|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of in-hospital medical complications on case fatality post-acute ischemic stroke: data from the China National Stroke Registry显示文摘 | WANG Peng-lian ZHAO Xing-quan YANG Zhong-hua WANG An-xin WANG Chun-xue LIU Li-ping WANGYi-long WANG Xin-gao JU Yi CHEN Sheng-yun CHEN Qi-dong QU Hui LU Jing-jing ZHANG Jing MA Rui-hua ZHANG Yu-mei WANG Yong-jun | 2012 | Chinese Medical Journal2012，，14： | 37 |
| 2 | State-of-the-art of 3D printing technology of cementitious material—An emerging technique for construction显示文摘In recent few years, significant improvement has been made in developing largescale 3 D printer to accommodate the need of industrial-scale 3 D printing. Cementitious materials that are compatible with 3 D printing promote rapid application of this innovative technique in the construction field with advantages of cost effective, high efficiency, design flexibility and environmental friendly. This paper firstly reviews existing 3 D printing techniques that are currently being used in commercial3 D printers. It then summarizes three latest development of largescale 3 D printing systems and identifies their relationships and limiting factors. Thereafter, critical factors that are used to evaluate the workability and printable performance of cementitious materials are specified. Easy-extrusive, easy-flowing, well-buildable, and proper setting time are significant for cementitious material to meet the critical requirements of a freeform construction process. Finally, main advantages, potential applications and the prospects of future research of 3 D printing in construction technology are suggested. The objective of this work is to review current design methodologies and operational constraints of largescale 3 D printing system and provide references for optimizing the performance of cementitious material and promote its responsible use with largescale 3 D printing technology. | MA GuoWei WANG Li JU Yang | 2018 | Science China(Technological Sciences)2018，61，4： | 28 |
| 3 | Numerical simulation for the coupling effect of local atmospheric circulations over the area of Beijing,Tianjin and Hebei Province显示文摘Using the model system MM5.V3 and multi-layer grid nesting technique, we have done a multi-scale numerical simulation over the area of Beijing, Tianjin and Hebei Province to analyze the temperature and wind field there and study its local circulations. The results show a coupling effect of Urban Heat Island Circulation (UHIC), Mountain Valley Breeze (MVB) and Sea Land Breeze (SLB) occurs in this area when the synoptic system is weak. The SLB can penetrate deep into the mainland for about 200 km when it is blooming. MVB can extend to south and cover almost the whole plain area in Beijing. Both MVB and SLB are diurnal periodical; meanwhile the phase of MVB drops behind that of SLB for about six hours. As a local circulation, the UHIC weakens the two circulations above, and it also has a diurnal period. As a result, the coupling effect of circulations reveals not only different features in spring-summer period and autumn-winter period in a year but also the difference between early morn- ing to noonday and afternoon to night in a day. We noted the diffusion of contamination over the area around Beijing, and found the steady presence of a transport routine of contamination over North-China throughout the year caused by the Coupling Effect mentioned above. This find is important for studying the environment pollution in this area. | LIU ShuHua LIU ZhenXin LI Ju WANG YinChun MA YanJun SHENG Li LIU HePing LIANG FuMing XIN GuoJun WANG JianHua | 2009 | Science China Earth Sciences2009，52，3： | 20 |
