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| 1 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 2 | Fabrication and characterization of rugate structures composed of SiO_2 and Nb_2O_5显示文摘Gradient index layers and rugate structures were fabricated on a Leybold Syrus pro deposition system by plasma-assisted coevaporation of the low index material silica and the high index material niobium pentoxide. To obtain information about the compositional profiles of the produced layers, cross sectional transmission electron microscopy was used in assistance to deposition rate data recorded by two independent crystal monitors during the film preparation. The depth dependent concentration profiles were transformed to refractive index gradients by means of effective medium approximation. Based on the refractive index gradients the corresponding samples` transmission and reflection spectra could be calculated by utilizing matrix formalism. The relevance of the established refractive index profiles could be verified by comparison of the calculated spectra with the measured ones. | R. Leitel O. Stenzel S. Wilbrandt 1 D. Gbler V. Janicki N. Kaiser | 2005 | 光学精密工程2005，13，4： | 2 |
| 3 | Wireless Integrated Network Sensors显示文摘 | G J Pittie W J Kaiser | 2000 | Communications of the ACM2000，43，5： | 2 |
| 4 | Digital receiver technology,architecture,and appl ication显示文摘 | | 1996 | IEEE MIT-S Digest1996，，： | 1 |
| 5 | The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPSI transcription factor 显示文摘 | Kaiser F J Moroy T Chang G T | 2003 | J Biol Chem2003，278，： | 1 |
| 6 | Multimodal imaging of human brain activity:rational,biophysical aspects and modes of integration显示文摘 | Blinowska K Muller-Putz G Kaiser V | 2009 | Comput Intell Neurosci2009，，81： | 1 |
| 7 | Feline calicivirus p32,p39and p30proteins localize to the endoplasmic reticulum to initiate replication complex formation显示文摘 | Bailey D Kaiser W J Hollinshead M Moffat K Chaudhry Y Wileman T Sosnovtsev S V Goodfellow I G | 2010 | J Gen Virol2010，91，3： | 1 |
| 8 | Mucin gene (MUC1) transfered dendritic cells as vaccine: results of a phase I/II clinical trial显示文摘 | Pecher G Haling A Kaiser L | 2002 | Cancer Immunol Immunother2002，51，1112： | 1 |
| 9 | Wireless integrated network sensors显示文摘 | Pottie G J Kaiser W J | 2000 | Communication of the ACM2000，43，5： | 1 |
| 10 | Competition for attachment of aquaculture candidate probiotic and pathogenic bacteria on fish intestinal mucus 显示文摘 | Vine N G Leukes W D Kaiser H | 2004 | Journal of fish diseases2004，27，6： | 1 |
| 11 | Genetic basis forpulse crop improvement:Collection,preservation and genetic variation in relation to needed traits显示文摘 | VAN DER MAESEN L J G KAISER W J MARX F A | 1988 | Current plant and biotechnology in agriculture1988，5，： | 1 |
| 12 | Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells显示文摘 | Kaiser V Rhodes J | 2000 | Infect Immun2000，68，1： | 1 |
| 13 | Expression of mammalian defensen genes显示文摘 | Kaiser V Diamond G | 2000 | Journal of Leukocyte Biology2000，68，： | 1 |
| 14 | Identification of cytosolic alde- hyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein显示文摘 | Schnier J B Kaur G Kaiser A | 1999 | FEBS Letters1999，454，12： | 1 |
| 15 | Production and ELISA application of bispecific monoclonal antibodies against flu- orescein isothiocyanate (FITC) and horseradish peroxidase (HRP) 显示文摘 | Karawajew L Behrsing O Kaiser G | 1988 | J Immunol Methods1988，111，1： | 1 |
| 16 | Wireless integrated network sensors显示文摘 | Pottle G J Kaiser W J | 2000 | Communications of the ACM2000，43，5： | 1 |
| 17 | Wireless Integrated Network Sensors显示文摘 | POTTIE G J KAISER W J | 2000 | Communications of the ACM2000，43，5： | 1 |
| 18 | The Case for Antitrust Law to Police the Patent Hold up Problem in Standard Setting 显示文摘 | CARY G S NELSON W M KAISER S J | 2011 | Antitrust Law Journal2011，77，3： | 1 |
| 19 | An endophyte of Ach- natherum inebrians, an intoxicating grass of northwest China 显示文摘 | Bruehl G W Kaiser W J Klein R E | 1994 | Mycologia1994，86，6： | 1 |
| 20 | Influenza virus neuraminidase inhibitors显示文摘 | Gubareva L V Kaiser L Hayden F G | 2000 | The Lancet 20002000，，： | 1 |
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