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| 1 | Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide显示文摘Gestational trophoblastic neoplasia(GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma(CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor(PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases.The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics(FIGO)2000 criteria: four or more plateaued human chorionic gonadotropin(hCG)concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. However,the latter reason for treatment is no longer used by many centers. In addition,GTN is diagnosed with a pathological diagnosis of CCA or PSTT/ETT. For staging after a molar pregnancy, FIGO recommends pelvic-transvaginal Doppler ultrasound and chest X-ray. In cases of pulmonary metastases with more than 1cm, the screening should be complemented with chest computed tomography and brain magnetic resonance image. Single agent chemotherapy, usually Methotrexate(MTX) or Actinomycin-D(Act-D), can cure about 70% of patients with FIGO/World Health Organization(WHO) prognosis risk score ≤ 6(low risk), reserving multiple agent chemotherapy, such as EMA/CO(Etoposide,MTX, Act-D, Cyclophosphamide and Oncovin) for cases with FIGO/WHO prognosis risk score ≥ 7(high risk) that is often metastatic. Best overall cure rates for low and high risk disease is close to 100% and > 95%, respectively. The management of PSTT/ETT differs and cure rates tend to be a bit lower. The early diagnosis of this disease and the appropriate treatment avoid maternal death,allow the healing and maintenance of the reproductive potential of these women. | Antonio Braga Paulo Mora Andréia Cristina de Melo Angélica Nogueira-Rodrigues Joffre Amim-Junior Jorge Rezende-Filho Michael J Seckl | 2019 | World Journal of Clinical Oncology2019，10，2： | 15 |
| 2 | Brand Equity as a Signaling Phenomenon显示文摘 | Tülin Erdem Joffre Swait | 1998 | Journal of Consumer Psychology1998，，2： | 2 |
| 3 | Imaging of retroperitoneal ganglioneuroma显示文摘 | Philippe Otal Sana Mezghani Sala Hassissene Geert Maleux Daniel Colombier Hervé Rousseau Francis Joffre | 2001 | European Radiology2001，，6： | 2 |
| 4 | 放疗所致动脉损伤的诊断显示文摘目的 探讨放疗所致动脉损伤的血管造影表现及评价该病的血管造影的价值。 方法 分析 14例患者经血管造影证实为放疗后动脉损伤的影像学资料。 结果 14例动脉损伤的病变中, 10例为动脉狭窄、 3例为动脉闭塞、 1例为动脉瘤。病变位于髂动脉 5例,锁骨下动脉 4例,肾动脉 2例,肠系膜上动脉 3例。血管造影和超声检查显示所有患者的动脉损伤均位于放疗野内。 结论 血管造影可显示动脉损伤的范围,同时还为介入放射治疗提供入路。 | 刘鹏程 Rousseau Helve Joffre Francis Berregi Jean-Paul Bastide Cyril | 2001 | 罕少疾病杂志2001，8，2： | 2 |
| 5 | Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+T lymphocytes显示文摘 | Joffre O Gorsse N Romagnoli P | 2004 | Blood2004，103，11： | 1 |
| 6 | Immunohistochemical localization of L - type calcium channels in the developing first molar of the rat during odontoblast differentiation 显示文摘 | Senx D Joffre A Fosset M | 1994 | Archs oral Biol1994，19，2： | 1 |
| 7 | In vitro mineralization of a threedimensional collagen matrix by human dental pulp cells in the presence of chondroitin sulphate显示文摘 | Bouvier M Joffre A Magloire H | 1990 | Arch Oral Biol1990，35，4： | 1 |
| 8 | Changes in the rates of awareness,treatment and control of hypertension in Canada over the past two decades显示文摘 | Mc Alister FA Wilkins K Joffres M | 2011 | CMAJ2011，183，9： | 1 |
| 9 | Evaluation of the recovery of microbial functions during soil restoration using near infrared spectroscopy显示文摘 | Schimann H Joffre R Roggy J C | 2007 | Applied Soil Ecology2007，，37： | 1 |
| 10 | Renal artery stent placement: long-term results with the wallstent endoprosthesis显示文摘 | Hennequin LM Joffre FG Rousseau HP | 1994 | Radiology1994，191，3： | 1 |
| 11 | Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes显示文摘 | Joffre O Santolaria T Calise D | 2008 | Nat Med2008，14，1： | 1 |
| 12 | Mortality benefits from US population-wide reduction in sodium consumption:projections from 3 modeling approaches显示文摘 | Coxson PG Cook NR Joffres M | 2013 | Hypertension2013，61，3： | 1 |
| 13 | Awareness,treatment,and con-trol of hypertension in Canada显示文摘 | Joffres MR Ghadirian P Fodor JG | 1997 | Am J Hypertens1997，10，10： | 1 |
| 14 | Effects of TGF beta1 on dental pulp cells in cultured human tooth slices显示文摘 | Melin M Joffre Romeas A Farges JC | 2000 | J Dent Res2000，79，9： | 1 |
| 15 | Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers显示文摘 | Lefort S Joffre C Kieffer Y | 2014 | Autophagy2014，10，12： | 1 |
| 16 | Immunohistochemical localization of nerve growth factor (NGF) and NGF receptor ( NGF - R) in the developing first molar tooth of the rat 显示文摘 | Mitsiadis TA Dicou E Joffre A | 1992 | Differentiation1992，49，1： | 1 |
| 17 | Recommendations on screening for breast cancer in average-risk women aged 40-74 years显示文摘 | TONELLI M GORBER S C JOFFRES M | 2011 | CMAJ2011，183，17： | 1 |
| 18 | Brand Credibility, Brand Consideration, and Choice显示文摘 | Erdem Tulin Joffre Swait | 2004 | Journal of Consumer Research2004，31，1： | 1 |
| 19 | Reconstituted human gingival epithelium:Nousubmerged in vitro model显示文摘 | Delcourt-Huard A Corlu A Joffre A | 1997 | In Vitro Cell Dev Biol Anim1997，33，1： | 1 |
| 20 | Brand Credibility, Brand Consideration, and Choice显示文摘 | Tulin Erdem and Joffre Swait | 2004 | Journal of Marketing Research2004，，6： | 1 |
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