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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Growth and characterization of 0.8-μm gate length AlGaN/GaN HEMTs on sapphire substrates显示文摘AlGaN/GaN high electron mobility transistor (HEMT) structures were grown on 2 inch sapphire substrates by MOCVD, and 0.8-μm gate length devices were fabricated and measured. It is shown by resistance mapping that the HEMT structures have an average sheet resistance of approximately 380 ?/sq with a uniformity of more than 96%. The 1-mm gate width devices using the materials yielded a pulsed drain current of 784 mA/mm at Vgs=0.5 V and Vds=7 V with an extrinsic transconductance of 200 mS/mm. A 20-GHz unity current gain cutoff frequency (?T ) and a 28-GHz maximum oscillation frequency (?max) were obtained. The device with a 0.6-mm gate width yielded a total output power of 2.0 W/mm (power density of 3.33 W/mm) with 41% power added efficiency (PAE) at 4 GHz. | WANG Xiaoliang WANG Cuimei HU Guoxin WANG Junxi RAN Junxue FANG Cebao LI Jianping ZENG Yiping LI Jinmin LIU Xinyu LIU Jian QIAN He | 2005 | Science in China(Series F)2005，48，6： | 7 |
| 3 | Decreased b-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes显示文摘The influence of b-cell function on cardiovascular autonomic neuropathy(CAN), an important diabetesrelated complication, is still unclear. In this study, we aimed to investigate the association between residual b-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. The patients were divided into a CAN? group(diabetic patients with CAN, n = 20) and a CAN-group(diabetic patients without CAN, n = 70) according to the standard Ewing battery of tests. Fasting and postprandial plasma glucose, insulin, and C-peptide were measured.Homeostasis model assessment-beta cells(HOMA-B) and HOMA-insulin resistance(IR) were calculated. The prevalence of CAN in this population was 22.2%. Compared with the CAN-group, the CAN? group had significantly lower fasting plasma insulin(6.60 ± 4.39 vs 10.45 ± 7.82 l/L, P = 0.029), fasting C-peptide(0.51 ± 0.20 vs0.82 ± 0.51 nmol/L, P = 0.004), and HOMA-B(21.44 ± 17.06 vs 44.17 ± 38.49, P = 0.002). Fasting C-peptide was correlated with the Valsalva ratio(r = 0.24, P = 0.043) and the 30:15 test(r = 0.26,P = 0.023). Further analysis showed that fasting C-peptide(OR: 0.041, 95% CI 0.003–0.501, P = 0.012) and HOMAB(OR: 0.965, 95% CI 0.934–0.996, P = 0.028) were independently associated with cardiovascular autonomic nerve function in this population. The patients with fasting C-peptide values \ 0.67 nmol/L were more likely to have CAN than those with C-peptide levels C0.67 nmol/L(OR:6.00, 95% CI 1.815–19.830, P = 0.003). A high prevalence of CAN was found in patients with newly-diagnosed type 2 diabetes. Decreased b-cell function was closely associated with CAN in this population. | Xubin Yang Wen Xu Yanhua Zhu Hongrong Deng Ying Tan Longyi Zeng Jianping Weng | 2019 | Neuroscience Bulletin2019，35，1： | 7 |
| 4 | High-pressure granulite from Western Kunlun,northwestern China:Its metamorphic evolution,zircon SHRIMP U-Pb ages and tectonic implication显示文摘High-pressure mafic granulites occurring as lenticular bodies within garnet-amphibolites in Kangxiwar Fault have been first reported in this paper. The P-T conditions of two metamorphic stages were ob-tained using calibrated geothermal barometers and ThermoCalc Program. The peak metamorphic con-dition of these high-pressure granulites is about 760―820℃,1.0―1.2 GPa and the retrograde meta-morphic condition is about 620―720℃,0.7―0.8 GPa. The petrological studies show that they have a near-isobaric cooling P-T path which suggests that the Western Kunlun underwent initial crustal thickening,subsequent exhumation and cooling. The SHRIMP zircon U-Pb dating gives two groups of ages for high-pressure granulites. One is 177±6 Ma which is obtained from the rim of the zircon. We consider this age should be the metamorphic age. And the other is 456±30 Ma which is obtained from the core of the zircon and should be the protolith age. The formation of these high-pressure granulites in western Kunlun is closely correlated with the evolution of the Paleo-Tethys and has important im-plications for the research on Tethys and Paleo-Asian tectonic zone. | QU JunFeng ZHANG LiFei AI YongLiang L Zeng WANG JianPing ZHOU Hui WANG ShiYan | 2007 | Science China Earth Sciences2007，50，7： | 7 |
