Peggy Vandewalle Georg Oberhuber Harald Vogelsang Paul Rutgeerts Jean-Frédéric Colombel | 2002 | Gastroenterology2002，，： | 1 |
| 10 | Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected rela- tives显示文摘 | Joossens M Huys G Cnockaert M | 2011 | Gut2011，60，： | 1 |
| 11 | Toll-Like receptor-1,-2,and -6 polymorphisms influence disease extension in inflammatory bowel diseases显示文摘 | Pierik M Joossens S Steen KV | 2006 | Inflamm Bowel Dis2006，12，1： | 1 |
| 12 | The value of serologic markers in indeterminate colitis: a prospective follow-up study 显示文摘 | JOOSSENS S REINISCH W VERMEIRE S | 2002 | Gastroenterology2002，122，5： | 1 |
| 13 | Anti-α-enolase antibodies in patients with inflammatory bowel disease 显示文摘 | Vermeulen N Arijs I Joossens S | 2008 | Clin Chem2008，54，3： | 1 |
| 14 | Diagnostic value of anti- Saccharorayces cerevisiae and antineutrophil cytoplasmic autoantibod- ies in inflammatory bowel disease 显示文摘 | Peeters M Joossens S Vermeire S | 2001 | Am J Gastroenterol2001，96，3： | 1 |
| 15 | The Tobacco Control Scale : a new scale to measure country activity显示文摘 | Joossens L Raw M | 2006 | Tob Control2006，15，3： | 1 |
| 16 | Mannan binding lectin (MBL) gene polymorphisms are not associated with anti-Saccharomyces cerevisiae(ASCA) in patients with Crohn' s disease显示文摘 | Joossens S Pierik M Rector A | 2006 | Gut2006，55，5： | 1 |
| 17 | Mass ciguatera poisoning after eating barracuda in Mexico: prognostic and therapeutic implications显示文摘 | De Haro L Hayek Lanthois M Joossen F | 1997 | Med Trop (Mass)1997，57，1： | 1 |
| 18 | Dysbiosis of the faecal microbiota in patients with Crohn' s disease and their unaffect- ed relatives显示文摘 | JOOSSENS M HUYS G CNOCKAERT M | 2011 | Gut2011，60，5： | 1 |
| 19 | The value of serologic markers in indeterminate colitis:a prospective follow-up study显示文摘 | Joossens S Reinisch W Vermeire S | 2002 | Gastroenterology2002，122，5： | 1 |
| 20 | New serological markers in inflammatory bowel disease are associated with compli- cated disease behaviour显示文摘 | Ferrante M Henckaerts L Joossens M | 2007 | Gut2007，56，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员