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| 1 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 2 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Coralline hydroxyapatite orbital implant(bio-eye): experience with 158 patients显示文摘 | Jordan D R Gilberg S Bawazeer A | 2004 | Ophthal Plast Reconstr Surg2004，20，1： | 1 |
| 5 | DArT markers:Diversity analyses and mapping in Sorghum bicolor显示文摘 | MACE E S XIA L JORDAN D R | 2008 | BMC Genomics2008，9，： | 1 |
| 6 | Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations显示文摘 | Jordan MA Toso RJ Thrower D et d | 1993 | Proc Natl Acad Sci USA1993，90，20： | 1 |
| 7 | Latent dirichlet allocation显示文摘 | Blei D Ng A Jordan M | 2003 | Journal of Machine Learning Research2003，3，1： | 1 |
| 8 | The Role Of Inertial Sensi- tivity In Motor Planning 显示文摘 | P N Sabes M I Jordan D M Wolpert | 2005 | Journal Of Neuroscience2005，，18： | 1 |
| 9 | The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells显示文摘 | Jordan CT Upchurch D Szilvassy S J | 2000 | Leukemia2000，14，10： | 1 |
| 10 | Sol Gel combustion synthesis and photoluminescent properties of YAG:Eu phosphors显示文摘 | CHEN D Y LIU Y JORDAN E | 2010 | Science of Advanced Materials2010，2，4： | 1 |
| 11 | Inhibition of self-incompatible pollen in Papaver rhoeas involves a complex series of cellular events显示文摘 | JORDAN N D RIDE J P RUDD J J | 2000 | Annals of Botany2000，85，： | 1 |
| 12 | The evolution of speed,size and shape in modern athletics显示文摘 | JORDAN D BEJAN A | 2009 | J Exp Biol2009，212，： | 1 |
| 13 | Latent Dir/chlet allocation显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | Journal of Machine Learning Research2003，3，： | 1 |
| 14 | Latent Dirichlet Allocation 显示文摘 | BLEI D M NG A Y JORDAN M I | 2003 | the Journal of Machine Learning Research2003，，3： | 1 |
| 15 | Learning strategies and navigation decisions of children using a hypermedia lesson显示文摘 | Gayle V D Shorter L Jordan K | 1999 | Journal of Educational Multimedia and Hypermedia1999，8，2： | 1 |
| 16 | The interleukin-3 receptor alpha chain is a unique marker for human acute myelogcnous leukemia stem Cells 显示文摘 | Jordan CT Upchurch D Szilvassy SJ | 2000 | Leakemia2000，14，10： | 1 |
| 17 | Chained cross-training of assembly line workers显示文摘 | Inman R R Jordan W C Blumenfeld D E | 2004 | International Journal of Production Research2004，42，10： | 1 |
| 18 | Active learning with statistical models 显示文摘 | D A Cohn Z Ghahramani M I Jordan | 1996 | Journal of Artificial Intelligence research1996，4，： | 1 |
| 19 | An animal model of he-mophagoeytic lymphohistiocytosis ( HLH) : CD8 + T cells and interfer-on gamma are essential for the disorder显示文摘 | Jordan MB Hildeman D Kappler J | 2004 | Blood2004，104，3： | 1 |
| 20 | Latent dirchlet alloca- tion 显示文摘 | Blei D M Ng A Jordan M | 2003 | Journal of Machine Learning Research2003，2，3： | 1 |
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