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| 1 | Symmetric-key cryptosystem with DNA technology显示文摘DNA cryptography is a new field which has emerged with progress in the research of DNA computing. In our study, a symmetric-key cryptosystem was designed by applying a modern DNA biotechnology, microarray, into cryptographic technologies. This is referred to as DNA symmetric-key cryptosystem (DNASC). In DNASC, both encryption and decryption keys are formed by DNA probes, while its ciphertext is embedded in a specially designed DNA chip (microarray). The security of this system is mainly rooted in difficult biology processes and problems, rather than conventional computing technology, thus it is unaffected by changes from the attack of the coming quantum computer. The encryption process is a fabrication of a specially designed DNA chip and the decryption process is the DNA hybridization. In DNASC, billions of DNA probes are hybridized and identified at the same time, thus the decryption process is conducted in a massive, parallel way. The great potential in vast parallelism computation and the extraordinary information density of DNA are displayed in DNASC to some degree. | LU MingXin1,2*, LAI XueJia3*, XIAO GuoZhen4,2 & QIN Lei5 1 Department of Information Management, Nanjing University, Nanjing 210093, China 2 State Key Lab of Information Security, Institute of Software of Chinese Academy of Science, Beijing 100049, China 3 Department of Computer Science & Engineer, Shanghai Jiao Tong University, Shanghai 200030, China 4 State Key Lab of ISN, Xidian University, Xi’an 710071, China 5 Cancer Research Institute, Queen’s University, Kingston, Ontario, K7L3N6, Canada | 2007 | Science in China(Series F)2007，50，3： | 14 |
| 2 | In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha(HIF-1)Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA显示文摘A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the SWCNTs.When complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 activity.The ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell types.Moreover,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor HIF-1.As elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents. | Geoffrey Bartholomeusz Paul Cherukuri John Kingston Laurent Cognet Robert Lemos Jr Tonya KLeeuw Laura Gumbiner-Russo RBruce Weisman Garth Powis | 2009 | Nano Research2009，2，4： | 7 |
