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| 1 | Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘 | Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG | 2013 | Acta Pharmacologica Sinica2013，34，1： | 26 |
| 2 | Mushroom Poisoning Outbreaks-China,2020显示文摘What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population.The most notorious lethal mushrooms are the species from genera Amanita,Lepiota,and Galerina that cause acute liver failure,and Russula subnigricans that leads to rhabdomyolysis.What is added by this report?In 2020,the total number of investigations reached 676,involving an estimated 102 species of poisonous mushrooms,24 of which were newly recorded in China.Gyromitra venenata was newly discovered in incidents in Yunnan and Guizhou provinces and were the first reported poisonings due to gyromitrins in China since 2000.The rare poisoning Shiitake mushroom dermatitis was recorded in China.Hemolysis poisoning caused by Paxillus involutus was recorded for the second time since the beginning of the new century,resulting in one death in Inner Mongolia Autonomous Region.What are the implications for public health practice?Promoting knowledge about safe consumption of mushrooms is essential to reduce mushroom poisonings.It is not wise to collect and eat wild mushrooms.For southwestern provinces such as Yunnan,especially,caution must be exercised with unfamiliar mushroom species. | Haijiao Li Hongshun Zhang Yizhe Zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma Yutao Zhang Ke Wen Yuan Yuan Nan Lang Bowen Cheng Junjia Lu Chengye Sun | 2021 | China CDC weekly2021，3，3： | 13 |
| 3 | Mushroom Poisoning Outbreaks--China,2019显示文摘What is already known about this topic?Mushroom poisoning is becoming one of the most serious food safety issues in China,which is responsible for nearly a half of all oral poisoning deaths.What is added by this report?In China,many mushrooms were previously“recorded”as poisonous.In this study,about 70 species obtained from mushroom poisoning incidents including several new records were confirmed accurately by morphological and molecular evidence in 2019,and spatial and temporal distribution characters of 13 lethal mushrooms were summarized systematically.What are the implications for public health practice?Precise and timely species identification is of pivotal importance in mushroom incidents.More efforts and cooperation are continued to be needed urgently for the governments,CDC staff,doctors and mycologists in future. | Haijiao Li Hongshun Zhang Yizhe Zhang Kaiping Zhang Jing Zhou Yu Yin Shaofeng Jiang Peibin Ma Qian He Yutao Zhang Ke Wen Yuan Yuan Nan Lang Junjia Lu Chengye Sun | 2020 | China CDC weekly2020，2，2： | 11 |
| 4 | Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease显示文摘 | Yun-Dai CHEN Wei-Yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI Zhu-Jun SHEN Jing WANG Yi-Ning WANG Lei XU Li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI | 2018 | Journal of Geriatric Cardiology2018，15，1： | 10 |
| 5 | Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study显示文摘This study compared HPV testing and liquid-based cytology(LCT)as performance indicators for cervical cancer screening in a hospital-based study.A total of 61,193 outpatients were screened initially by LCT.Samples with screening results showing atypical squamous cells of undetermined significance(ASC-US)or worse were referred for colposcopy,and some | YANG Yi LANG Jing He WANG You Fang CHENG Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG Rui Fen | 2015 | Biomedical and Environmental Sciences2015，28，1： | 10 |
