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| 1 | Prognostic factors for recurrence of gastrointestinal bleeding due to Dieulafoy's lesion显示文摘AIM:To analyze the effectiveness of the endoscopic therapy and to identify prognostic factors for recurrent bleeding.METHODS:Retrospective study of patients with gastrointestinal bleeding secondary to Dieulafoy's lesion(DL) from 2005 to 2011.We analyzed the demographic characteristics of the patients,risk factors for gastrointestinal bleeding,endoscopic findings,characteristics of the endoscopic treatment,and the recurrence of bleeding.We included cases in which endoscopy described a lesion compatible with Dieulafoy.We excluded patients who had potentially bleeding lesions such as angiodysplasia in other areas or had undergone other gastrointestinal endoscopic procedures.RESULTS:Twenty-nine patients with DL were identified.Most of them were men with an average age of 71.5 years.Fifty-five percent of the patients received antiaggregatory or anticoagulant therapy.The most common location for DL was the stomach(51.7%).The main type of bleeding was oozing in 65.5% of cases.In 27.6% of cases,there was arterial(spurting) bleeding,and 6.9% of the patients presented with an adherent clot.A single endoscopic treatment was applied to nine patients(31%);eight of them with adrenaline and one with argon,while 69% of the patients received combined treatment.Six patients(20.7%) presented with recurrent bleeding at a median of 4 d after endoscopy(interquartile range = 97.75).Within these six patients,the new endoscopic treatment obtained a therapeutic success of 100%.The presence of arterial bleeding at endoscopy was associated with a higher recurrence rate for bleeding(50% vs 33.3% for other type of bleeding) [P = 0.024,odds ratio(OR) = 8.5,95% CI = 1.13-63.87].The use of combined endoscopic treatment prevented the recurrence of bleeding(10% vs 44.4% of single treatment)(P = 0.034,OR = 0.14,95% CI = 0.19-0.99).CONCLUSION:Endoscopic treatment of DL is safe and effective.Adrenaline monotherapy and arterial(spurting) bleeding are associated with a high rate of bleeding recurrence. | Yuliana Jamanca-Poma Antonio Velasco-Guardado Concepción Piero-Pérez Renzo Calderón-Begazo Josue Umaa-Mejía Fernando Geijo-Martínez Antonio Rodríguez-Pérez | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 2 | Optogenetics and its application in neural degeneration and regeneration显示文摘Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control of neurons. This drawback increases side effects due to non-specific targeting. Optogenetics is a technology that allows precise spatial and temporal control of cells. Therefore, this technique has high potential as a therapeutic strategy for neurological diseases. Even though the application of optogenetics in understanding brain functional organization and complex behaviour states have been elaborated, reviews of its therapeutic potential especially in neurodegeneration and regeneration are still limited. This short review presents representative work in optogenetics in disease models such as spinal cord injury, multiple sclerosis, epilepsy, Alzheimer's disease and Parkinson's disease. It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration. | Josue D.Ordaz Wei Wu Xiao-Ming Xu | 2017 | Neural Regeneration Research2017，12，8： | 10 |
| 3 | The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita显示文摘Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes. | Josue Barrera-Red on do Enrique Ibarra-Laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte | 2019 | Molecular Plant2019，12，4： | 9 |
| 4 | Imaging of the temporomandibular joint: An update显示文摘Imaging of the temporomandibular joint(TMJ) is continuously evolving with advancement of imaging technologies. Many different imaging modalities are currently used to evaluate the TMJ. Magnetic resonance imaging is commonly used for evaluation of the TMJ due to its superior contrast resolution and its ability to acquire dynamic imaging for demonstration of the functionality of the joint. Computed tomography and ultrasound imaging have specific indication in imaging of the TMJ. This article focuses on state of the art imaging of the temporomandibular joint. Relevant normal anatomy and biomechanics of movement of the TMJ are discussed for better understanding of many TMJ pathologies. Imaging of internal derangements is discussed in detail. Different arthropathies and commontumors are also discussed in this article. | Asim K Bag Santhosh Gaddikeri Aparna Singhal Simms Hardin Benson D Tran Josue A Medina Joel K Curé | 2014 | World Journal of Radiology2014，6，8： | 5 |