| 3 | Three global conditions for biodiversity conservation and sustainable use: an implementation framework显示文摘‘Nature and its vital contributions to people,which together embody biodiversity and ecosystem functions and services,are deteriorating worldwide’[1].The United Nations Convention on Biological Diversity(CBD)is intended to ensure conservation of biodiversity,its wise use,and sharing of benefits from use of genetic resources.Through it,the Strategic Plan(SP)for Biodiversity 2011-2020 was created to make progress toward a vision of humanity‘Living in Harmony with N ature’by 2050[2].W hen that vision is realized,biodiversity will be valued,conserved,restored,and wisely used,so it can maintain ecosystem services and sustain a healthy planet. | Harvey Locke Erie C.Ellis Oscar Venter Richard Schuster Keping Ma Xiaoli Shen Stephen Woodley Naomi Kingston Nina Bhola Bernardo B.N.Strassburg Axel Paulsch Brooke Williams James E.M.Watson | 2019 | National Science Review2019，6，6： | 6 |
| 4 | 基因修饰BMSCs抑制增生性瘢痕的实验研究显示文摘目的通过将转染TGF-β3c2s2基因的兔BMSCs移植于兔耳瘢痕模型,观察转基因BMSCs对创面愈合后增生性瘢痕形成的影响。方法成年健康日本大耳白兔20只,体重1.7~2.5kg,雌雄不拘。取第3代兔BMSCs,经Ad-TGF-β3c2s2在感染复数150下转染,培养孵育24h后,调整细胞浓度为1×105/mL备用。将纯化、浓缩的Ad-TGF-β3c2s2颗粒,DMEM/F12(不含FBS)稀释为1×108pfu/mL备用。于20只日本大耳白兔双侧兔耳分别制备两个2cm×2cm大小的腹侧全层皮肤、软骨缺损创面。将每只兔的4个创面随机分为空白对照组(A组)、Ad-TGF-β3c2s2组(B组)、BMSCs组(C组)和BMSCs/Ad-TGF-β3c2s2组(D组),并以自身正常皮肤作为正常对照(E组)。将备好的细胞及病毒液分别按创面分组进行局部移植。于术后21、45、90d行大体观察、瘢痕硬度和厚度测定、HE染色和免疫组织化学检测。结果大体观察:A、B、C组上皮化后创面均逐渐形成不同程度的瘢痕,伤后45d瘢痕增生程度达高峰,明显高出皮肤表面,持续至90d,D组在观察期内均无明显高出周围皮肤的瘢痕形成。术后45d和90d,A、B、C组瘢痕厚度和硬度明显高于D组,且差异均有统计学意义(P<0.01),而B组低于A、C组,差异有统计学意义(P<0.01);D组愈合后创面厚度和硬度与正常皮肤接近。HE染色观察:A、C组伤后45d可见浅层组织结构排列紊乱,胶原纤维粗大,呈交错网织状排列;B组和D组结构与正常皮肤接近,但较E组胶原排列致密,表皮较A、C组薄;90d各组结构与45d相似。BrdU免疫组织化学观察,伤后21、45d,C、D组均能见到散在分布、胞核染色阳性的棕色细胞,A、B、E组均为阴性。结论创面局部移植人TGF-β3c2s2基因修饰的BMSCs,具有抑制创面愈合后增生性瘢痕的作用。 | 邱林 金先庆 Paul A Kingston 罗小辑 丁幸坡 | 2008 | 中国修复重建外科杂志2008，22，2： | 4 |
| 5 | Enhancement of mechanical performance of epoxy/carbon fiber laminate composites using single-walled carbon nanotubes显示文摘 | Behnam Ashrafi Jingwen Guan Vahid Mirjalili Yunfa Zhang Li Chun Pascal Hubert Benoit Simard Christopher T. Kingston Orson Bourne Andrew Johnston | 2011 | Composites Science and Technology2011，，13： | 2 |
| 6 | TGF-β 3c2s2基因转染骨髓间充质干细胞对创面愈合中转化生长因子β表达的影响及意义显示文摘目的:外伤后病理性瘢痕的形成与创面的愈合过程有着密切的联系。创伤愈合时期引入细胞因子或生长因子及其他影响因素。调节创伤愈合机制,即可能改变细胞外基质结构。达到预防瘢痕形成的目的。实验拟观察TGF-β3c2s2基因转染的骨髓间充质干细胞在创面修复与重塑过程中对转化生长因子β1和转化生长因子β3表达的影响。方法:实验于2005-10/2007-03年在重庆医科大学附属儿童医院外科实验室、动物实验中心完成。①实验材料:四五周龄日本大耳白兔2只,体质量300~400g,雌雄不限;健康成年日本大耳白兔20只。体质量1.7-2.5kg。雌雄不限,均由重庆医科大学动物实验中心提供,实验过程中对动物处置符合动物伦理学标准。②实验方法:选取四五周龄日本大耳白兔分离培养骨髓闻充质干细胞。选取健康成年日本大耳白兔20只,每只兔耳腹侧制作2个皮肤、软骨全层缺损创面共80个。创面以自身对照为前提随机分为4组。每组20个创面:实验组:加入Ad—TGF-β3c2s2转染的骨髓间充质干细胞:空白对照组:加入消毒的DMEM/F12(不含胎牛血清):腺病毒组:加入Ad—TGF—β3c2s2腺病毒;骨髓间充质干细胞组:加入骨髓间充质干细胞。③实验评估:观察瘢痕形成情况。苏木精-伊红染色、免疫组织化学技术观察瘢痕组织的组织学形态和检测瘢痕组织中转化生长因子β1和转化生长因子β3表达和变化规律。结果:①实验组在整个过程中无明显高出周围皮肤的瘢痕形成。其他组上皮化后。创面均逐渐形成不同程度的瘢痕。伤后45d瘢痕增生程度达高峰。明显高出皮肤表面;持续至90d左右。②实验组和腺病毒组结构较接近正常皮肤,比正常皮肤胶原排列致密。略厚:空白对照组、骨髓间充质干细胞组伤后45d可见浅层组织结构排列紊乱。胶原纤维粗大呈交错网织状排列。③实验组伤后21,45,90d转化生长因子β1表达明显低于其他组和正常皮肤(P〈0.01)。其表达随时间逐渐下降,转化生长因子β3表达高于其他组和正常皮肤(P〈0.01)。各组转化生长因子β3的表达随时间逐渐下降。结论:TGF-β3c2s2基因转染的骨髓间充质干细胞移植于局部创面。对创面修复过程中转化生长因子β1和转化生长因子β3表达有显著影响。通过这种影响减轻创面修复后增生性瘢痕的形成。 | 邱林 金先庆 Paul A Kingston 罗小辑 丁幸坡 | 2008 | 中国组织工程研究与临床康复2008，12，21： | 2 |
