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| 1 | 62 kaBP以来湖光岩玛珥湖沉积物有机碳同位素记录及古气候环境意义显示文摘湖光岩玛珥湖HUG B孔岩心记录了62kaBP以来的古气候、古环境变化信息。全岩有机碳同位素组成(δ13CTOC)分析表明,62kaBP以来δ13CTOC值变化比较明显,其变化范围为-28.5‰~-15.5‰。结合孢粉和有机地球化学指标进行综合分析,湖光岩玛珥湖δ13CTOC变化曲线可划分为6个演化阶段:62~58和48~40.5kaBP两个时段的δ13CTOC值偏负,沉积物中有机质主要来源于热带—亚热带地区的陆生C3森林植被,反映了温暖潮湿的气候环境;58~48和40.5~17.2kaBP期间δ13CTOC值明显偏正,沉积物中有机质主要源自C4草本植物,反映了湖光岩地区有效降水量减少、干旱程度增加导致湖光岩玛珥湖湖面下降,大量C4草本植物生长在暴露的湖滨岸;17.2~4kaBP时段内δ13CTOC值尽管存在更加频繁的波动,但总体呈现逐渐偏负的趋势,反映了暖湿和冷干气候多次交替但总体上逐渐变暖、变湿的气候环境;4kaBP以来δ13CTOC值存在逐渐偏正的趋势,虽然不排除人类活动的影响,但很可能反映了干旱程度的再次增加。综合分析表明,有效降水量(降水量-蒸发量)是控制湖光岩玛珥湖地区C3/C4植物相对生物量变化的主导因素。湖光岩玛珥湖有机碳同位素的研究结果支持区域气候环境而不是大气CO2浓度变化是末期冰期以来热带低纬度地区C3/C4植被相对生物量变化的主要原因。 | 刘强 顾兆炎 刘嘉麒 游海涛 吕厚远 储国强 祁向雷 Jorg F W Negendank Jens Mingram Georg Schettler | 2005 | 海洋地质与第四纪地质2005，25，2： | 34 |
| 2 | 胰腺癌细胞株对氟尿嘧啶存在固有不敏感性显示文摘目的 研究胰腺癌细胞株是否对氟尿嘧啶 ( 5 - FU )具有固有或获得性不敏感。方法 用 SRB方法检测5 - FU对胰腺癌细胞株 As PC- 1、Capan- 1、Mia- Pa Ca- 2、Panc- 1和 T3 M4的毒性作用。结果 5 - FU对所有胰腺癌细胞株的 IC50 都很高 ,其中 Mia- Pa Ca- 2和 Panc- 1细胞株对 5 - FU最不敏感 ( IC50 =12 ,13 nmol/ L )。即使是在 5 - FU最敏感的 Capan- 1细胞株 ,其 IC50 仍相当高 ( 473 pm ol/ L)。这些细胞株对 5 - FU的 IC50 甚至高出其临床常用剂量给药时血浆药物浓度的 1~ 5 6倍。结论 大多数胰腺癌细胞株对 5 - FU固有不敏感 ,这些发现也许能作为临床上 5 - | 刘胜利 Helmut Friess Jorg Kleeff Markus W Bchler | 2002 | 中国药科大学学报2002，33，6： | 3 |
| 3 | Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity显示文摘 | Corbin Amie S Agarwal Anupriya Loriaux Marc Cortes Jorge Deininger Michael W Druker Brian J | 2011 | Journal of Clinical Investigation2011，，1： | 3 |
| 4 | Human Spermicidal Activity of Passiflora edulis Extract显示文摘Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; additionally, the cytotoxic effect of the extracts was evaluated by the tetrazolium bromide (MTT) reduction assay. Results The motility and viability were decreased immediately after treatment with a 21% dilution of the supernatant of the extract of P. edulis (P<0.001). No cytotoxic effect of the extracts studied was found on proliferation of MDBK and VERO cells. Conclusion These results may open the way for the use of P. edulis as a spermicidal product with less adverse effects. | Angela M.Alvarez-Gómez1 Wálter Cardona-Maya1 Jorge Forero Angela P.Cadavid | 2010 | Journal of Reproduction and Contraception2010，21，2： | 2 |
| 5 | Regal Crossing显示文摘 | Charles R Heidengren Jorge E Torrejon Don W Bergman | 2003 | Civil Engineering2003，，7： | 2 |
| 6 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 7 | Imaging electron wave functions of quantized energy levels in carbon nanotubes 显示文摘 | LIESBETH C V JEROEN W G JORG W J | 1999 | Science1999，283，： | 1 |
| 8 | Novel insight into inhibitor binding of highly symmetric HIV-1 protease显示文摘 | JORG W CHRISTIANE B GERMAN E | 2008 | Chem Bio Chem2008，9，6： | 1 |
| 9 | MR-guided interstitial laser-induced thermotherapy of hepatic metastasis combined with arterial blood flow reduction:technique and first clinical results in an open MR system显示文摘 | Frank K W Klaus R Jorg P R | 2001 | JMRI2001，13，： | 1 |
| 10 | Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy 显示文摘 | Christian W D Jorge E J Joseph S J | 1988 | Cardiovascular Research1988，22，： | 1 |
| 11 | Male domi- nance, paternity, and relatedness in the Jamaican frut-eat- ing bat ( Artibeus jamaicensis) 显示文摘 | JORGE o JESUS E M GERALD S W | 2003 | Molecular Ecology2003，12，： | 1 |
| 12 | Effect of lameness on the calving- to-conception interval in dairy cows 显示文摘 | Jorge H Jan KS Daniel W W | 2001 | Journal of the American Veterinary Medical Association2001，218，10： | 1 |
| 13 | Energy-management system for a hybrid electric vehicle, using ultracapacitors and neural networks显示文摘 | Jorge M Micah E O Juan W D | 2006 | IEEE Transactions on Industrial Electronics2006，，53： | 1 |
| 14 | Hydrolysates of native andmodified soy protein isolates: structural characteristics, solubility andfoaming properties显示文摘 | SARA E MOLINA O JORGE R W | 2002 | Food Research International2002，35，： | 1 |
| 15 | Using soil biomass as an indicator for the biological removal of effluent-derived organic carbon during soil infiltration显示文摘 | Tanja R W Jorg E Drewes J E | 2006 | Water Res2006，40，5： | 1 |
| 16 | The topology of complete minimal surfaces of finite total gaussian curvature 显示文摘 | JORGE L P M MEEKS III W H | 1983 | Topology1983，22，2： | 1 |
| 17 | Complications of operative and diagnostic laparoscopy: a retrospective study显示文摘 | Jorge RM Raymond W Gregory AL | 2001 | Obstet Gynecol2001，97，4： | 1 |
| 18 | Reactor Residence-time Distribution Effects on the Multistage Po- lymerization of Olefins III: Multi-layered Products: Impact Polypropylene显示文摘 | Jon A Debling Jorge J Zacca W Harmon Ray | 1997 | Chemical Engineering Science1997，52，12： | 1 |
| 19 | Knowledge transfer between and within alliance partners : pri- vate versus collective benefits of social capital 显示文摘 | Jorge Walter Christoph Lechner Franz W Kellermanns | 2007 | Journal of Business Research2007，60，7： | 1 |
| 20 | Biochemical and physiological mechanism mediated by allelochemicals显示文摘 | Tiffany L W Sang W P Jorge M V | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
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