| 4 | Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction model显示文摘背景:间充质的干细胞(MSC ) 移植为心肌的修理提供一条新途径。然而,关于 MSC 移植的许多重要基本问题仍然保持未答复。有迫切需要从跳动的心识别 MSC 并且分析这条新途径的功效。试图本地化有磁力地标记的 MSC (MR-MSCs ) 并且监视补药的这研究与磁性的回声(先生) MR-MSCs 完成成像。方法:尖锐心肌的梗塞(AMI ) 被左前面的下降冠的动脉的汽球吸藏在猪创造。房间在心肌的梗塞以后经由 intracoronary 注入被交付。梗塞尺寸变化和心脏的功能与 3.0T 先生扫描仪被估计。结果然后被组织学、西方的污点分析证实。所有统计过程与 Systat (社会科学统计套装软体版本 12.01 ) 被执行。结果:26 猪的一个总数被划分成四个组(假冒操作组, n=6;有 PBS 移植的 AMI 组, n=6;标记的 MSC 组, n=7;未标记的 MSC 组, n=7 ) 。MSC, MR-MSCs (10 (7 ) 房间) 或在 MI 和连续心脏的先生成像研究在移植以后在 0, 4 和 8 个星期被执行以后, PBS 被 intracoronary 注射交付。先生成像证明 MI 尺寸在 MSC 移植以后减少了在标记并且未标记的组然而,增加在 MI 以后在 8 个星期在 AMI 组被看见。左室的喷射部分( LVEF )稍微在 AMI 组被增加(( 41.87+/-2.45 )%对( 39.04+/-2.80 )%, P>0.05 ),但是显著地在 MR-MSCs 组改善了(( 56.85+/-1.29 )%对( 40.67+/-2.00 )%, P<0.05 )并且未标记的组(( 55.38+/-1.07 )%对( 41.78+/-2.08 )%, P<0.05 )在 8 星期术后疗法。MR-MSCs 被普鲁士的蓝色和免疫进一步证实荧光灯的染色。西方的污点分析证明在 MSC 处理组和矩阵 metalloproteinase 的比率有象肌浆球蛋白重链和 troponin T 那样的 cardiomyocyte 标记的增加的表情 2 到 metalloproteinase 的织物禁止者, 1 与 AMI 组和假冒操作组相比在标记的组和未标记的组减少了。结论:移植 MR-MSCs 能改革新心肌层并且在 2 月的后续在一个 MI 模型阻止 remolding 并且代表一个比较喜欢的方法更好在未来理解干细胞治疗的机制临床的研究。 | QI Chun-mei MA Gen-shan LIU Nai-feng SHEN Cheng-xing CHEN Zhong LIU Xiao-jun HU Yao-peng ZHANG Xiao-li TENG Gao-jun JU Sheng-hong MA Ming TANG Yao-liang | 2008 | Chinese Medical Journal2008，，6： | 19 |
| 5 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 6 | ENHANCED OIL RECOVERY BY FLOODING WITH HYDROPHILIC NANOPARTICLES显示文摘In this paper, the mechanism of enhanced oil recovery using lipophobic and hydrophilic polysilicon (LHP) nanoparticles ranging in size from 10 to 500 nm for changing the wettability of porous media was analysed theoretically. A one-dimensional two-phase mathematical model considering the migration and adsorption of LHP and wettability change in reservoir rock was proposed, and a simulator was developed to quantitatively predict the changes in relative and ef- fective permeability of the oil and water phases and the oil recovery in sandstone after water driving. Numerical simula- tions were conducted to study the distribution of the particle concentration, the reduction in porosity and absolute per- meability, the LHP volume retention on pore walls and in pore throats along a dimensionless distance, and oil production performance. In conclusion, oil recovery can obviously be improved by flooding with hydrophilic nanometer powders though permeability declines for the retention of nanoparticles in porous media. It is suggested that an LHP concentration ranging from 0.02 to 0.03 is preferable to enhance oil recovery. | Binshan Ju Tailiang Fan Mingxue Ma | 2006 | China Particuology2006，4，1： | 16 |
| 7 | Single-phase-to-ground Fault Detection with Distributed Parameters Analysis in Non-direct Grounded Systems显示文摘The fast and accurate detection of the single-phaseto-ground fault is of great significance for the reliability and safety of the power supply.In this paper,novel algorithms for distribution network protection were proposed with distributed parameters analysis in non-direct grounded systems.At first,novel generating mechanisms of zero-sequence voltage and residual current were proposed.Then the compositions of residue parameters,including residual current and residual admittances,were decomposed in detail.After that,an improved algorithm for a fault resistance calculation of a single phase-to-earth fault was also proposed,and the algorithm is much more convenient as it only needs to measure the variation of the zero-sequence voltage and does not need the prerequisites of the faulty feeder selection.Furthermore,the fault feeder can also be selected by an improved calculation algorithm of zero-sequence admittance of the faulty feeder,which cannot be affected by the asymmetry of the network.Theoretical analysis and the MATALB/Simulink simulation results demonstrate the effectiveness of the proposed algorithms. | Baowen Liu Hongzhong Ma Honghua Xu Ping Ju | 2019 | CSEE Journal of Power and Energy Systems2019，5，1： | 16 |
| 8 | MicroRNAs in tomato plants显示文摘MicroRNAs (miRNAs) are a specialized class of small silencing RNAs that regulate gene expression in eukaryotes.In plants,miRNAs negatively regulate target mRNAs containing a highly complementary sequence by either mRNA cleavage or translational repression.As a model plant to study fleshy fruit ripening,miRNA studies in tomato have made great progress recently.MiRNAs were predicted to be involved in nearly all biological processes in tomato,particularly development,differentiation,and biotic and abiotic stress responses.Surprisingly,several miRNAs were verified to be involved in tomato fruit ripening and senescence.Recent studies suggest that miRNAs are related to host-virus interactions,which raises the possibility that miRNAs can be used as diagnostic markers for response to virus infection in tomato plants.In this review,we summarize our current knowledge systematically and advance future directions for miRNA research in tomato. | ZUO JinHua WANG YunXiang LIU HaiPing MA YuanZheng JU Zheng ZHAI BaiQiang FU DaQi ZHU Yi LUO YunBo ZHU BenZhong | 2011 | Science China(Life Sciences)2011，54，7： | 13 |
