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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Salvage chemotherapy with irinotecan,5-fluorouracil and leucovorin for taxane-and cisplatin-refractory,metastatic gastric cancer 显示文摘 | Kim ST Kang WK Kang JH | 2005 | Br J Cancer2005，92，10： | 1 |
| 3 | CCL22 to activate treg migration and suppress depigmentation in vitiligo 显示文摘 | Eby JM Kang HK Tully ST | 2015 | J Invest Dermatol2015，135，6： | 1 |
| 4 | The anti-inflammatory actions of LCY-2-CHO,a carbazole analogue,in vascular smooth muscle cells显示文摘 | Ho FM Kang HC Lee ST | 2007 | Biochem Pharmacol2007，74，2： | 1 |
| 5 | Morphological and functional MRI, MRS, perfusion and diffusion changes after radiosurgery of brain metastasis 显示文摘 | Kang TW Kim ST Byun HS | 2009 | Eur J Radiot2009，72，： | 1 |
| 6 | Matrix metalloproteinase-9 activity in the plasma of patients after surgical resection of endometriosis显示文摘 | Abdallah MA Kang S Nakajima ST | | 0，，06： | 1 |
| 7 | Levels of plasma-soluble triggering receptor expressed on myeloid cells- 1 (sTREM- 1) are correlated with disease activity in rheumatoid arthritis 显示文摘 | Choi ST Kang EJ Ha YJ | 2012 | J Rheumatol2012，39，5： | 1 |
| 8 | Proteomics analysis of rice lesion mimic mutant (splI) reveals tightly localized pro- benazole-induced protein (PBZ1) in cells undergoing pro- grammed cell death 显示文摘 | Kim ST Kim SG Kang YH | 2008 | Journal of Proteome Research2008，7，4： | 1 |
| 9 | Synthetic opti- mization of Li 02 via co-- precipitation 显示文摘 | Lee MH Kang YJ Myung ST | 2004 | ElectrochimActa2004，50，： | 1 |
| 10 | Acomparative study on the shortterm clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer显示文摘 | Kim HJ Lee IK Lee YS Kang WK Park JK Oh ST Kim JG Kim YH | 2009 | Surg Endosc2009，23，8： | 1 |
| 11 | Reconstruction of a columellar defect with a nasolabial island flap 显示文摘 | Kang IG Jung JH Kim ST | 2014 | Clin Exp Otorhinolaryn- gol2014，7，2： | 1 |
| 12 | Effect of pravastatin on nephroprotection in deoxycorticosterone acetate-salt hyperten- sive rats显示文摘 | Kang CS Chang NC Chang ST | 2009 | J Hypertens2009，27，11： | 1 |
| 13 | A comparative study on the short-term clinico-pathologic outcomes of laparoscopic surgery versus con-ventional open surgery for transverse colon cancer显示文摘 | Kim HJ Lee JK Oh ST Kim JG IK Lee YS Kang WK Park Kim YH | 2009 | Surg Endosc2009，23，8： | 1 |
| 14 | Proteomic analysis of reactive oxygen species(ROS)-related proteins in rice roots显示文摘 | KIM SG KIM ST KANG SY | 2008 | Plant Cell Rep2008，27，： | 1 |
| 15 | Erythropoletin reduces epi|eptogenic processes following status epilepticus显示文摘 | Chu K Jung KH Lee ST Kim JH Kang KM Kim HK | 2008 | Epilepsia2008，49，10： | 1 |
| 16 | Change in patterns of antimicrobiol susceptibility and class 1 integrons显示文摘 | Kang SG Lee DY Shin ST | 2005 | J Veterinary Sci2005，6，3： | 1 |
| 17 | Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells 显示文摘 | Jung ST Reddy ST Kang TH | 2010 | Proc Natl Acad Sci USA2010，107，： | 1 |
| 18 | Aptamer-conjugated and drug-loaded acoustic droplets for ultrasound theranosis显示文摘 | Wang CH Kang ST Lee YH | | 0，，06： | 1 |
| 19 | CCL22 to Activate Treg migration and suppress depigmentation in vitiligo 显示文摘 | Eby JM Kang HK Tully ST | 2015 | J Invest Dermatol2015，135，6： | 1 |
| 20 | MicroRNAs induced during ischemic preconditioning 显示文摘 | Lee ST Chu K Jung KH Yoon H J Jeon D Kang KM | 2010 | Stroke2010，41，8： | 1 |
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