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| 1 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 2 | Defining the healthy ' core mierobiome' of oral microbial communities 显示文摘 | Zaura E Keijser B J Huse SM | 2009 | BMC Microbiol2009，9，： | 1 |
| 3 | Modern Approach to Flatness Measurement and Control in Cold Rolling 显示文摘 | Carlstedt A G Keijser O | 1991 | Iron and Steel Engineer1991，68，4： | 1 |
| 4 | Diathermy loop excision in the management of cervical intraepithelial neoplasis diagnosis and treatment in one procedure显示文摘 | Keijser KGG Kenevnans P Zanden PH et a1 | 1992 | Am J Obstet Gynecol1992，166，4： | 1 |
| 5 | On the Progression and Stability of Adolescent Identity Formation:A Five-Wave Longitudinal Study in Early-to-Middle and Middle-to-Late Adolescence显示文摘 | Meeus W Van De Schoot R Keijsers L | | 0，，05： | 1 |
| 6 | Diatbermy loop excision in the management of ervical intraepithelial neoplasis diagnosis and treatment in one procedure显示文摘 | Keijser KGG Kenevnans P Zanden PH | 1992 | Am J Obstet Gynecol1992，166，4： | 1 |
| 7 | Pyrosequencing analysis of the oral mieroflora of healthy adults 显示文摘 | Keijser BJ Zaura E Huse SM | 2008 | J Dent Res2008，87，11： | 1 |
| 8 | Linear dependence of peak, mean, and pressure - time integral values in plantar pressure images显示文摘 | Keijsers NL Stolwijk NM Pataky TC | 2010 | Gait Posture2010，31，1： | 1 |
| 9 | Oncologic and functional results after treatment of giant cell tumors of bone 显示文摘 | Boons HW Keijser LC Schreuder HW | 2002 | Arch Orthop Trauma Surg2002，122，1： | 1 |
| 10 | Diathermy loop xecision in the management of cervical inlraepithelial neoplasis diagnosis and trvatrnent inone procedure 显示文摘 | Keijser kenevnans P Zanden PH | 1992 | Am J Obeter Gynecoe1992，166，4： | 1 |
| 11 | Modern Approach to Flatness Measure- ment and Control in Cold Rolling显示文摘 | Anders G Keijser O | 1999 | Iron and Steel Engineer1999，68，1： | 1 |
| 12 | An experimental assessment of grain size effects in the uniaxial straining of thin AI sheet with a few grains across the thickness 显示文摘 | JANSSENPJ M KEIJSER T H GEERSMJ D | 2006 | Materials Science and Engineering: A2006，419，12： | 1 |
| 13 | Diathermy Xoop excision in the management of cervical intraepitheliai neoplasia : diagnosis and treatment in one procedure显示文摘 | Keijser KG Kenemans P van der Zanden PH | 1992 | Am J Obstet Gynecol1992，166，4： | 1 |
| 14 | Cognitive-behavioral therapy for panic disorder with agoraphobia in older people : a compari- son with younger patients显示文摘 | Hendriks GJ Kampman M Keijsers GP | 2014 | Depress Anxiety2014，31，8： | 1 |
| 15 | Modern Approach to Flatness Measurement and Control in Cold Rolling显示文摘 | Carlstedt AG Keijser O | 1991 | Iron and Steel Engineer1991，68，4： | 1 |
| 16 | Pyrosequencing analysis of the Oral Microflora of healthy adults 显示文摘 | KEIJSER B J ZAURA E HUSE S M | 2008 | J Dent Res2008，87，11： | 1 |
| 17 | Diathermy, loop excision in the managenmnt of cervical intmepithellal neoplasa : diagnosis and treatment in procedure 显示文摘 | Keijser KG Kenemans P Van der Zanden PH | 1992 | Am Obstet Gynecol1992，166，4： | 1 |
| 18 | Defining the healthy 'core microbiome' of oral microbial communities 显示文摘 | Zaura E Keijser BJF Huse SM | 2009 | BMC mi- crobiol2009，15，9： | 1 |
| 19 | Diatherimy loopexcision in the management of cervical intraepithelial neoplasia diagnosis and treatment in one procedure显示文摘 | Keijser KG kenemans P Zanden PH | 1992 | Am J Obstet Gynecol1992，166，4： | 1 |
| 20 | lmnmnophenotypic markers to differentiate between benign and malignant melanocytic lesions显示文摘 | Keijser S Missotten GS Bonfrer JM | 2006 | Ophthalmol2006，90，： | 1 |
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