| 9 | Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales显示文摘The Serling Co region is located at the transitional zone of the interaction between the Indian monsoon and the westerlies over the Tibetan Plateau. The Serling Co lake covers a water area of2,389 km2(June 2017) in a 45,530 km2drainage basin. Under the dramatic hydro-meteorological changes on the Tibetan Plateau in recent decades, and complex hydrological compositions of rivers and lakes in the basin, the lake area expanded by 43%, from1,667 km2in 1976, to 2,389 km2in 2017 (1)In 2014 it surpassed Nam Co as the largest lake on the Tibetan Plateau [2], and exerts significant effect on regional environmental conditions. | Liping Zhu Junbo Wang Jianting Ju Ning Ma Yinsheng Zhang Chong Liu Boping Han Linshan Liu Mingda Wang Qingfeng Ma | 2019 | Science Bulletin2019，64，7： | 13 |
| 10 | High-security-level multi-dimensional optical storage medium:nanostructured glass embedded with LiGa_(5)O_(8):Mn^(2+) with photostimulated luminescence显示文摘The launch of the big data era puts forward challenges for information preservation technology,both in storage capacity and security.Herein,a brand new optical storage medium,transparent glass ceramic(TGC)embedded with photostimulated LiGa5O8:Mn2+nanocrystals,capable of achieving bit-by-bit optical data write-in and read-out in a photon trapping/detrapping mode,is developed.The highly ordered nanostructure enables light–matter interaction with high encoding/decoding resolution and low bit error rate.Importantly,going beyond traditional 2D optical storage,the high transparency of the studied bulk medium makes 3D volumetric optical data storage(ODS)possible,which brings about the merits of expanded storage capacity and improved information security.Demonstration application confirmed the erasable-rewritable 3D storage of binary data and display items in TGC with intensity/wavelength multiplexing.The present work highlights a great leap in photostimulated material for ODS application and hopefully stimulates the development of new multi-dimensional ODS media. | Shisheng Lin Hang Lin Chonggeng Ma Yao Cheng Sizhe Ye Fulin Lin Renfu Li Ju Xu Yuansheng Wang | 2020 | Light(Science & Applications)2020，9，1： | 12 |
| 11 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
| 12 | Hierarchical design of FeCo-based microchains for enhanced microwave absorption in C band显示文摘Microwave absorbing materials(MAMs)has been intensively investigated in order to meet the requirement of electromagnetic radiation control,especially in S and C band.In this work,FeCo-based magnetic MAMs are hydrothermally synthesized via a magnetic-field-induced process.The composition and morphology of the MAMs are capable of being adjusted simultaneously by the atomic ratio of Fe2+to Co2+in the precursor.The hierarchical magnetic microchain,which has a core–shell structure of twodimensional FexCo1−xOOH nanosheets anchored vertically on the surface of a one-dimensional(1D)Co microchain,shows significantly enhanced microwave absorption in C band,resulting in a reflection loss(RL)of lower than−20 dB at frequencies ranging from 4.4 to 8.0 GHz under a suitable matching thickness.The magnetic coupling of Co microcrystals and the double-loss mechanisms out of the core-shell structure are considered to promote the microwave attenuation capability.The hierarchical design of 1D magnetic MAMs provides a feasible strategy to solve the electromagnetic pollution in C band. | Yixuan Han Mukun He Jinwen Hu Panbo Liu Zhongwu Liu Zhonglei Ma Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，1： | 12 |