| 5 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 6 | ^(234)Th/^(238)U disequilibrium and particulate organic carbon export in the northwestern South China Sea显示文摘234 Th was utilized as a tracer of particulate organic carbon (POC) export in the northwestern South China Sea (SCS) on the basis of the data collected at four stations during a spring cruise.Depth profiles of dissolved and particulate 234 Th activities were measured in the upper 60 m,showing a significant deficit relative to 238 U over the investigated stations.A stratified structure of 234 Th-238 U disequilibrium was in general observed in the upper 60 m water column,indicating that the euphotic zone of the northwestern SCS in this reason can be divided into two layers,an upper and lower layer,with different export rates.POC export fluxes were estimated from a one-dimensional steady state model of 234 Th fluxes in combination with the measurement of POC/ 234 Th ratios on suspended particles.The POC export in this region ranged from 8.2 to 20.0 mmol/(m 2 · d),with an average of 16.0 mmol/(m 2 · d),and was slightly higher than those previously reported in the southern SCS. | MA Hao ZENG Zhi YU Wen HE Jianhua CHEN Liqi CHENG Jianping YIN Mingduan ZENG Shi | 2011 | Acta Oceanologica Sinica2011，30，3： | 5 |
| 7 | A Robust Authentication Scheme for Filtering of Injected False Data in Dynamic Wireless Sensor Networks显示文摘 | HU Yupeng LIN Yaping YU Jianping ZENG Weini YI Yeqing LI Xiaolong | 2007 | Chinese Journal of Electronics2007，16，3： | 4 |
| 8 | Temporal-spatial characteristics of vegetation cover and desertification of China by using remote sensing data | XU Xingkui , LIN Zhaohui, LI Jianping and ZENG Qingcun(LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China) | 2002 | Progress in Natural Science:Materials International2002，12，1： | 4 |
| 9 | Pakl mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression显示文摘 | Kejing Zeng Lili Tian Adam Sirek Weijuan Shao Ling Liu Yu-Ting Chiang Jonathan Chernoff Dominic S. Ng Jianping Weng Tianru Jin | 2017 | Journal of Molecular Cell Biology2017，9，5： | 4 |
| 10 | Molecular phylogenetic analyses redefine seven major clades and reveal 22 new generic clades in the fungal family Boletaceae显示文摘Mushrooms in the basidiomycete family Boletaceae are ecologically and economically very important.However,due to the morphological complexity and the limited phylogenetic information on the various species and genera of this fungal family,our understanding of its systematics and evolution remains rudimentary.In this study,DNA sequences of four genes(nrLSU,tef1-α,rpb1,and rpb2)were newly obtained from ca.200 representative specimens of Boletaceae.Our phylogenetic analyses revealed seven major clades at the subfamily level,namely Austroboletoideae,Boletoideae,Chalciporoideae,Leccinoideae,Xerocomoideae,Zangioideae,and the Pulveroboletus Group.In addition,59 genus-level clades were identified,of which 22 were uncovered for the first time.These 22 clades were mainly placed in Boletoideae and the Pulveroboletus Group.The results further indicated that the characters frequently used in the morphology-based taxonomy of Boletaceae,such as basidiospore ornamentation,the form of the basidioma,and the stuffed pores each had multiple origins within the family,suggesting that the use of such features for high-level classification of Boletaceae should be de-emphasized and combined with other characters. | Gang Wu Bang Feng Jianping Xu Xue-Tai Zhu Yan-Chun Li Nian-Kai Zeng MdIqbal Hosen Zhu L.Yang | 2014 | Fungal Diversity2014，，6： | 4 |
| 11 | Enhancement of municipal sludge dewaterability by electrochemical pretreatment显示文摘Electrolysis is a promising technology to improve sludge dewaterability efficiently with negligible environmental impact. To intensify the electrolytic efficiency, the effect of electrolytes(NaCl, Na_2SO_4, NaNO_3, and NaClO_4) on electrolysis pretreatment of municipal sludge and its mechanisms was investigated using Ti/PbO_2 electrodes. The electrolytes,which enhanced the production of oxidative radicals, showed a significant synergetic effect in reducing the capillary suction time(CST) of sludge. NaCl was distinguished from the other electrolytes since it formed a large amount of active chlorine species, which oxidized the sludge cells to improve the sludge dewaterability. The surface morphologies as well as the soluble proteins and polysaccharides were analyzed to unravel the underlying mechanisms of sludge dewaterability. Additionally, an economic assessment showed that NaCl addition in the electrolysis pretreatment can be a suitable technique for enhancing municipal sludge dewaterability. | Ke Xiao Jianping Deng Li Zeng Tao Guo Yan Gong Bo Yang Xu Zhao Huabo Duan | 2019 | Journal of Environmental Sciences2019，31，1： | 3 |
