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| 1 | Definitions and progress of ecosystem health and ecological security显示文摘Along with industrial development, adverse impacts on the natural environment become more serious, and the states of ecosystem health and ecological security have also deteriorated. As the basic needs for human survival, ecosystem health and ecological security possess very important meanings. Therefore, ecosystem health and ecological security have become research hot topics in recent decades. This paper reviewed the developments of definitions and applications of ecosystem health and ecological security, and found that the research on ecosystem health had achieved a lot. However, the research on ecological security was still relatively undeveloped. Moreover, there are also some confusion between the concepts of ecosystem health and ecological security. We consider that ecosystem health indicates the status of the ecosystem in normal conditions, whereas, ecological security indicates the capabilities of an ecosystem to react to external accidents or extremely adverse effects. An ecosystem which is healthy does not mean that it is secure. However, the ecological security requires an ecosystem to possess the capacity for integrity against any risk, and ecosystem health is the precondition to ecological security. | Weng Changhua Zhang Luoping David Klumpp | 2006 | Ecological Economy2006，2，3： | 4 |
| 2 | Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia - induced cell death显示文摘Epidermal growth factor receptor(EGFR)signaling has become an importanttarget for drug development becauseEGFR signaling enhances tumor cell proliferation,migration,and invasion and inhibits apoptosis.However,theresults of clinical trials using EGFR inhibitors in patients with solid tumors have been disappointing.Here,wereport a protective effect of the EGFR inhibitors AG1478 and PD153035 against cell death induced by acute hy-poxia,which contrasts with their proapoptotic effects under normoxia.Under hypoxic conditions,both agents re- | Steinbach JP Klumpp A Wolburg H Weller M | 2004 | 中国神经肿瘤杂志2004，2，1： | 4 |
| 3 | Emerging pollutants in the environment:A challenge for water resource management显示文摘A significant number of emerging pollutants(EPs)resulting from point and diffuse pollution is present in the aquatic environment.These are chemicals that are not commonly monitored but have the potential to enter the environment and cause adverse ecological and human health effects.According to the NORMAN network,at least 700 substances categorized into 20 classes,have been identified in the European aquatic environment.In light of their potential impact action is urgently required.In this study,we present a concept that shows the current state of art and challenges for monitoring programs,fate and risk assessment tools and requirements for policies with respect to emerging pollutants as a base for sustainable water resource management.Currently,methods for sampling and analysis are not harmonized,being typically focused on certain EP classes.For a number of known highly hazardous EPs detection limits are too high to allow proper risk assessment.For other EPs such as microplastics method development is in its infancy.Advanced ultra-sensitive instrumental techniques should be used for quantitative determination of prioritized EPs in water,suspended matter,soil and biota.Data on EPs'and their metabolites'properties that determine their fate in the environment are often not available.National surveys on water quality often use different parameters for water quality assessment and often do not include EPs.A harmonized monitoring of surface and groundwater is not yet achieved and urgently required.Specific component integrated into models assessing the fate of EPs in a multi compartment environmental approach are missing and must be developed.The main goal of risk assessment is the overall protection of ecological communities in the aquatic