| 13 | Haze insights and mitigation in China: An overview显示文摘The present article provides an overview of the chemical and physical features of haze in China, focusing on the relationship between haze and atmospheric fine particles, and the formation mechanism of haze. It also summarizes several of control technologies and strategies to mitigate the occurrence of haze. The development of instruments and the analysis of measurements of ambient particles and precursor concentrations have provided important information about haze formation. Indeed, the use of new instruments has greatly facilitated current haze research in China. Examples of insightful results include the relationship between fine particles and haze, the chemical compositions and sources of particles, the impacts of the aging process on haze formation, and the application of technologies that control the formation of haze. Based on these results, two relevant issues need to be addressed: understanding the relationship between haze and fine particles and understanding how to control PM2.5. | Xuliang Zhuang Yuesi Wang Hong He Jianguo Liu Xinming Wang Tingyu Zhu Maofa Ge Ju Zhou Guiqian Tang Jinzhu Ma | 2014 | Journal of Environmental Sciences2014，26，1： | 12 |
| 14 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 15 | Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals显示文摘线粒体为精力新陈代谢和反应的氧种类(ROS ) 的生产是必要的。在未经触动的房间,呼吸线粒体展览自发的 “ superoxide flashes”,对短暂 mitochondrial 渗透转变(tMPT ) 结果的 quantal 生产 ROS 事件。这里,我们在表示 superoxide 生物传感器 mt-cpYFP 的生活老鼠在 mitochondrial superoxide 闪光和 tMPT 活动的 vivo 成像执行第一,并且表明他们联合到整个身体的葡萄糖新陈代谢。柔韧的 tMPT/superoxide 闪光活动发生在骨胳的肌肉和 anesthetized 的臀部的神经转基因的老鼠。在骨胳的肌肉,成像 tMPT/superoxide 闪光揭示了线粒体的迷宫的三维的网络同时地操作。tMPT/superoxide 闪光活动响应全身的葡萄糖挑战或胰岛素刺激澎湃,以一种显然调制频率的方式并且也在 tMPT 的 gating 模式包含移动。因此,在 tMPT 依赖的 mitochondrial ROS 的 vivo 成像,信号和 metabolism-tMPT-superoxide 的发现闪光联合标记为 mitochondrial 功能并且 ROS 处于健康和疾病发信号的学习的重要工艺、概念的进展。 | Huaqiang Fang Min Chen Yi Ding Wei Shang Jiejia Xu Xing Zhang Wanrui Zhang Kaitao Li Yao Xiao Feng Gao Shujiang Shang Jing-Chao Li Xiao-Li Tian Shi-Qiang Wang Jingsong Zhou Noah Weisleder Jianjie Ma Kunfu Ouyang Ju Chen Xianhua Wang Ming Zheng Wang Wang Xiuqin Zhang Heping Cheng | 2011 | Cell Research2011，21，9： | 11 |
| 16 | Androgen and prostatic stroma显示文摘Aim:To investigate the effect of androgen on the proliferation,differentiation and regression of canine prostatic stromal cells in vivo and human stromal cells in vitro.Methods:Twenty-two dogs,including 15 normal prostate doge and 7 prostatic hyperplasia dogs,had their serum concentration of testosterone and estrodiol determined by radioimmunoassay before and after castration.The expression of androgen receptor(AR)and estrogen receptor(ER)in the prostate were analysed by immunohistochemistry and semi-quantitative RT-PCR before and after castration.Light microscopy,transmission electron microscopy and TUNEL assay were carried out successively before and after castration to evaluate the prostatic histomorphology.In vitro serum-free cell cultures from human prostatic stroma were established and exposed to dihydrotestosterone(DHT).The proliferation of the cell culture was detected by MTT assay.The expression of TGFβ bFGF,AR,and smooth muscle cell(SMC) specific proteins (myosin and/or smoothelin)were detected using immunohistochemistry and RT-PCR.The differentiation from fibroblasts to smooth muscle cells was deduced by measuring the expression of SMC specific proteins.Results:Before castration,the serum concentrations of testosterone and estrodiol were not statistically different between normal and hyperplasia groups.Following castration,the serum concentration of testerone decreased rapidly in 2 days,and the concentration of estrodiol had no significant change compared with the pre-castration data.In the prostate,AR was presented in both the epithelial and stromal cells and the AR mRNA level was higher in hyperplasia than in normal prostate tissues(P<0.05).While ER predominantly existed in the prostate stromal cells and the ER mRNA had no difference between the hyperplasia and the normal group.Within the early phase of castration( | Yuan-Jie NIU, Teng-Xiang MA, Ju ZHANG, Yong XU, Rui-Fa HAN, Guang SUNDepartment of Prostatic Disease, Tianjin Institute of Urologial Surgery, Tianjin Medical University,Tianjin 300211, China | 2003 | Asian Journal of Andrology2003，5，1： | 11 |