| 12 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 13 | Cross-calibration on the electromagnetic field detection payloads of the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic Satellite(CSES)deploys three payloads to detect the electromagnetic environment in the ionosphere.The tri-axial fluxgate magnetometers(FGM),as part of the high precision magnetometer(HPM),measures the Earth magnetic vector field in a frequency range from direct current(DC)to 15 Hz.The tri-axial search coil magnetometer(SCM)detects the alternating current(AC)related magnetic field in a frequency range from several Hz to 20 k Hz,and the electric field detector(EFD)measures the spatial electric field in a broad frequency band from DC to 3.5 MHz.This work mainly crosscalibrates the consistency of these three payloads in their overlapped detection frequency range and firstly evaluates CSES’s timing system and the sampling time differences between EFD and SCM.A sampling time synchronization method for EFD and SCM waveform data is put forward.The consistency between FGM and SCM in the ultra-low-frequency(ULF)range is validated by using the magnetic torque(MT)signal as a reference.A natural quasiperiodic electromagnetic wave event verifies SCM and EFD’s consistency in extremely low-frequency and very low-frequency(ELF/VLF)bands.This cross-calibration work is helpful to upgrade the data quality of CSES and brings valuable insights to similar electromagnetic detection solutions by low earth orbit satellites. | ZHIMA Zeren ZHOU Bin ZHAO ShuFan WANG Qiao HUANG JianPing ZENG Li LEI JunGang CHEN Yu LI Cheng YANG DeHe SUN XiaoYing MIAO YuanQing ZHU XingHong SHEN XuHui | 2022 | Science China(Technological Sciences)2022，65，6： | 3 |
| 14 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 15 | Trace Element Compositions of Pyrite from the Shuangwang Gold Breccias,Western Qinling Orogen,China:Implications for Deep Ore Prediction显示文摘The Shuangwang gold deposit, located in the Fengxian-Taibai fore-arc basin in the western Qinling Orogen of Central China, has yielded over 70 tons of gold. It is an orogenic gold deposit occurring in an NW-trending breccia belt. Most of the ores are hydrothermal breccia type containing fragments of adjacent strata cemented by ankerite and pyrite. Pyrite is the most abundant metallic mineral and the major gold-bearing mineral in the ores. A total of 58 pyrite samples from main ore bodies of the Shuangwang gold deposit have been analysed for 44 trace elements by HR-ICP-MS. Sb, Ba, Cu, Pb, Zn, Bi, Mo, Co are selected as indicator elements to investigate the potential usefulness of trace elements in pyrite as an indicator in gold exploration. The results show that the supra-ore halo elements Sb and Ba, which may have been more active than other near-ore halo elements and sub-ore halo elements, are best to characterize the shape of ore bodies. Five target areas are pointed out for deep ore exploration based on a comprehensive study of supra-ore, near-ore and sub-ore halos. This study provides evidence that trace elements in pyrite can be used to depict the deep extension of ore bodies and to vector towards undiscovered ore bodies. | Jianping Wang Zhenjiang Liu Jiajun Liu Xiangtao Zeng Kexin Wang Bizheng Liu Huan Wang Chonghao Liu Fangfang Zhang | 2018 | Journal of Earth Science2018，29，3： | 3 |
| 16 | Precision in Liver Surgery显示文摘 | Jiahong Dong ShiZhong Yang Jianping Zeng Shouwang Cai Wenbin Ji Weidong Duan Aiqun Zhang Weizheng Ren Yinzhe Xu Jingwang Tan Xiangyang Bu Ning Zhang Xuedong Wang Xianqiang Wang Xiangfei Meng Kai Jiang Wanqing Gu Zhiqiang Huang | 2013 | Semin Liver Dis2013，，03： | 2 |
| 17 | Tomographic SAR imaging with large elevation aperture: a P-band small UAV demonstration显示文摘Elevation resolution is an important indicator in tomographic SAR imaging as it represents the ability to discriminate closed targets in elevation. In general, the elevation resolution is proportional to the length of the elevation aperture. However, as the elevation aperture increases, the geometric consistency of the image will undesirably deteriorate and hence fails the image coregistration approach required by the traditional super-resolution tomographic imaging. In this paper, a new super-resolution tomographic imaging method is proposed to overcome the inconsistency problem caused by the large elevation aperture. The core strategy is to get rid of two-dimensional image coregistration by applying a three-dimensional(3 D) back projection like imaging manner: the 3 D space is firstly divided into a 3 D imaging grid, each of which is individually imaged via compressive sensing for super-resolution. The effectiveness of the proposed approach is evaluated by both computer simulations and real P-band UAV SAR data. | Tao ZENG Minkun LIU Yan WANG Zegang DING Linghao LI Zhen WANG Yangkai WEI Jianping WANG | 2022 | Science China(Information Sciences)2022，65，3： | 2 |
