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| 1 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 2 | Amyloid beta: structure, biology and structure-based therapeutic development显示文摘淀粉的贝它肽(A) 通过 transmembrane 蛋白质的解朊的处理被生产,淀粉的先锋蛋白质(应用软件) ,由 - 并且 -secretases。在大脑的累积被建议是在 Alzheimers 疾病的致病的一个早有毒的事件,它是在大脑与匾和混乱联系的痴呆的最普通的形式。当前, A 的生理、病理学的形式是什么,是不清楚的并且由由什么机制, A 引起痴呆。而且,没有有效的药停止或逆行 Alzheimers 的前进疾病。在这份报纸,我们考察 A 的结构,生物功能,和 neurotoxicity 角色。我们也讨论与 A 交往并且调停的潜在的受体吸入,清理,和新陈代谢。另外,我们为治疗 Alzheimers 疾病总结治疗学的开发和不同策略的最近的进展。最后,我们将在象为 Alzheimers 疾病的治疗答应策略选择一样寻找新奇、潜在地有效的代理人在进步上报导。这些前景包括对 A,它的受体和字形物蛋白质起作用的代理人,例如对 A 的小分子,疫苗和抗体;禁止者或调节的人 - 并且 -secretase;降级 A 的朊酶;字形物蛋白质禁止者和疫苗;淀粉的染料和 microRNAs。 | Guo-fang CHEN Ting-hai XU Yan YAN Yu-ren ZHOU Yi JIANG Karsten MELCHER H Eric XU | 2017 | Acta Pharmacologica Sinica2017，38，9： | 39 |
| 3 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 4 | Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death显示文摘 | Jiang H Gomez-Manzano C Aoki H Alonso MM Kondo S McCormick F Xu J Kondo Y Bekele BN Colman H Lang FF Fueyo J | 2007 | 中国神经肿瘤杂志2007，5，3： | 24 |
| 5 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 6 | EZH2: biology, disease, and structure-based drug Jiscovery显示文摘 | Jin-zhi TAN Yan YAN Xiao-xi WANG Yi JIANG H Eric XU | 2014 | Acta Pharmacologica Sinica2014，35，2： | 21 |
| 7 | Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload显示文摘 | Jiang H Luan Z Wang J Xie J | 2006 | 中国生物学文摘2006，20，10： | 18 |
| 8 | Study on the risk factors of lymphatic metastasis and the indications of less invasive operations in early gastric cancer显示文摘INTRODUCTIONThe principle of surgical treatment for gastric cancer is theradical resectioning although the suitable resetting range fordifferent cases of gastric cancer is still being arguedupon.However,the diagnostic accuracy of | Jiang BJ Sun RX Lin H Gao YF | 2000 | World Journal of Gastroenterology2000，6，4： | 15 |
| 9 | Study of T-lymphocyte subsets,nitric oxide,hexosamine and Helicobacter pylori infection in patients with chronic gastric diseases显示文摘INTRODUCTIONChronic gastritis(CG)and peptic ulcer(PU)arefrequently-occurring diseases.It is now well recognizedthat Helicobacter pylori(Hp)is a major factor that leadsto CG and PU.In order to study the relationshipamong T lymphocyte subsets,NO,Hexosamine and | Zhang H Jiang SL Yao XX | 2000 | World Journal of Gastroenterology2000，6，4： | 10 |
| 10 | Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells显示文摘 | Zhong, X. S. Liu, L. Z. Skinner, H. D. Cao, Z. X. Ding, M. Jiang, B. H | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 8 |
| 11 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 12 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 13 | 麝香保心丸对血管平滑肌细胞表型转化的影响显示文摘目的:观察麝香保心丸(SXBXW)对血管平滑肌细胞表型转化的影响。方法:以血管平滑肌细胞系RASMCP8为模型,设对照组,SXBXW0.25、0.5、1.0和2.0g/L组,经不同浓度的SXBXW作用后,用流式细胞术测定RASMCP8细胞的收缩型特异性分子标志物α-平滑肌肌动蛋白(α-SMA)和平滑肌肌球蛋白重链(SM-MHC)表达的变化。结果:与对照组相比,经SXBXW处理后,α-SMA和SM-MHC的阴性细胞百分比降低,阳性细胞百分比增加。结论:SXBXW能促使血管平滑肌细胞的表型从合成型向收缩型转化。 | 车贤达 Simon X Liang Xingmai Jiang 高瑞兰 张庆刚 钱琳艳 赵嫣 Beng H Chong | 2010 | 中国病理生理杂志2010，26，11： | 6 |
| 14 | 麝香保心丸对血管平滑肌细胞表型转化和增殖的影响显示文摘目的:观察麝香保心丸(SXBXW)对血管平滑肌细胞表型转化和增殖的影响。方法:培养平滑肌细胞系RASMC P8细胞并将其分成对照组和SXBXW药物组。并观察SXBXW对细胞增殖、增殖周期、对血管平滑肌α-平滑肌肌动蛋白(α-SMA)和肌球蛋白重链(SM-MHC)表达的影响。结果:麝香保心丸抑制RASMC P8细胞由收缩型向合成型转化,表现为收缩型细胞的标志物α-SMA和SM-MHC标记的阳性细胞增加,阴性细胞减少,同时抑制RASMC P8细胞周期从G1期向S期转化,从而抑制细胞的增殖。结论:SXBXW能有效的抑制血管平滑肌的细胞表型转化和细胞增殖。 | 张庆刚 高瑞兰 Beng H Chong Simon X Liang Xingmai Jiang 车贤达 | 2014 | 中华中医药学刊2014，32，4： | 5 |
| 15 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 16 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 17 | The Photochemical Study of HSA and BSA with Resonance Light Scattering and Fluorescence Spectra显示文摘The resonance light-scattering (RLS) of human serum albumin (HSA) and bovine serum albumin (BSA) is reported for the first time, and applied to study photochemical reaction of HSA and BSA. The fact of photocrosslinking self-association effect in HSA and BSA solutions is identified by the enhancement of RLS. The fluorescence quenching at about 350 um and 700 um proves that tryptophan (Trp) residues are one of the photochemical activity sites in HSA and BSA molecules. The Rayleigh scattering (RS) spectra of HSA and BSA that were neglected in fluorescence spectra before are found at about 296 um, 592 um and 888 um for the first time, and are of adventageous to studying the aggregation of HSA or BSA. The possible photochemical reaction mechanism is also proposed. | Liang, H Shen, XC Li, F Jiang, ZL | 2000 | Chinese Chemical Letters2000，11，3： | 4 |
| 18 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 19 | 血浆7-酮胆固醇与冠状动脉疾病患者心血管结局和总死亡率的关系显示文摘7-酮胆固醇(7-ketocholesterol,7-KC)是胆固醇氧化产物的一种形式,在动物动脉粥样硬化模型的形成中起重要作用。该文研究人员试图确定循环7-KC与稳定型冠状动脉疾病(coronary artery disease,CAD)患者的临床心血管结局和总死亡率的关系。 | 刘莉 叶鹏 Song J Wang D Chen H Huang X Zhong Y Jiang N Chen C Xia M | 2017 | 中华高血压杂志2017，25，6： | 4 |
| 20 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
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