| 17 | Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response显示文摘Hypoxic-ischemic brain damage(HIBD)is a common cause of infant death.The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells(PD-MSCs)in HIBD treatment.Seven-day-old rat pups were randomly divided into HIBD,PD-MSC,fibroblast,and control groups.Forty-eight hours after HIBD induction,cells at a density of 5×104 cells/10µl were injected into the cerebral tissue in the PD-MSC and fibroblast groups.The TNF-α,interleukin-17(IL-17),interferon-γ(IFN-γ),and IL-10 levels were detected through quantitative real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA).Regulatory T cell(Tregs)populations were detected through flow cytometry,and forkhead box P3(Foxp3)was measured through western blot analysis.Behavioral tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other treatments.The expression levels of pro-inflammatory cytokines were substantially upregulated after HI injury.Compared with fibroblast treatment,PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum(all P<0.01).Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD group.Moreover,the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups(all P<0.01).Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression. | Hongfang Ding Hui Zhang Huifang Ding Dong Li Xinhao Yi Xiaoxu Ma Ruijuan Li Mei Huang Xiuli Ju | 2017 | Cellular & Molecular Immunology2017，14，8： | 10 |
| 18 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 19 | Antitumor effect of recombinant human endostatin combined with cisplatin on rats with transplanted Lewis lung cancer显示文摘Objective: To observe the antitumor effect and mechanism of recombinant human endostatin(Endostar) injection in tumor combined with intraperitoneal injection of cisplatin on subcutaneous transplanted Lewis lung cancer in rats. Methods: A total of 30 C57 rats were selected, and the monoplast suspension of Lewis lung cancer was injected into the left axilla to prepare the subcutaneous transplanted tumor models in the axilla of right upper limb. The models were randomly divided into Groups A, B, and C. Medication was conducted when the tumor grew to 400 mm3. Group A was the control group without any interventional treatment. Group B was injected with Endostar 5 mg.kg-1.d for 10 d. Group C was given the injection of Endostar 5 mg.kg-1.d combined with intraperitoneal injection of cisplatin 5 mg.kg-1.d for 10 d. All the rats in three groups were executed the day after the 10-d medication and the tumor was taken off for measurement of volume and mass changes and calculation of antitumor rate, after which the vascular endothelial growth factor(VEGF) concentration in rats' plasma was determined by ELISA. The tumor tissues were cut for the preparation of conventional biopsies. After hematoxylin-eosin staining, the pathologic histology was examined to observe the structures of tumor tissues, VEGF score and microvessel density(MVD) in each group. Results: The volume and mass of tumor in Groups B and C were significantly lower than Group A(P < 0.05) while the tumor volume and mass in Group C were significantly lower than Group B(P < 0.05). The antitumor rate in Group C was significantly higher than Group B(P < 0.05), but the tumor VEGF score, MVD and plasma VEGF level in Group C were significantly lower than Groups A and B(P < 0.05). In Group B, the tumor VEGF score, MVD and plasma VEGF level were significantly lower than Group A(P < 0.05). The microscopic image of Group C showed that its number of active tumor cells and the blood capillary around tumor was significantly smaller than that of Groups A and B, and meanwhile atrophy and liquefactive necrosis were seen in local tumor. Conclusions: Endostar injection combined with intraperitoneal injection of cisplatin is effective in reducing tumor VEGF score and MVD of transplanted tumor tissues in rats with Lewis lung cancer to obstruct the nutrient supply of tumor cells and kill tumor cells, so that the inhibition of tumor cell proliferation and metastasis can be achieved with a remarkable effect. | Zhan-Wu Yu Ying-Hua Ju Cheng-Liang Yang Han-Bing Yu Quan Luo Ye-Gang Ma Yong-Yu Liu | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 10 |
| 20 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员