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| 1 | 2003年秋冬季西安大气中有机碳和元素碳的理化特征及其来源解析显示文摘2003年9月至2004年2月在西安站点开展了大气PM2.5和PM10中碳气溶胶的连续观测,并采集了三类主要污染来源样品(燃煤,机动车尾气和生物质燃烧)进行对比分析,采用IMPROVE-TOR 方法准确地测量了样品的有机碳(OC),元素碳(EC)及其中的8个碳组分含量.西安秋季和冬季大气 PM2.5中OC的平均含量ρOC分别为(34.1±18.0),(61.9±33.2)μg·m-3,EC的平均含量ρEC为 (11.3±6.9),(12.3±5.3)μg·m-3.OC和EC均主要赋存于PM2.5粒级中.秋季OC和EC的相关性好(R2>0.90),冬季一般(R2=0.66).总碳气溶胶在秋季PM2.5中占(48.8±10.1)%,在冬季也达到了(45.9±7.5)%.所有观测日的ρOC/ρEC比值均大于2.0,秋季PM2.5中ρOC/ρEC平均为3.3,冬季为 5.1,这可能主要与直接排放来源有关.由碳气溶胶的8个碳组分数据,采用绝对主分量分析获得了主要排放来源对总碳的贡献份额,即秋季汽油车尾气占73%,柴油车尾气占23%,生物质燃烧占 4%,而冬季燃煤占了44%,汽油车尾气占44%,生物质燃烧占9%,柴油车占3%。 | 曹军骥 李顺诚 李杨 Judith C.Chow Kochy Fung | 2005 | 自然科学进展2005，15，12： | 66 |
| 2 | NIRF对P53蛋白泛素化作用的研究显示文摘HEK293和HeLa细胞分别被Np95/ICBP90-likeRINGfingerprotein(NIRF)和P53转染后,细胞上清和免疫沉淀产物用SDS-聚丙烯酰胺凝胶电泳免疫印迹法分析;细菌合成GST-P53后,用GSTpull-down技术检测NIRF与P53相互作用;在GST-P53、E1、E2和NIRF体外泛素化反应系统中,检测NIRF对P53的体外泛素化.结果表明:NIRF能与P53相互作用,NIRF不仅能与P53特异性结合,而且还会将P53泛素化,这种相互作用在细胞内和细胞外均能发生.推测NIRF可能是P53的一个新的负调节蛋白. | 段昌柱 蒲淑萍 TSUTOMU MORI HIDEO KOCHI 邱宗荫 | 2006 | 生物化学与生物物理进展2006，33，2： | 12 |
| 3 | Comparison of conventional and inverted A^2/O processes:Phosphorus release and uptake behaviors显示文摘Two full-scale systems operated in parallel,a conventional A 2 /O system consisting of anaerobic,anoxic and oxic compartments in succession and an inverted system consisting of anoxic,anaerobic and oxic compartments without internal recycle,were compared in terms of their phosphorus removal performance,with an emphasis on phosphate(P) release behaviors,using both operational data and simulation results.The inverted system exhibited better long-term phosphorus removal performance(0.2 ± 0.3 vs.0.7 ± 0.7 mg/L),which should be attributed to the higher P release rate(0.79 vs.0.60 kg P/(kg MLSS·day)) in the non-aerated compartments.The P release occurred in both the anoxic and anaerobic compartments of the inverted system,resulting in more efficient P release.Although the abundances of the 'Candidatus Accumulibacter phosphatis' population in the two systems were quite similar((19.1 ± 3.27)% and(18.4 ± 4.15)% of the total microbe(DAPI stained particles) population in the inverted and conventional systems,respectively,by fluorescence in situ hybridization(FISH)),the high-concentration DAPI staining results show that the abundances of the whole polyphosphate accumulating organisms(PAOs) in the aerobic ends were quite different(the average ratios of the poly-P granules to total microbes(DAPI stained particles) were(45 ± 4.18)% and(35 ± 5.39)%,respectively).Both the operational data and simulation results showed that the inverted system retained more abundant PAO populations due to its special configuration,which permitted efficient P release in the non-aerated compartment and better P removal. | Rong Qi Tao Yu Zheng Li Dong Li Takashi Mino Tadashi Shoji Kochi Fujie Min Yang | 2012 | Journal of Environmental Sciences2012，24，4： | 11 |
