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| 1 | The role of peroxisome proliferator-activated receptor gamma in prostate cancer显示文摘 | Catherine Elix Sumanta K Pal Jeremy O Jones | 2018 | Asian Journal of Andrology2018，20，3： | 7 |
| 2 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 3 | 作为医学人文教育核心的历史学显示文摘尝试从不同的角度讨论史学对于医学核心能力在知识、论证和操作上所发挥的作用。史学对于了解疾病的成因(如非还原论机制需要计算疾病长期以来的变化量)、疗效(如为什么医生认为他们的治疗方案有效,还有就是他们在不同时期的评估方式的变化)有核心贡献。同时有助于了解医学知识和实际操作在不同的社会、经济和政治背景中的偶然性。这些都是医生作为诊断者和治疗者需要知道的。因此史学恰恰能被纳入医学教育中最为盛行的核心技能的培养。 | 方芗(译) | 2018 | 广西民族大学学报(哲学社会科学版)2018，40，2： | 3 |
| 4 | A systematic review of the clinical effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus显示文摘 | Jim Chilcott Paul Tappenden Myfanwy Lloyd Jones Jeremy P. Wight | 2001 | Clinical Therapeutics2001，，11： | 2 |
| 5 | Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization显示文摘 | Alexander N. Kapustin John D. Davies Joanne L. Reynolds Rosamund McNair Gregory T. Jones Anissa Sidibe Leon J. Schurgers Jeremy N. Skepper Diane Proudfoot Manuel Mayr Catherine M. Shanahan | 2011 | Circulation Research2011，，1： | 2 |
| 6 | CaU and The Responsibilities of Teachers and Administrators 显示文摘 | Jones Jeremy F | 2001 | ELT Journal2001，，： | 1 |
| 7 | Late uterine wedge resection of placenta increta显示文摘 | Jone S Jeremy SS Eric J | 1999 | Obstet Gynecol1999，94，： | 1 |
| 8 | Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis显示文摘 | Kieren G. Hollingsworth Julia L. Newton Roy Taylor Claire McDonald Jeremy M. Palmer Andrew M. Blamire David E.J. Jones | 2008 | Clinical Gastroenterology and Hepatology2008，，9： | 1 |
| 9 | gene expression profiling and genetic markers in glioblastoma survival显示文摘 | Jeremy N Rich Christopher Hans Beatrix Jones | 2005 | Cancer Res2005，65，10： | 1 |
| 10 | A Global Profile of Germline Gene Expression in C. elegans显示文摘 | Valerie Reinke Harold E. Smith Jeremy Nance John Wang Carrie Van Doren Rebecca Begley Steven J.M. Jones Elizabeth B. Davis Stewart Scherer Samuel Ward Stuart K. Kim | 2000 | Molecular Cell2000，，3： | 1 |
| 11 | CALL and the responsibilities of teachers and administrators显示文摘 | Jeremy F | 2001 | ELT Journal2001，，： | 1 |
| 12 | Why wait for fieldbus显示文摘 | | 1992 | C&I1992，4，： | 1 |
| 13 | CALL and the responsibilities of teachers and administrators显示文摘 | Jeremy F | 2001 | ELT Journal2001，554，： | 1 |
| 14 | Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates显示文摘 | Jeremy A. Miller Jason Nathanson Daniel Franjic Sungbo Shim Rachel A. Dalley Sheila Shapouri Kimberly A. Smith Susan M. Sunkin Amy Bernard Jeffrey L. Bennett Chang-Kyu Lee Michael J. Hawrylycz Allan R. Jones David G. Amaral Nenad Sestan Fred H. Gage Ed S. | 2013 | Development2013，，22： | 1 |
| 15 | Laser spectroscopic study of photoinduced picosecond processes in amorphous and polycrystalline silicon films 显示文摘 | Kubinyi M Grofcsik A Jeremy Jones W | 1997 | Mol Struct1997，408，： | 1 |
| 16 | Cavernosal dysfunction in a rabbit model of hyperhomocysteinaemia显示文摘 | Jones RW Jeremy JY Koupparis A | 2005 | BJU Int2005，95，1： | 1 |
| 17 | CALL and The Responsibilities of Teachers and Administrators 显示文摘 | Jones Jeremy F | 2001 | EL T Journal2001，，4： | 1 |
| 18 | CALL and the responsibilities of teachers and administrators 显示文摘 | Jeremy F jones | 2001 | ELT Journal2001，，： | 1 |
| 19 | CALL and the responsibilities of teachers and administrators 显示文摘 | Jones Jeremy F | 2001 | ELT Journal2001，，5： | 1 |
| 20 | Late uterine wedge resection of placenta inereta 显示文摘 | Jone S Jeremy SS Erie J | 1999 | Obstet Gynecol1999，94，2： | 1 |
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