| 6 | High value of controlled attenuation parameter predicts a poor antiviral response in patients with chronic hepatits B显示文摘BACKGROUND:Controlled attenuation parameter(CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography.The objective of this study was to investigate the effect of high value of CAP on antiviral therapy in patients with chronic hepatitis B(CHB).METHODS:Patients with CHB receiving enticavir for initial antiviral therapy were studied;they were divided into the high CAP group and normal CAP group at baseline according to the CAP values.The effect of the antiviral therapy between the two groups were compared at week 12,24 and 48.Patients with high CAP value at baseline were divided into three subgroups,mild,moderate and severe elevation;the therapeutic response were compared among patients with normal CAP and subgroups of patients with elevated CAP.RESULTS:A total of 153 patients were enrolled.Among them,63 were in the high CAP group and 90 in the normal CAP group.Patients with high CAP had lower rates of ALT normalization and HBV DNA clearance in response to antiviral therapy compared with those with normal CAP at week 12,24 and 48.Further analysis showed that the rate of ALT normalization in patients with mildly and moderately elevated CAP were significant lower than those with normal CAP at week 12 and 24;while the difference was not significant between the patients with normal CAP and those with severely elevated CAP.The rate of HBV DNA clearance was significantly lower in patients with severely elevated CAP compared with those with normal CAP at week 12,24 and 48.CONCLUSION:CHB patients with high CAP had poor response to antiviral therapy. | Jing Chen Meng-Lan Wang Qin Long Lang Bai Hong Tang | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 9 |
| 7 | 健康老年妇女近段股骨骨密度和结构的定量CT研究显示文摘目的采用定量CT(QCT)和双能X线吸收测量(DXA)仪对健康老年妇女近段股骨骨密度(BMD)和骨结构进行研究,并对2种测量方法的结果进行比较。方法对66名65岁以上健康妇女左侧髋关节进行DXA测量,计算出股骨颈和粗隆区BMD;对其双侧近段股骨进行QCT测量,计算出股骨颈、粗隆区和整体股骨ROI的皮质骨、松质骨和总体骨的BMD和体积;并将QCT三维图像模拟DXA的平面投影计算出模拟DXA股骨颈BMD和模拟DXA股骨粗隆区BMD。对所获数据进行配对t检验或非参数秩和检验,并用Pearson法分析DXA和QCT相对应ROI的相关性。结果用QCT可以对股骨近段不同ROI(股骨颈、粗隆区和整体股骨区)及不同骨成分(皮质骨、松质骨和总体骨)的BMD及体积等参数进行精确的定量分析。除右侧股骨颈皮质骨BMD[(0.52±0.04)g/cm^3]、股骨粗隆区皮质骨BMD[(0.49±0.03)g/cm^3]、股骨粗隆区综合骨BMD[(0.22±0.04)g/cm^3]大于左侧相应参数[分别为[(0.51±0.04)、(0.48±0.03)、(0.21±0.04)g/cm^3],差异均有统计学意义(P值均〈0.05),但差别均〈3.3%;而模拟DXA股骨颈BMD、模拟DXA股骨粗隆区BMD、股骨颈皮质骨体积、股骨颈松质骨BMD、股骨颈松质骨体积、股骨颈综合骨BMD、股骨颈综合骨体积、股骨粗隆区皮质骨体积、股骨粗隆区松质骨BMD、股骨粗隆区松质骨体积、股骨粗隆区综合骨体积左侧参数分别为(0.52±0.10)g/cm^2、(0.78±0.13)g/cm^2、5.80cm^3、(0.06±0.03)g/cm^3、(5.19±1.40)cm^3、(0.25±0.04)g/cm^3、15.66cm^3、(21.74±3.43)cm^3、(0.08±0.03)g/cm^3、(34.27±6.09)cm^3、(76.12±11.11)cm^3,右侧分别为(0.52±0.10)g/cm^2、(0.78±0.13)g/cm^2、6.01cm^3、(0.06±0.02)g/cm^3、(5.17±1.27)cm^3、(0.25±0.04)g/cm^3、15.62cm^3、(22.12±3.60)cm^3、(0.09±0.03)g/cm^3、(34.17±5.94)cm^3、(76.53±10.71)cm^3,差异均无统计学意义(P值均〉0.05)。左右两侧近段股骨QcT各相对应参数之间的r值范围在0.656~0.955,均具有相关性(P〈0.05)。QcT模拟DXA股骨颈和粗隆区BMD与真正DXA测量的相应值之间r值分别为0.685和0.855,具有相关性(P〈0.05)。结论利用QCT技术可以对老年妇女近段股骨不同区域和不同成分的BMD和结构进行精确定量分析,QCT是骨质疏松研究中非常有用的测量技术。 | 程晓光 Li Jing 刘霞 王予生 李谨 屈辉 H Genant T Lang | 2009 | 中华放射学杂志2009，43，2： | 8 |
| 8 | The Research of Indoor Positioning Based on Visible Light Communication显示文摘The key techniques in indoor positioning based on visible light communication and the state of the art of this research were surveyed. First, the significance of indoor positioning based on visible light communication from two aspects of the limitations of current indoor positioning technology and the advantages of visible light communication was discussed; And then, the main four technology of indoor positioning based on visible light communication were summarized and the triangulation of RSS method and the principle of image positioning were introduced in detail; Next, the performance characteristics of various typical algorithms were compared and analyzed; In the end, several suggestions on future research of indoor positioning based on visible light communication were given. | WANG Chunyue WANG Lang CHI Xuefen LIU Shuangxing SHI Wenxiao DENG Jing | 2015 | China Communications2015，12，8： | 7 |
