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| 1 | IFN-a production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and-independent pathways显示文摘Understanding the defense mechanisms of the host of an organism is important for infection control.In previous studies,we demonstrated that interferon-a(IFN-a),but not IL-12,was produced by human peripheral blood mononuclear cells infected with varicella-zoster virus(VZV).Here,we investigated what kind of cell(s)and which signal molecule(s)are involved in IFN-a production.Using cell isolation and ELISA,we found that plasmacytoid dendritic cells(pDCs)were responsible for IFN-a production during VZV infection.We also found that Toll-like receptor 9(TLR9)was involved in VZV-induced IFN-a production because inhibitory CpG oligodeoxynucleotide inhibited IFN-a production.UV-inactivated VZV-induced IFN-a production was lower than that of active VZV,indicating another TLR9-independent pathway.Further studies demonstrated that double-stranded RNA-dependent protein kinase,but not DNA-dependent protein kinase was involved in VZV-induced IFN-a production.Together,these results suggest that pDCs play an important role in IFN-a production during VZV infection through TLR9-dependent and-independent pathways. | Hong-Ren Yu Hsin-Chun Huang Ho-Chang Kuo Jiunn-Ming Sheen Chia-Yo Ou Te-Yao Hsu Kuender D Yang | 2011 | Cellular & Molecular Immunology2011，8，2： | 7 |
| 2 | Recruitment of mesenchymal stem cells and expression of TGF-β1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats显示文摘 | Yeung-Jen Chen Tilmann Wurtz Ching-Jen Wang Yur-Ren Kuo Kuender D Yang Hue-Chen Huang Feng-Sheng Wang | 2003 | Journal of Orthopaedic Research2003，，3： | 2 |
| 3 | Dielectric properties of three ceramic/epoxy composites显示文摘 | Kuo D H Chang C C Su T Y | 2004 | Mater Chem Phys2004，85，1： | 1 |
| 4 | Effects of arecoline in relaxing human umbilical vessels and inhibiting endothelial cell growth显示文摘 | Kuo F C Wu D C Yuan S S | 2005 | J Perinat Med2005，33，5： | 1 |
| 5 | Autocatalytic Processing of Heme by Lactoperoxidase Produces the Native Protein - bound Prosthetic Group 显示文摘 | DEPILLIS G D OZAKI S - I KUO J M | 1997 | Journal of Biological Chemistry1997，272，14： | 1 |
| 6 | The L(2,1)-labeling problem on graphs显示文摘 | CHANG G KUO D | 1996 | SIAM J Disc Math1996，9，： | 1 |
| 7 | Numerical modeling of non-adiabatic heat-recirculating combustors显示文摘 | Kuo C H Ronney P D | 2007 | Proceedings of the Combustion Institute2007，31，2： | 1 |
| 8 | Enzymes of sucrose and hexose metabolism in developing kernals of two inbreds of maize显示文摘 | DOUGLAS C D KUO T M FELKER F C | 1988 | Plant Physiol1988，86，： | 1 |
| 9 | Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria 显示文摘 | Yoshida M Kobayashi K Kuo T T Bry L Glickman J N Claypool S M Kaser A Nagaishi T Higgins D E Mizoguchi E Wakatsuki Y Roopenian D C Mizoguchi A Lencer W I and Blumberg R S | 2006 | The Journal of Clinical Investigation2006，116，： | 1 |
| 10 | Pu-erh tea attenuates hyperli- pogenesis and induces hepatoma cells growth arrest through acti- vating AMP-Activated protein kinase (AMPK) in human HepG2 cells显示文摘 | Way T D Lin H Y Kuo D H | 2009 | J Agric Food Chem2009，57，12： | 1 |
| 11 | Regulatory function of CpG-activated B cells in late-phase experimental allergic conjunctivitis 显示文摘 | Miyazaki D Kuo CH Tominaga T | 2009 | Invest Ophthalmol Vis Sci2009，50，： | 1 |
| 12 | Activation of arylhydrocarbon receptor induces vascular inflammation and promotes atheroscle- rosis in apolipoprotein E-1-mice显示文摘 | Wu D Nishimura N Kuo V | 2011 | Arterioscler Thromb Vase Biol2011，31，6： | 1 |
| 13 | Parallel-machine scheduling with time dependent processing times显示文摘 | KUO W H YANG D L | 2008 | Theor Comput Sci2008，，： | 1 |
| 14 | A covariance estimation for small sample size classification problems and its application to feature extraction显示文摘 | Kuo B C Landgrebe D A | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，4： | 1 |
| 15 | Shock wave lithotripsy monotherapy for renal calculi显示文摘 | Paterson R F Lifshitz D A Kuo R L | 2002 | Int Braz J Urol2002，28，4： | 1 |
| 16 | An optimal control model for analyzing human postural balance 显示文摘 | Kuo A D | 1995 | IEEE Trans Biomed Eng1995，42，： | 1 |
| 17 | ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway显示文摘 | Kuo H P Lee D F Chen C T | 2010 | SciSignal2010，3，108： | 1 |
| 18 | A note on due-date assignment and single-machine scheduling with deteriorating jobs显示文摘 | KUO W H YANG D L | 2008 | J Oper Res Soc2008，59，6： | 1 |
| 19 | Taxonomic revision of true morels(Morchella)in Canada and the United States显示文摘 | Kuo M Dewsbury D R O’Donnell K | 2012 | Mycologia2012，104，5： | 1 |
| 20 | Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet显示文摘 | KUO D H YEH C H SHIEH P C | 2009 | Journal of Etlmopharmacology2009，124，3： | 1 |
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