| 5 | Basic and clinical aspects of osteoporosis in inflammatory bowel disease显示文摘低骨头矿物质密度和在胃肠的疾病的骨折的增加的风险有多因素的致病。煽动性的肠疾病(IBD ) 与骨质疏松症和 osteopenia 的增加的风险被联系了,流行病的研究与 IBD 在病人报导了低骨头质量的增加的流行。当然,遗传玩一个重要角色与象全身的发炎那样的另外的因素一起,营养不良,性腺机能减退,在 IBD 的糖皮质激素治疗和另外的生活方式因素。在分子的水平职业人员煽动性的 cytokines 在 IBD 贡献肠的有免疫力的反应被知道提高骨吸收。有基因,影响造骨细胞功能, LRP5 可以涉及骨胳的发展,是可能的。另外,维生素D受体(VDR ) 和一些它的多型性的鉴定导致了考虑在他们和一些自体免疫的疾病之间的可能的关系并且可以通过它的免疫的努力涉及致病调节效果在发炎期间。试着解释我们发现了那的病理生理学为在全身的发炎之间的集成正在增加证据,骨头损失多半为激活的原子因素经由受体调停 kappa-B (等级) , RANK-ligand,和 osteoprotegerin,能影响 osteoclastogenesis 和 T 房间激活的蛋白质。尽管 glucocorticoids 能减少粘膜和全身的发炎,他们有否定地影响骨头质量的内在的质量。如果所有 IBD 病人应该被屏蔽,它仍然是争论的,特别在有先存在的病人为骨头疾病的风险因素。测量 BMD 的可得到的方法包括单个精力 X 光 absorptiometry, DXA,量的计算断层摄影术(QCT ) , X 光线照相术的 absorptiometry,和超声。DXA 是 establish 方法决定 BMD,并且习惯性地在臀部和腰椎被测量。有几种治疗选择,证明了他们的有效性,当象在其它之中的 calcitonin 和 teriparatide 那样的新突现的治疗尚待被评定时。 | Lorena Rodríguez-Bores JosuéBarahona-Garrido Jesús K Yamamoto-Furusho | 2007 | World Journal of Gastroenterology2007，13，46： | 5 |
| 6 | Role of laryngeal mask airway in laparoscopic cholecystectomy显示文摘Laparoscopic cholecystectomy is one of the most commonly performed surgical procedures and the laryngeal mask airway(LMA) is the most common supraglottic airway device used by the anesthesiologists to manage airway during general anesthesia. Use of LMA has some advantages when compared to endotracheal intubation, such as quick and ease of placement, a lesser requirement for neuromuscular blockade and a lower incidence of postoperative morbididy. However, the use of the LMA in laparoscopy is controversial, based on a concern about increased risk of regurgitation and pulmonary aspiration. The ability of these devices to provide optimal ventilation during laparoscopic procedures has been also questioned. The most important parameter to secure an adequate ventilation and oxygenation for the LMA under pneumoperitoneum condition is its seal pressure of airway. A good sealing pressure, not only state correct patient ventilation, but it reduces the potential risk of aspiration due to the better seal of airway. In addition, the LMAs incorporating a gastric access, permitting a safe anesthesia based on these commented points. We did a literature search to clarify if the use of LMA in preference to intubation provides inadequate ventilation or increase the risk of aspiration in patients undergoing laparoscopic cholecystectomy. We found evidence stating that LMA with drain channel achieves adequate ventilation for these procedures. Limited evidence was found to consider these devices completely safe against aspiration. However, we observed that the incidence of regurgitation and aspiration associated with the use of the LMA in laparoscopic surgery is very low. | José M Belena Ernesto Josué Ochoa Mónica Núnez Carlos Gilsanz Alfonso Vidal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 4 |
| 7 | Factors that influence outcome in non-invasive and invasive treatment in polycystic liver disease patients显示文摘AIM: To evaluate the factors that influence outcome of both non-invasive and invasive treatment of polycystic liver disease. METHODS: Analysis of clinical files of patients with complete follow-up from July 1986 to June 2006. RESULTS: Forty-one patients (male, 7; female, 34), 47.8 ± 11.9 years age, and 5.7 ± 6.7 years follow-up, were studied. Alkaline phosphatase (AP) elevation (15% of patients) was associated with the requirement of invasive treatment (IT, P = 0.005). IT rate was higher in symptomatic than non-symptomatic patients (65.4% vs 14.3%, P = 0.002), and in women taking hormonal replacement therapy (HRT) (P = 0.001). Cysts complications (CC) were more frequent (22%) in the symptomatic patients group (P = 0.023). Patients with body mass index (BMI) > 25 (59%) had a trend to complications after IT (P = 0.075). Abdominal pain was the most common symptom (56%) and indication for IT (78%). Nineteen patients (46%) required a first IT: 12 open fenestration (OF), 4 laparoscopic fenestration (LF) and 3 fenestration with hepatic resection (FHR). Three required a second IT, and one required a third procedure. Complications due to first IT were found in 32% (OF 16.7%, LF 25%, FHR 66.7%), and in thesecond IT in 66.7% (OF 100%). Follow-up mortality rate was 0. CONCLUSION: Presence of symptoms, elevated AP, and CC are associated with IT requirement. HRT is associated with presence of symptoms and IT requirement. Patients with BMI > 25 have a trend be susceptible to IT complications. The proportions of complications are higher in FHR and second IT groups. RS is more frequent after OF. | Josué Barahona-Garrido Jesús Camacho-Escobedo Eduardo Cerda-Contreras Jorge Hernández-Calleros Jesús K Yamamoto-Furusho Aldo Torre Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，20： | 4 |
| 8 | Epigenetic basis of Alzheimer disease显示文摘Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD.In this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD.The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD. | Angeles C Tecalco-Cruz JosuéO Ramírez-Jarquín María E Alvarez-Sánchez Jesus Zepeda-Cervantes | 2020 | World Journal of Biological Chemistry2020，11，2： | 4 |