| 18 | China Seismo-Electromagnetic Satellite search coil magnetometerdata and initial results显示文摘Four levels of the data from the search coil magnetometer(SCM) onboard the China Seismo-Electromagnetic Satellite(CSES)are defined and described. The data in different levels all contain three components of the waveform and/or spectrum of the induced magnetic field around the orbit in the frequency range of 10 Hz to 20 kHz; these are divided into an ultra-low-frequency band(ULF,10–200 Hz), an extremely low frequency band(ELF, 200–2200 Hz), and a very low frequency band(VLF, 1.8–20 kHz). Examples of data products for Level-2, Level-3, and Level-4 are presented. The initial results obtained in the commission test phase demonstrated that the SCM was in a normal operational status and that the data are of high enough quality to reliably capture most space weather events related to low-frequency geomagnetic disturbances. | Qiao Wang JianPing Huang XueMin Zhang XuHui Shen ShiGeng Yuan Li Zeng JinBin Cao | 2018 | Earth and Planetary Physics2018，2，6： | 2 |
| 19 | Antibiotic drugs targeting bacterial RNAs显示文摘RNAs have diverse structures that include bulges and internal loops able to form tertiary contacts or serve as ligand binding sites.The recent increase in structural and functional information related to RNAs has put them in the limelight as a drug target for small molecule therapy.In addition,the recognition of the marked difference between prokaryotic and eukaryotic rRNA has led to the development of antibiotics that specifically target bacterial rRNA,reduce protein translation and thereby inhibit bacterial growth.To facilitate the development of new antibiotics targeting RNA,we here review the literature concerning such antibiotics,mRNA,riboswitch and tRNA and the key methodologies used for their screening. | Weiling Hong Jie Zeng Jianping Xie | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 2 |
| 20 | Serum trimethylamine-N-oxide and gut microbiome alterations are associated with cholesterol deposition in the liver of laying hens fed with rapeseed meal显示文摘Sinapine derived from cruciferous plants could be converted into trimethylamine by intestinal microbiota.Its metabolite,trimethylamine N-oxide(TMAO),is closely linked to increased risk of cardiovascular disease and fat deposition in mammals.Hens fed with rapeseed meal(RSM)suffered from fatty liver hemorrhage syndrome(FLHS).This study was conducted to investigate whether RSM-induced fatty liver is due to TMAO via altering microbiota composition and diversity.At 33 weeks of age,600 laying hens were randomly divided into 5 treatment groups,namely control and 14%RSM treatment groups(DY5,with 16.2% erucic acid [EA]and 74.66% glucosinolate[Gl]contents;MB1,with 3.50% EA and 43.23 %Gl contents;DY6,with 6.7% EA and 22.67% Gl contents;XH3,with 44.60% EA and 132.83% Gl contents)for 8 weeks.Results revealed that 3 hens died due to liver hemorrhage after ingesting 14% RSM diet.The 14% RSM decreased serum low-density lipoprotein cholesterol(LDL-C)content(P<0.01)while tended to increase serum TMAO content compared to the control group(P=0.08).The 14% RSM diet increased red oil O optical density(P<0.01),and increased total cholesterol(TC)and LDL-C content in the liver(P<0.01,and P<0.01,respectively).The 14%RSM decreased liver total bile acid(TBA)content compared to the control(P<0.01).The DY6 had a higher TBA content in the liver than the XH3(P<0.01).The 14%RSM decreased mRNA abundance of liver X receptors alpha(LXR-α,P=0.01),and increased mRNA abundance of sterol response element binding protein 2(SREBP-2,P=0.04).Results revealed that the in-feed RSM could alter richness and diversity of cecal microbiota compared to the control(P<0.05).Liver TC content and serum TMAO showed a negative relationship with Proteobacteria and Actinobacteria(P=0.04).In conclusion,14%RSM increased liver TC and induced high liver score of FLHS,which was possibly associated with the altered cecal microbiota composition,increased serum TMAO levels and LXR-αand SREBP-2 expressions. | Liping Zhu Jianping Wang Xuemei Ding Shiping Bai Qiufeng Zeng Yue Xuan Gregory S.Fraley Keying Zhang | 2021 | Animal Nutrition2021，，4： | 2 |
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