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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Magnetron sputtering;a review of recent development and applications显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，： | 1 |
| 5 | 显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，： | 1 |
| 6 | A low-glycemic index diet combined with exercise reduces insulin resistance,postprandial hyperinsulinemia,and glucose-dependent insulinotropic polypeptide responses in obese,prediabetichumans显示文摘 | Solomon T P Haus J M Kelly K R | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 7 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 8 | Magnetron SputterDg:a Review of Recent Developments and Applications显示文摘 | Kelly P J Amell R D | | 0，，03： | 1 |
| 9 | Progesterone control of interleukin -8 production in endometrium and chorio - decidual cells underlines the role of the neutrophil in menstruation and parturition 显示文摘 | Kelly R W Illingworth P Baldie G | 1994 | Hum Repord1994，9，2： | 1 |
| 10 | Magnetron Sputtering:A Review ofRecent Developments and Applications显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，3： | 1 |
| 11 | The roles of gender,the menopause and hormone replacement on cardiovascular function显示文摘 | HAYWARD C S KELLY R P COLLONS P | 2000 | Cardiovasc Res2000，46，1： | 1 |
| 12 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 13 | Review and discussion of the compications of minimally invasive pectus excavatum repair显示文摘 | Nuss D Croitoru D P Kelly R E | 2002 | Eur J Pediatr Surg2002，12，4： | 1 |
| 14 | 显示文摘 | Leigh R Horsewood P | 2000 | J Allergy Clin Immunol2000，105，61： | 1 |
| 15 | Role of prior exposure on anaerobic degradation of naphthalene and phenanthrene in marine harbor sediments显示文摘 | Lnry A Hayes Kelly P Nevin Derek R Lovley | 1999 | Organic Geochemistry1999，30，： | 1 |
| 16 | Identification and potential use of a molecular marker for rust resistance in common bean显示文摘 | Miklas P N Stavely J R Kelly J D | 1993 | Theor Appl Gene1993，85，： | 1 |
| 17 | 显示文摘 | Arnell R D Kelly P J Musil J | 1999 | Surface and Coating Technology1999，112，： | 1 |
| 18 | Renew and discussion of the complications of minimally invasive pectus excavatum repair显示文摘 | Nuss D Croitoru D P Kelly R E | | 0，，04： | 1 |
| 19 | Recent advances in magnetron sputtering显示文摘 | AMELL R D KELLY P J | 1999 | Surface and Coatings Technology1999，112，1： | 1 |
| 20 | Matched-filter theory for high- velocity, accelerating targets显示文摘 | E J Kelly R P Wishner | 1965 | IEEE Military Electron- ics1965，9，1： | 1 |
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