environment and human health.New methods for assessing the cumulative risks from combined exposures to several stressors,including mixtures of EPs in a multi-scale approach are required.A combination of regulations and management measures with respect to use/emissions of EPs into the environment,as well as to their occurrence in the environment are fundamental to reach an efficient water resource management. | Violette Geissen Hans Mol Erwin Klumpp Günter Umlauf Marti Nadal Martine van der Ploeg Sjoerd E.A.T.M.van de Zee Coen J.Ritsema | 2015 | International Soil and Water Conservation Research2015，3，1： | 3 |
| 4 | Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics 显示文摘 | Klumpp C Kostarelos M Prato M | 2000 | Biochem Biophys Aeta2000，1758，3： | 1 |
| 5 | Sorption of 2,4-dichlorophenol on modified hydrotalcites 显示文摘 | Klumpp E Contreras 0 C Klahre P | 2003 | Colloids and SurfacesA : Physicochemical Engineering Aspects2003，230，123： | 1 |
| 6 | Relationships between size, mantle area and zooxanthellae numbers in five species of giant clam Cf'ridacnidae)显示文摘 | Griffiths C L Klumpp D W | 1997 | Oceanographic Literature Review1997，44，2： | 1 |
| 7 | Cyanobaeterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants显示文摘 | MacKintosh C Beattie K A Klumpp S | 1990 | FEBS Lett1990，264，2： | 1 |
| 8 | Late myocardial enhancement assessed by 64-MSCT in reperfused porcine myocardial infarction:diagnostic accuracy of low-dose CT protocols in comparison with magnetic resonance imaging显示文摘 | Klumpp B Reimann A | 2007 | Euro Radiol2007，17，2： | 1 |
| 9 | Bioindication of air pollution effects near a copper smelter in Brazil using mango trees and soil microbiological properties显示文摘 | KLUMPP A HINTEMANN T SANTANA DIA J | 2003 | Environmental Pollution2003，126，： | 1 |
| 10 | Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells显示文摘 | Klumpp S Selke D Ahlemeyer B | 2002 | Neurochem Int2002，41，： | 1 |
| 11 | Asymmetric simple exclusion processes with diffusive bottlenecks 显示文摘 | KLUMPP S LIPOWSKY R | 2004 | Phys Rev E2004，70，06： | 1 |
| 12 | LIDAR- 3ased hazard avoidance for landing on Mars 显示文摘 | JOHNSON A E KLUMPP A COLLIER J | 2002 | Journal of uidance Control and Dynamies2002，25，6： | 1 |
| 13 | Assessment of myocardial viability in a reperfused porcine model:evaluation of different MSCT contrast protocols in acute and subacute infarct stages in comparison with MRI显示文摘 | Brodoefel H Reimann A Klumpp B | 2007 | J Comput Assist Tomogr2007，31，2： | 1 |
| 14 | Expression of AP1 during cellular differentiation determines human papillomavirus E6/E7expression in stratified epithelial cells显示文摘 | Kyo S Klumpp D J Inoue M | 1997 | J Gen Virol1997，78，： | 1 |
| 15 | Late myocardial enhancement assessed by 64-MSCT in reperfused porcine myocardial infarction: diagnostic accuracy of low-dose CT protocols in comparison with magnetic resonance imaging 显示文摘 | Brodoefel H Klumpp B Reimann A | 2007 | Eur Radiol2007，17，2： | 1 |
| 16 | Sorption of a branched nonylphenol and perfluorooctanoic acid on Yangtze river sediments and their model components显示文摘 | Li CL Ji R Schaffer A Sequaris JM Amelung W Vereeckena H Klumpp E | 2012 | Journal of Environmental Monitor2012，14，10： | 1 |
| 17 | Uropathogenic Eseherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apop- tosis显示文摘 | Klumpp DJ Rycyk MT Chen MC | 2006 | Infection and immunity2006，74，9： | 1 |
| 18 | The terminally redundant, nonpermuted genome of Listeria bacteriophage A511: a model for the SPOl-like myoviruses of gram-positive bacteria显示文摘 | Klumpp J Dorscht J Lurz R | 2008 | J Bacteriol2008，190，17： | 1 |
| 19 | Urothelial cultures support in- tracellular bacterial community formation by uropathogenic Esche- richia coli 显示文摘 | Berry RE Klumpp D J Schaeffer AJ | 2009 | Infect Immun2009，77，7： | 1 |
| 20 | LIDAR- based hazard avoidance for safe landing on mars 显示文摘 | JOHNSON A KLUMPP A COLLIER J | 2001 | The Journal of the Astronautic Sciences2001，29，11： | 1 |
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