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| 1 | 二十碳五烯酸对三种肝癌细胞系作用的实验研究显示文摘目的 探讨二十碳五烯酸 (eicosapentaenoicacid ,EPA)对 3种肝癌细胞系作用。方法EPA作用于HepG2 (携带有野生型p5 3基因 )、Huh7(携带有突变型p5 3基因 )和Hep3B(p5 3基因缺失 )这 3种肝癌细胞系 ,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这 3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长 ,而且这种抑制作用呈现出时间和剂量依赖的关系 ,而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制 ,而且p5 3基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 | 王蓬 陈孝平 PBS Lai CK leow Joseph W Y Lau | 2001 | 中华普通外科杂志2001，16，1： | 4 |
| 2 | Automated Sequencing and Subassembly Detection in Automobile Body Assembly Planning显示文摘The choice of the sequence in which parts or subass em blies are put together in the mechanical assembly of a product can drastical ly affect the efficiency of the assembly process. Unlike metal cutting operation s where computer aided system have been available for some 15 to 25 years to hel p manufacturing engineers in generating cutting sequences and NC programs, the m ajority of assembly planning tasks in automobile body design is still manually p erformed by assembly designers according to their past experiences. This has prolonged the production lead time and time to market. This paper describes a p rocedure to automatically derive all the feasible assembly sequences for automob ile body assembly. The procedure is based on a mathematical model of the automob ile body, obtained through the definitions of the connection matrix and contract ed matrix. These two matrices represent the precedence constraint knowledge amon g components and subassemblies. The possible subassemblies are automatically det ected by satisfying some mathematical conditions applicable to these matrices. F or each subassembly and the whole product, all the possible assembly sequences a re generated by rearranging the initial connection sub-matrix and the contracte d matrix. The procedure is applicable to compliant component assemblies, suc h as the automobile body assembly, aircraft frame assembly, and can solve the 'combinatorial explosion' problem efficiently. | ZHANG Yi-zhu 1, NI Jun 2, LIN Zhong-qin 1, LAI Xin-min 1 (1. Institute of Mechanics and Engineering, Shanghai Jiaotong Universit y, Shanghai 200030, China 2. Department of Mechanical Engineering, The University of Michigan, Michigan, U SA) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 3 |
| 3 | Jack Hills锆石的安山质源区支持板块构造始于冥古代显示文摘地球最老的地壳组成和构造属性是地球科学研究中两个最基本的问题,但是由于缺乏合适年龄的岩石,难以进行约束。很多研究主要集中于西澳Jack Hills变质沉积岩中4.4~4.3 Ga的碎屑锆石,但是对其原岩性质的认识依然缺乏共识。对其原岩成分的推断主要基于锆石的Hf同位素组成,研究者普遍认为这些碎屑锆石来源于火成岩源区。 | Turner S Wilde S Worner G Schaefer B Lai Y J 袁超(编译) | 2020 | 矿物岩石地球化学通报2020，39，3： | 2 |
| 4 | Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin显示文摘 | Y Ding J Li X Luan Y.H Ding Q Lai J.A Rafols J.W Phillis J.C Clark F.G Diaz | 2004 | Neuroscience2004，，3： | 2 |
| 5 | In situ TiB 2 reinforced Al alloy composites显示文摘 | L Lü M.O Lai Y Su H.L Teo C.F Feng | 2001 | Scripta Materialia2001，，9： | 2 |
| 6 | Preparative separation and determination of matrine from the chinese medicinal plant Sophora flavescens air by molecularly imprinted solid phase extraction显示文摘 | Lai JP He XW Jiang Y | | 0，，02： | 2 |
| 7 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 8 | Does dying at home influence the good death of terminal cancer patients? 显示文摘 | Yao C A Hu W Y Lai Y F | 2007 | J Pain Symptom Manage2007，34，5： | 1 |
| 9 | Tarsal sinus: arthrographic, MR imaging, MR arthrographic, and pathologic findings in cadavers and retrospective study data in patients with sinus tarsi syndrome显示文摘 | Lektrakul N Chung C B Lai Y M | 2001 | Radiology2001，219，6： | 1 |
| 10 | Connectivity distribution and attack tolerance of general networks with both preferential and random attachments显示文摘 | Liu Y C Lai Y C Ye N | 2002 | Physics Letters A2002，303，： | 1 |
| 11 | High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma : significance of hepatitis virus infection ,age ,p53 ,and beta-catenin mutations显示文摘 | PENG S Y CHEN W J LAI P L | 2004 | Int J Cancer2004，112，1： | 1 |
| 12 | Mathematical modelling of elliptic helicoid screw transmission systems显示文摘 | Wu D S Lai H Y Chen C K | 2002 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2002，216，2： | 1 |
| 13 | Matrix profile and wavefront reduction based on the graph theory and wavefront minimization显示文摘 | Lai Y C Weingarten V I Eshraghi H | 1996 | International Journal for Numerical Methods in Engineering1996，39，7： | 1 |
| 14 | Neural network models for product image design显示文摘 | Lin Y C Lai H H Yeh C H | 2004 | Knowledge-Based Intelligent Information and Engineering Systems2004，，3215： | 1 |
| 15 | Chin Tradit Pat Med 显示文摘 | Liu Z Q Lai X P Wu Y H | 2001 | 23(8): 550-5522001，23，8： | 1 |
| 16 | Comparison of the Population Capacity of Hematopoietic and Mesenchymal Stem Cells in Experimental Colitis Rat Model显示文摘 | Wei Y M Nie Y Q Lai J Y | 2009 | Transplantation2009，88，1： | 1 |
| 17 | Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population显示文摘 | Wang ML Lai JH Zhu Y | 2009 | Int J Immunogenet2009，36，4： | 1 |
| 18 | AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense 显示文摘 | Lai Y Gallo RL | 2009 | Trends Immunol2009，30，3： | 1 |
| 19 | Banana biomass as potential renewable energy resource: A Malaysian case study 显示文摘 | TOCK J Y LAI C L LEE K T | 2010 | Renewable and Sustainable Energy Re- views2010，14，2： | 1 |
| 20 | Functional and structural characterization of recombinant dermcidin-1L,a human antimicrobial peptide显示文摘 | Lai YP Peng YF Zuo Y | 2005 | Biochemical and Biophysical Research Communications2005，328，： | 1 |
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