| 9 | Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer显示文摘Estrogen receptor alpha(ERα) is detected in more than 70% of the cases of breast cancer. Nuclear activity of ERα, a transcriptional regulator, is linked to the development of mammary tumors, whereas the extranuclear activity of ERα is related to endocrine therapy resistance. ERα polyubiquitination is induced by the estradiol hormone, and also by selective estrogen receptor degraders, resulting in ERα degradation via the ubiquitin proteasome system. Moreover, polyubiquitination is related to the ERα transcription cycle, and some E3-ubiquitin ligases also function as coactivators for ERα. Several studies have demonstrated that ERα polyubiquitination is inhibited by multiple mechanisms that include posttranslational modifica-tions, intera-ctions with coregula-tors, a-nd forma-tion of specific protein complexes with ERα. These events are responsible for an increase in ERα protein levels and deregulation of its signaling in breast cancers. Thus, ERα polyubiquitination inhibition may be a key factor in the progression of breast cancer and resistance to endocrine therapy. | Angeles C Tecalco-Cruz Josué O Ramírez-Jarquín | 2018 | World Journal of Clinical Oncology2018，9，4： | 2 |
| 10 | Thermal behaviour analysis in a porcelainhoused ZnO surge arrester by computer simulations and thermography显示文摘In this article,an analysis of heat transfer in a porcelain-housed ZnO surge arrester is presented.Due to the fact that ZnO-based surge arresters are key components for protection and reliability of electrical systems,it is necessary to seek techniques to assure correct assessment.In porcelain-housed arresters,the air gap leads to an increased thermal resistance between the ambient and the varistor column.Consequently,a thermal analysis must consider convection and radiation heat transfer mechanisms,besides heat conduction.This study proposes the use of computational simulations in combination with thermography as a tool for a temperature-based estimation of the varistor state.For the analysis,temperature rise tests were performed in a 69-kV ceramic-housed arrester to measure material emissivity and produce data to fit the simulated response.Furthermore,the thermal response of the surge arresters subject to an impulsive energy input was evaluated.The simulations allow to relate varistors temperature and housing temperature with regard to a specified amount of dissipated power.The obtained results show that the used technique can be an effective method for arrester monitoring and may allow to define assessing criteria for a porcelain-housed arrester based on housing temperature measurements. | Arthur F.Andrade Edson G.Costa Josué M.B.Fernandes Helem M.M.Alves Cícero R.C.Amorim Filho | 2019 | High Voltage2019，4，3： | 2 |
| 11 | Noise characterization of an injec- tion-locked COEO with long-term stabilization显示文摘 | Charles W Josue D R | 2011 | Journal of Lightwave Technology2011，2919，： | 1 |
| 12 | A study on the modification of mesoporous mixed oxides supports for dry reforming of methane by Pt or Ru 显示文摘 | Davi C Carvalho Helvio Silvester A de Souza Josu M Filho | 2014 | Applied Catalysis A : General2014，47，： | 1 |
| 13 | The normal glenohumeral relationships显示文摘 | Joseph Pl Josue PG Stephanie LS | 1992 | J Bone Joint Surg(Am)1992，4，74： | 1 |
| 14 | Exploring the structure,a high-affinity and selective δ-opioid receptor nonpeptide agonist ligand显示文摘 | | 1999 | J Med Chem1999，42，： | 1 |
| 15 | A Method for Extracting the Fundamental Frequency Positive Sequence Voltage Vector Based on Simple Mathematical Transformations显示文摘 | Helber E P de Souza Fabrício Bradaschia Francisco A S Neves Marcelo C Cavalcanti Gustavo M S Azevedo Josué P de Arruda | | 0，，05： | 1 |
| 16 | A new APF strategy for path planning in environmentswith obstacles显示文摘 | Josu AgirrebeitiajRafael Aviles | 2005 | Mechanism and Machine Theory2005，，40： | 1 |
| 17 | The model based on the analytic hierarchy process for dynamic decision making in the energy industry case analysis of investment energy production in Finland 显示文摘 | Tomi Makipelto Josu Takala | 2009 | International Journal of Nuclear Governance Economy and Ecology2009，2，3： | 1 |
| 18 | Gaussian semiparametric estimation in ling memory in stochastic volatility and signal plus noise models 显示文摘 | Josu A | 2004 | Journal of Econometrics2004，119，1： | 1 |
| 19 | Drop53 activates the Hippo pathway to promote cell death in response to DNA damage显示文摘 | Colombani J Polesello C Josue F Tapon N | 2006 | Curr Biol2006，15，14： | 1 |
| 20 | Study of the paraffin deposit formation using the cold finger methodology for Brazilian crude oils显示文摘 | dos Santos Josue da S T Fernandes A C | 2004 | Journal of Petroleum Science and Engineering2004，45，12： | 1 |
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