| 9 | Mushroom Poisoning Outbreaks — China, 2021显示文摘Summary What is already known about this topic?Mushroom poisoning is one of the most serious food safety issues in China.Most poisoning incidents resulted from eating mushrooms causing gastroenteritis and psycho-neurological disorder from which patients usually could fully recover.Most deaths resulted from species causing acute liver failure and rhabdomyolysis,and the remaining deaths were attributed to acute renal failure and hemolysis.What is added by this report?In 2021,the total number of investigations was 327 from 25 provincial-level administrative divisions,involving 923 patients and 20 deaths,and the overall mortality was 2.17%.Overall,74 poisonous mushrooms causing 6 different clinical syndromes were successfully identified,15 of which were newly recorded in China as poisonous mushrooms.What are the implications for public health practice?Considering the potential huge risks for collecting and eating wild mushrooms,we strongly advise not collecting and eating unfamiliar wild mushrooms.Promoting knowledge about poisonous mushrooms is essential and urgent to reduce mushroom poisonings.Precise species identification timely after mushroom poisoning is important for appropriate diagnosis and treatment.Many deaths were ascribed to delayed hospitalization. | Haijiao Li Hongshun Zhang Yizhe Zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma Yutao Zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun | 2022 | China CDC weekly2022，4，3： | 7 |
| 10 | A Foodborne Bongkrekic Acid Poisoning Incident--Heilongjiang Province,2020显示文摘What is already known on this topic?Poisoning incidents caused by bongkrekic acid(BA),one of the metabolites of Burkholderia gladioli pathovar cocovenenans(B.cocovenenans),have been reported in Indonesia,Mozambique,and China.The reported case fatality rates averaged 60%,32%,and 26.5%,respectively.In China,B.cocovenenans is often called Pseudomonas cocovenenans subsp.farinofermentans.What is added by this report?In October 2020,9 persons in Jidong County,Heilongjiang Province died after consuming a homemade fermented corn flour product—sour soup—with a case fatality rate of 100%.BA was detected in both food samples and biological samples with a content of 330 mg/kg and 3 mg/L,respectively.The doses of BA consumed by the cases were approximately 22-33 times the lethal dose in human.What are the implications for public health practice?The consumption of fermented corn flour products,deteriorated fresh tremella,or black fungus and metamorphic starch products may cause BA poisoning.Health education should be strengthened so that homemade-starch-fermented food should be avoided and foods that have been kept for a long time should not be consumed.Meanwhile,training and emergency capacity building for primary healthcare workers should be strengthened to provide timely diagnosis and response. | Yuan Yuan Rui Gao Qiang Liang Li Song Jun Huang Nan Lang Jing Zhou | 2020 | China CDC weekly2020，2，51： | 5 |
| 11 | Ischemia/hypoxia inhibits cardiomyocyte autophagy and promotes apoptosis via the Egr-1/Bim/Beclin-1 pathway显示文摘Background Myocardial injury caused by microvascular obstruction(MVO)is characterized by persistent ischemia/hypoxia(IH)of cardiomyocytes after microembolization.Autophagy and Egr-1 were closely associated with various cardiovascular diseases,including MVO.Bim and Beclin-1 are the important genes for autophagy and apoptosis.We aimed to explore whether the Egr-1/Bim/Beclin-1 pathway is involved in regulating autophagy and apoptosis in IH-exposed cardiomyocytes.Methods Neonatal rat cardiomyocytes exposed to the IH environment in vitro were transfected with lentivirus expressing Egr-1 or Egr-1 sh RNA,or further treated with 3-methyladenine(3-MA).The expressions of autophagy and apoptosis-associated genes were evaluated using RT-q PCR and Western blots assays.Autophagic vacuoles and autophagic flux were detected by transmission electron microscopy(TEM)and confocal microscope,respectively.Cell injury was assessed by lactate dehydrogenase(LDH)leakage,and apoptosis was determined by flow cytometry.Results IH exposure elevated