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| 1 | Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy显示文摘Mesenchymal stem cells(MSCs) are a pleiotropic population of cells that are self-renewing and capable of differentiating into canonical cells of the mesenchyme, including adipocytes, chondrocytes, and osteocytes. They employ multi-faceted approaches to maintain bone marrow niche homeostasis and promote wound healing during injury. Biomedical research has long sought to exploit their pleiotropic properties as a basis for cell therapy for a variety of diseases and to facilitate hematopoietic stem cell establishment and stromal reconstruction in bone marrow transplantation. Early results demonstrated their usage as safe, and there was little host response to these cells. The discovery of their immunosuppressive functions ushered in a new interest in MSCs as a promising therapeutic tool to suppress inflammation and down-regulate pathogenic immune responses in graft-versus-host and autoimmune diseases such as multiple sclerosis, autoimmune diabetes, and rheumatoid arthritis. MSCs produce a large number of soluble and membrane-bound factors, some of which inhibit immune responses. However, the full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease. The present review describes the large body of literature that has been accumulated on the fascinating biology of MSCs and their complex effects on immune responses. | Justin D Glenn Katharine A Whartenby | 2014 | World Journal of Stem Cells2014，6，5： | 55 |
| 2 | Management and prevention of acute and chronic lateral ankle instability in athletic patient populations显示文摘Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance. | Brendan J Mc Criskin Kenneth L Cameron Justin D Orr Brian R Waterman | 2015 | World Journal of Orthopedics2015，6，2： | 20 |
| 3 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 4 | Method for rapid on-site identification of VOCs显示文摘Rapid on-site identification of volatile organic compounds (VOCs) in ambient air is an important first step in remediation efforts. This study describes modification of a commercially available, portable GC/MS system and development of an analysis protocol for rapid (< 3 min) sampling and identification of VOCs typically found at contaminated sites at the low ppbv level. | Justin D Fair William F Bailey Robert A Felty Amy E Gifford Benjamin Shultes Leslie H Volles | 2009 | Journal of Environmental Sciences2009，21，7： | 8 |
| 5 | Fluoroscopically assisted pedicle screw fixation for thoracic and thoracolumbar injuries显示文摘 | John J Carbone M D Justin P | 2003 | SPINE2003，28，1： | 1 |
| 6 | Algal esterase activity as a biomeasure of environmental degradation in a freshwater creek显示文摘 | Rudi H Regel John M Ferris George G Ganf Justin D Brookes | 2002 | Aquatic Toxicology2002，，3： | 1 |
| 7 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 8 | Temporal contiguity between food ingestion and toxicosis affects the acquisition of food aversions in sheep显示文摘 | Frederick D Provenza John V Nolan Justin J Lynch | 1993 | Applied Animal Behaviour Science1993，38，12： | 1 |
| 9 | Enzymatic hydrolysis of cuttlefish (Sepia officinalis) and sardine (Sardina pilchardus) viscera using commercial proteases: effects on lipid distribution and amino acid composition 显示文摘 | Emna S K Justine D Claire D M | 2009 | Journal of Bioscience and Bioengineering2009，107，2： | 1 |
| 10 | The influence of light and nutrients on buoyancy,filament agreegation and flotation of Anabaena circinalis显示文摘 | JUSTIN D B GEORGE G G DAMIAN G | 1999 | Journal of Plankton Research1999，21，2： | 1 |
| 11 | Long-term differences in urinary, bowel and sexual function among men treated with surgery versus radiation for prostate cancer显示文摘 | Justin D EHett James S Rosoff Sandip M Prasad | 2013 | Asian Journal of Andrology2013，15，4： | 1 |
| 12 | Investigating the technical, economic and environmental performance of electric vehicles in the real-world: A case study using electric scooters显示文摘 | JUSTIN D K DOUCETTE R T ROBINSON D | 2011 | Journal of Power Sources2011，196，10： | 1 |
| 13 | Elderly patient with small bow- el volvulus 显示文摘 | Justin A Snyder D O | 2010 | J Am Osteopath Assoe2010，110，11： | 1 |
| 14 | The intramedullary skele tal kinetic distractor(ISKD) first cinical results of a new intramedullary neil for lengthing of the femur and tibia 显示文摘 | Cole JD Justin D KasparisT | 2003 | Injury2003，14，： | 1 |
| 15 | Variations in the buoyancy response of Microcystis aeruginosa to nitrogen,phosphorus and light显示文摘 | JUSTIN D B GEORGE G G | 2001 | Journal of Plankton Research2001，23，12： | 1 |
| 16 | Valuing Cultural Differences in Be- havioral Economics显示文摘 | Justin D Levinson Kaiping Peng | 2007 | The ICFAI Journal of Behavioral Finance2007，，1： | 1 |
| 17 | Linking migration, mobility and HIV显示文摘 | Kevin D Dearie Justin O | 2010 | Tropical Medicine and International Health2010，15，12： | 1 |
| 18 | A 576-Year Weber River Streamflow Reconstruction from Tree Rings for Water Resource Risk Assessment in the Wasatch Front, Utah 显示文摘 | Bekker M F Justin D R Buckley B M | 2014 | Journal of the American Water Resources Association2014，50，5： | 1 |
| 19 | Detection of intensification in global-and continental-scale hydrological cycles: Temporal scale of evaluation 显示文摘 | Alan D Z Justin S Edwin P M | 2003 | Journal of Climate2003，16，： | 1 |
| 20 | Vibrational spectroscopy:recent developments to revolutionize forensic science显示文摘 | Claire K M Kyle C D Justin B | 2015 | Anal Chem2015，87，： | 1 |
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