| 7 | Challenges in transforming manufacturing organisations into product-service providers显示文摘 | Veronica Martinez Marko Bastl Jennifer Kingston Stephen Evans | 2010 | Journal of Manufacturing Technology Management2010，，4： | 2 |
| 8 | The chemistry of taxo 显示文摘 | Kingston D G O | 1992 | J Nat Prod1992，55，2： | 1 |
| 9 | Fluoroscopically guided synechiolysis for patients with Asherman's syndrome : menstrual and fertility outcomes 显示文摘 | Thomson AM Abbott JA Kingston' A | 2007 | Fertil Steril2007，87，2： | 1 |
| 10 | Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma 显示文摘 | Kingston JE Hungerford JL Madreperla SA | 1996 | Arch Ophthalmol1996，114，11： | 1 |
| 11 | Pulmonaryembolism: differences in presentation between older and youngerpatients 显示文摘 | Timmons S Kingston M Hussain M | 2003 | Age Ageing2003，32，： | 1 |
| 12 | HOT AIR lifts noncoding KNAs to new levels显示文摘 | Woo CJ Kingston RE | 2007 | Cell2007，129，12： | 1 |
| 13 | Accuracy of anterior intra-articular injection of the glenohumeral joint 显示文摘 | SETHI P M KINGSTON S ELATTRACHE N | 2005 | Arthroscopy: The Journal of Arthroscopic Related Surgery2005，21，1： | 1 |
| 14 | Measurement of residual stress in thick section composite laminates using the deep-hole method显示文摘 | M.G. Bateman O.H. Miller T.J. Palmer C.E.P. Breen E.J. Kingston D.J. Smith M.J. Pavier | 2005 | International Journal of Mechanical Sciences2005，，11： | 1 |
| 15 | Schr-dinger factorization method for a one-dimensional harmonic osciator,raising and lowering operators显示文摘 | Kingston A E Safronva M S | 1986 | Phys Rew D1986，33，： | 1 |
| 16 | The structure of glucose-fructose oxidoreductase from Zymomonas mobilis:an osmoprotective periplasmic enzyme containing non-dissociable NADP显示文摘 | KINGSTON R L SCOPES R K BAKER E N | 1996 | Structure1996，4，12： | 1 |
| 17 | UK National Guidelines on the Management of Syphilis 2008 显示文摘 | Kingston M French P Goh B | 2008 | Int J STD AIDS2008，19，11： | 1 |
| 18 | Carcinoma of the ampulla of vater显示文摘 | Knox RA Kingston RD | 1986 | Br J Surg1986，73，： | 1 |
| 19 | Lifeth reatening obstetric haemorrhage in second trimester from a p lacenta percreta with raised alphafetop rotein levels显示文摘 | Kapoor DS T incello DG Kingston RE | 2003 | J Obstet Gynecol2003，23，25： | 1 |
| 20 | Release characteristics of selected carbon nanotube polymer composites 显示文摘 | KINGSTON C ZEPP R ANDRADY A | 2014 | Carbon2014，68，： | 1 |
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