Egr-1 and Bim expressions,and decreased Beclin-1 expression in rat cardiomyocytes.Egr-1 overexpression in IH-exposed cardiomyocytes significantly up-regulated the levels of Egr-1 and Bim,and down-regulated the level of Beclin-1.Egr-1 knockdown resulted in down-regulated expressions of Egr-1 and Bim,as well as up-regulated expression of Beclin-1.In addition,Egr-1 knockdown induced autophagy was suppressed by 3-MA treatments.TEM and autophagic flux experiments also confirmed that Egr-1 inhibited autophagy progression in IH-exposed cardiomyocytes.Egr-1 suppression protected cardiomyocytes from IH-induced injury,as evidenced by the positive correlations between Egr-1 expression and LDH leakage or apoptosis index in IH-exposed cardiomyocytes.Conclusions IH-induced cardiomyocyte autophagy and apoptosis are regulated by the Egr-1/Bim/Beclin-1 pathway,which is a potential target for treating cardiomyocyte injury caused by MVO in the IH environment. | Bo SU Xian-Tao WANG Yu-Han SUN Man-Yun LONG Jing ZHENG Wen-Hao WU Lang LI | 2020 | Journal of Geriatric Cardiology2020，17，5： | 4 |
| 12 | Mushroom Poisoning Outbreaks -China, 2022显示文摘Mushroom poisoning has become a serious food safety issue in China.With the support of the government,over the past decade,China has gradually established a mushroom poisoning prevention and treatment system involving experts in disease prevention and control,clinical diagnosis and treatment,fungal classification,and basic medicine(1–3). | Haijiao Li Yizhe Zhang Hongshun Zhang Jing Zhou Jiaqi Liang Yu Yin Qian He Shaofeng Jiang Yutao Zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun | 2023 | China CDC weekly2023，5，3： | 4 |
| 13 | Economic evaluation of cervical cancer screening strategies in urban China显示文摘Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban China.Methods:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period.Screening strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,respectively.Model outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and benefits.The cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation analysis.Univariate sensitivity analyses were performed to examine the stability of the results.Results:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 females.HPV DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining benefits.The CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per capita.The CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per capita.The incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant strategies.Conclusions:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China. | Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 14 | Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library显示文摘Currently,display-based methods are well established and widely used in antibody engineering for affinity maturation and structural stability improvement.We obtained a novel anti-human programmed death 1(PD-1)antibody using computer-aided design and a mammalian cell display technology platform.We used computer-aided modeling and distance geometry methods to predict and assign the key residues that contributed to the binding of human PD-L1 to PD-1.Then,we analyzed the sequence of nivolumab(an anti-human PD-1 antibody,referred to as MIL75 in the article)to determine the template for antibody design and library construction.We identified a series of potential substitutions on the obtained template and constructed a virtual epitope-targeted antibody library based on the physicochemical properties and each possible location of the assigned key residues.The virtual antibody libraries were displayed on the surface of mammalian cells as the antigen-binding fragments of full-length immunoglobulin G.Then,we used flow cytometry and sequencing approaches to sort and screen the candidates.Finally,we obtained a novel anti-human PD-1 antibody named FV78.FV78 competitively recognized the PD-1 epitopes