| 4 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 5 | possible role of soluble fibrin monomer complex after gastroenterological surgery显示文摘AIM To examine the role of soluble fibrin monomer complex(SFMC) in the prediction of hypercoagulable state after gastroenterological surgery.METHODS We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related markers.RESULTS A total of 123 patients were included in the present study. There were no patients with symptomatic VTE. Thirty-five(28%) patients received postoperative anticoagulant therapy. In the multivariate analysis, a high SFMC level on POD 1 was independently associated with D-dimer elevation on POD 7(OR = 4.31, 95%CI: 1.10-18.30, P = 0.03). The cutoff SFMC level was 3.8 μg/ml(AUC = 0.78, sensitivity, 63%, specificity, 89%). The D-dimer level on POD 7 was significantly reduced in high-SFMC patients who received anticoagulant therapy in comparison to highSFMC patients who did not.CONCLUSION The SFMC on POD 1 strongly predicted the hypercoagulable state after gastroenterological surgery than the clinical risk factors and the other fibrin related markers. | Masatoshi Kochi Manabu Shimomura Takao Hinoi Hiroyuki Egi Kazuaki Tanabe Yasuyo Ishizaki Tomohiro Adachi Hirotaka Tashiro Hideki Ohdan | 2017 | World Journal of Gastroenterology2017，23，12： | 3 |
| 6 | Lectin histochemistry of human gliomas显示文摘 | X. -C. Wang N. Kochi E. Tani K. Kaba T. Matsumoto H. Shindo | 1989 | Acta Neuropathologica1989，，2： | 2 |
| 7 | Usefulness of diffusionweighted MRI with echo-planar technique in the ecahation of cellularity in gliomas显示文摘 | Sugahara T Korogi Y Kochi M | 1999 | J Magn Rason Imaging1999，9，： | 1 |
| 8 | Metal ion-free radical reactions: coupling of free radicals 显示文摘 | Kochi J K Rust F F | 1961 | J Am Chem Soc1961，83，8： | 1 |
| 9 | 途上国にぉけゐHIV合并结核症:预防のための疫学と战略显示文摘 | Narain JP Raviglione MC Kochi A | 1993 | 结核と临床1993，26，1： | 1 |
| 10 | Dual primary gastric and colorectal cancer: is the prognosis better for synchronous or metachronous? 显示文摘 | Watanabe M Kochi M Fujii M | 2012 | Am J Clin Oncol2012，35，5： | 1 |
| 11 | Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas显示文摘 | Korogi Y Kochi M | 1998 | Am J Roentgenol1998，17，6： | 1 |
| 12 | Atom-by-atom growth of cadmium sulfide thin films by electroreduction of aqueous Cd2+-SCN-complex 显示文摘 | Kochi Y | 1999 | Journal of Electroanalytical Chemistry1999，473，： | 1 |
| 13 | Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation ofcellularity in gliomas显示文摘 | Sugahara T Korogi Y Kochi M | 1999 | J Magn Reson Imaging1999，9，1： | 1 |
| 14 | Mechanism of the Chromium-Catalyzed Epoxidation of Olefins Role of Oxochromium(V) Cations显示文摘 | Samsel E G Srinivasan K Kochi J K | 1985 | J Am Chem Soc1985，107，25： | 1 |
| 15 | Antidiabetic effect of an acidic polysaccharide (TAP) from Tremella aurantia and its degradation product (TAP-H)显示文摘 | Kiho T Kochi M Usui S | 2001 | Biol Pharm Bull2001，24，12： | 1 |
| 16 | Neoadjuvant chemotherapy with S-1 and CDDP in advanced gastric cancer显示文摘 | Kochi M Fujii M Kanamori N | 2006 | J Cancer Res Clin Oncol2006，132，12： | 1 |
| 17 | Non-smooth non-negative matrix factorization ( nsNMF ) 显示文摘 | Pascual-Montano A Carazo JM Kochi K | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，： | 1 |
| 18 | HIV-associated tuberculosis in developing countries: epidemiology and strategies for prevention显示文摘 | Narain JP Raviglione MC Kochi A | 1992 | Tubercle Lung Disease1992，73，： | 1 |
| 19 | A regulatory variant in CCR6is associated with rheumatoid arthritis susceptibility 显示文摘 | Kochi Y Okada Y Suzuki A | 2010 | Nat Genet2010，42，6： | 1 |
| 20 | Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases显示文摘 | Shoda H Fujio K Yamaguchi Y Okamoto A Sawada T Kochi Y and Yamamoto K | | 0，，06： | 1 |
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