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| 1 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Mycotoxins in Food and Feed: Present Status and Future Concerns显示文摘 | Bhat R Rai RV and Karim AA | 2010 | Comprehensive Reviews in Food Science and Food Safety2010，9，1： | 1 |
| 4 | Effect of isolation on fragility curves of highway bridges based on simplified approach 显示文摘 | KARIM K R YAMAZAKI F | 2007 | Soil Dynamics and Earthquake Engineering2007，27，5： | 1 |
| 5 | Efficient hydrogen peroxide decomposition on bimetallic Pt-Pd surfaces 显示文摘 | Hasnat M A Rahrnan M Maria Borhanuddin S M Siddiqua Ayesha Bahadur N M Karim M R | 2010 | Catalysis Communications2010，12，4： | 1 |
| 6 | Tumor-expressed B7-H1 and B7-DC in relation to PD-1 + T-cell infiltration and survival of patients with cervical carcinoma 显示文摘 | Karim R Jordanova ES Piersma SJ | 2009 | Clin Cancer Res2009，15，20： | 1 |
| 7 | Mobile phone applications in academic library service: A students' feedback survey 显示文摘 | Karim N S A Dams S H Hussin R | 2006 | Cam- pus- Wide Information System2006，23，1： | 1 |
| 8 | A short review of the impact and management of weedy rice 显示文摘 | KARIM S M R ISMAIL B S AZMI M | 2006 | Plant Protection Quarterly2006，21，： | 1 |
| 9 | Spinodal dewetting of thin polymer films 显示文摘 | Xie R Karim A Douglas J F Han C C Weiss R A | 1998 | Physical Review Letters1998，81，： | 1 |
| 10 | Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterialsites显示文摘 | Karim R Hodis HN Detrano R | | 0，，07： | 1 |
| 11 | Elastic wave scattering by cracks and inclusions in plates:In:plane case显示文摘 | KARIM M R AWAL M A KUNDU T | 1992 | International Journal of Solids and Structures1992，29，19： | 1 |
| 12 | Fabrication of a non-ce- ment binder using slag, palm oil fuel ash and rice husk ash with so- dium hydroxide 显示文摘 | Karim M R Zain M F M Jamil M | 2013 | Construction and Building Materials2013，49，： | 1 |
| 13 | A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) study 22844显示文摘 | Karim AB Maat B Hatlevoll R | 1996 | Int J Radiat Oncol Biol Phys1996，36，3： | 1 |
| 14 | Electrospinning fabrication and characterization of poly (viny alcohol)/montmorillonite/silver hybrid microfibers for antibacterial applications 显示文摘 | Park J H Karim M R Kim I K | 2010 | Colloid polym Sci2010，1，： | 1 |
| 15 | Effects of sodium dodecyl sulphate and sonication treatment on physicochemical properties of starch显示文摘 | Chan H T Bhat R Karim A A | 2010 | Food Chemistry2010，120，： | 1 |
| 16 | Genetics of resistance of rice cultivar ARC10550 to Bangladesh brown pianthopper teletype显示文摘 | Gurdev S Khush A N M Rezaul Karim E R Angeles | 1985 | Journal of Genetics (-)1985，，2： | 1 |
| 17 | Four epitopes on tumor necrosis factor-alpha defined by murine anti-tumor necrosis factor-alpha monoclonal antibodies显示文摘 | Karim B Beliard R Huart JJ | 1994 | Immunol Lett1994，41，23： | 1 |
| 18 | The significance of the Wnt pathway in the pathology of human cancers 显示文摘 | Karim R Tse G Putti T | 2004 | Pathology2004，36，2： | 1 |
| 19 | A comparison of external and en- doscopic endonasal dacryocystorhinostomy for acquired nasolacrimal duct obstuction显示文摘 | Karim R Ghabfial R Lynch T | 2011 | Clin Ophthalmol2011，5，： | 1 |
| 20 | Marginality andproblem-solving effectiveness in broadcast search显示文摘 | JEPPESEN LB KARIM R LAKHANI | 2010 | Or-ganization Science2010，21，5： | 1 |
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