that interacted with MIL75 and possessed an affinity comparable to MIL75.Our results implied that FV78 possessed equivalent bioactivity in vitro and in vivo compared with MIL75,which highlighted the probability and prospect of FV78 becoming a new potential antibody therapy. | Longlong Luo Shi Wang Xiaoling Lang Tingting Zhou Jing Geng Xinying Li Chunxia Qiao Jiannan Feng Beifen Shen Ming Lv Yan Li | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 15 | Ultra-high-Q resonances in terahertz all-silicon metasurfaces based on bound states in the continuum显示文摘High-Q metasurfaces have important applications in high-sensitivity sensing,low-threshold lasers,and nonlinear optics due to the strong local electromagnetic field enhancements.Although ultra-high-Q resonances of bound states in the continuum(BIC)metasurfaces have been rapidly developed in the optical regime,it is still a challenging task in the terahertz band for long years because of absorption loss of dielectric materials,design,and fabrication of nanostructures,and the need for high-signal-to-noise ratio and high-resolution spectral measurements.Here,a polarization-insensitive quasi-BIC resonance with a high-Q factor of 1049 in a terahertz all-silicon metasurface is experimentally achieved,exceeding the current highest record by 3 times of magnitude.And by using this ultra-high-Q metasurface,a terahertz intensity modulation with very low optical pump power is demonstrated.The proposed all-silicon metasurface can pave the way for the research and development of high-Q terahertz metasurfaces. | PENGFEI WANG FENGYAN HE JIANJUN LIU FANGZHOU SHU BIN FANG TINGTING LANG XUFENG JING ZHI HONG | 2022 | Photonics Research2022，10，12： | 4 |
| 16 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 17 | Carbohydrate antigen 19-9 as a novel prognostic biomarker in distal cholangiocarcinoma显示文摘BACKGROUND Distal cholangiocarcinoma(DCC)presents as one of the relatively rare malignant tumors in the digestive system and has a poor long-term prognosis.Curative resection is currently the most appropriate therapy for patients with DCC because of the lack of effective adjuvant therapies.Therefore,it is important to accurately predict the prognosis for formulating a reasonable treatment plan and avoiding unnecessary surgical trauma.AIM To minimize the interference of obstructive jaundice on carbohydrate antigen 19-9(CA19-9)level by adapting CA19-9 toγ-glutamyltransferase(GGT)as an indicator,to determine the strong associations between CA19-9/GGT and postoperative neoplasm recurrence and long-term outcome of DCC.METHODS We enrolled 186 patients who were diagnosed with DCC between January 2010 and December 2019 and performed radical excision with strict criteria as follows in our hospital.Receiver operating characteristic curves were drawn according to preoperative CA19-9/GGT and 1-year survival.Based on this,patients were divided into two groups(group 1,low-ratio,n=81;group 2,high-ratio,n=105).Afterwards,by the way of univariate and multivariate analysis,the risk factors influencing postoperative tumor recrudesce and long-term prognosis of patients with DCC were screened out.RESULTS Optimum cut-off value of CA19-9/GGT was 0.12.Patients in group 2 represented higher CA19-9 and lymphatic metastasis rate accompanied by lower GGT,when compared with group 1(P<0.05).The 1-,3-and 5-year overall survival rates of patients in groups 1 and 2 were 88.3%,59.2%and 48.1%,and 61.0%,13.6%and 13.6%,respectively(P=0.000).Multivariate analysis indicated that CA19-9/GGT,lymphatic metastasis and tumor differentiation were independent risk factors for tumor recurrence and long-term prognosis of DCC.CONCLUSION Elevation of CA19-9/GGT performed better as a biomarker of aggressive carcinoma and predictor of poor clinical outcomes by reducing the effect of obstruction of biliary tract on CA19-9 concentration in patients with DCC. | Tao Jiang Shao-Cheng Lyu Lin Zhou Jing Wang Han Li Qiang He Ren Lang | 2021 | World Journal of Gastrointestinal Surgery2021，13，9： | 3 |
| 18 | Effects of Allicin on Lipid Metabolism and Antioxidant Activity in Chickens显示文摘To investigate the effects of allicin on chickens' lipid and antioxidant performance, Hy-laying hens' diets were replenished with 0 mg · kg-1, 50 mg · kg-1, 100 mg · kg-1, and 150 mg · kg-1 allicin for 42 days, respectively. The alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglyceride(TG), total cholesterol(TCHO), high density lipoprotein(HDL), and low density lipoprotein(LDL) levels were measured in chicken serum. Superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) activity and malondialdehyde(MDA) levels were measured in chicken serum and liver tissue homogenate. The results showed that the supplement dose of allicin tested did not significantly change the activity of ALT or AST(P>0.05); TG and CHOL levels decreased with the increase of allicin additive doses, and the difference between treatment groups and CG was significant(P<0.05), and there was the best effect with 100 mg · kg-1; allicin significantly reduced the content of MDA, and increased SOD and GSH-Px activities compared with CG(P<0.05), and 100 mg · kg-1 of allicin resulted in the strongest SOD and GSH-Px activity. The antioxidant function test results of liver tissue homogenate were consistant with that of serum. Our findings indicated that allicin could enhance antioxidant capacity and reduce blood lipid level in chickens and 100 mg · kg-1 was the optimal amount of allicin additives. | Wang Gong-chen Han Lu-lu Wang Jing Lang Wan-nan Pan Chuan-yi Li Yan-fei | 2014 | Journal of Northeast Agricultural University(English Edition)2014，21，3： | 3 |
| 19 | Protective effects of carbenoxolone are associated with attenuation of oxidative stress in ischemic brain injury显示文摘Accumulating evidence has suggested that the gap junction plays an important role in the determination of cerebral ischemia, but the underlying mechanisms remain to be elucidated. In this study, we assessed the effect of a gap-junction blocker, carbenoxolone (CBX), on ischemia/reperfusion-induced brain injury and the possible mechanisms. By using the transient cerebral ischemia model induced by occlusion of the middle cerebral artery for 30 min followed by reperfusion for 24 h, we found that pre-administration of CBX (25 mg/kg, intracerebroventricular injection, 30 min before cerebral ischemic surgery) diminished the infarction size in rats. And this was associated with a decrease of reactive oxygen species generation and inhibition of the activation of astrocytes and microglia. In PC12 cells, H 2 O 2 treatment induced more coupling and apoptosis, while CBX partly inhibited the opening of gap junctions and improved the cell viability. These results suggest that cerebral ischemia enhances the opening of gap junctions. Blocking the gap junction with CBX may attenuate the brain injury after cerebral ischemia/reperfusion by partially contributing to amelioration of the oxidative stress and apoptosis. | Lang Zhang Yu-Min Li Yu-Hong Jing Shao-Yu Wang Yan-Feng Song Jie Yin | 2013 | Neuroscience Bulletin2013，29，3： | 3 |
| 20 | REDUCING THE PEAK-TO-AVERAGE POWER RATIO OF OFDM SYSTEM WITH LOW COMPLEXITY显示文摘This paper proposes a companding scheme, where small signals are enlarged and large signals are reduced, to reduce the Peak-to-Average Power Ratio(PAPR). Computer simulation results show that the proposed technique has two advantages at least when compared with the conventional methods such as partial transmit sequence, selective mapping and the previous companding. First, it gets better PAPR performances with a lower complexity. Second, the scheme achieves greater performances gain with hardly any damnification of OFDM signals in some degree. | Luo Renze Jing Longjiang Luo Lang Li Jie Zhu Weile | 2006 | Journal of Electronics(China)2006，23，1： | 2 |
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