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| 1 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 2 | Social factors in second language attrition显示文摘 | Gardner R C Lalonde R N MacPherson J | | 0，，04： | 2 |
| 3 | Convergence of Electric Bands for High Performance Bulk Thermoelectrics 显示文摘 | Pei Y Shi X LaLonde A | 2011 | Nature2011，473，7345： | 1 |
| 4 | Early bum excision attenuates the postbum lung and systemic response to endotoxin 显示文摘 | Demling RH LaLonde C | 1990 | Surgery1990，108，1： | 1 |
| 5 | A practical guide to wound heal- ing 显示文摘 | Janis JE Kwon RK LaLonde DH | 2010 | Plast Reconstr Surg2010，125，6： | 1 |
| 6 | The promise of public sector sponsored training programs显示文摘 | Robert J LaLonde | 1995 | Journal of Economic Perspectives1995，9，2： | 1 |
| 7 | MOC -PSSM CME Article: Breast Reconstruction 显示文摘 | SIGURDSON L LALONDE D H | 2008 | Plast Reconstr Surg2008，121，： | 1 |
| 8 | Reevaluation of PbTel -xlx as High Performance n-type Thermoelectric material 显示文摘 | LaLonde A D Pei Y Snyder G J | 2011 | Energy & Envi- ronmental Science2011，4，6： | 1 |
| 9 | Altered protein synthesis during oat leaf senescence 显示文摘 | Lalonde L Dhindsan R S | 1990 | Physiol Plant1990，80，： | 1 |
| 10 | Topiramate reduces energy and fat gains in lean(Fa/?) and obese(fa/fa) Zucker rats显示文摘 | Picard F Deshaies Y Lalonde J | 2000 | Obes Res2000，8，： | 1 |
| 11 | Second language attrition:The role of motivation and use显示文摘 | Gardner R.C Lalonde R.N Moorcroft R Evers F.T | | 0，，： | 1 |
| 12 | Photooxidation of Hg (0) in artificial and natural waters 显示文摘 | Lalonde J D Amyot M Kraepiel A | 2001 | Environmental Science & Technology2001，35，： | 1 |
| 13 | The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cells显示文摘 | Lodge R Lalonde JP Lemay G Cohen EA | 1997 | EMBO J1997，16，4： | 1 |
| 14 | Early postbum lipid peroxidation (effect of ibuprofen and allopurinol ) 显示文摘 | Demling R H Lalonde C | 1990 | Surgery1990，107，1： | 1 |
| 15 | Activemanagement of the third stage of labour:prevention andtreatment of postpartum hemorrhage显示文摘 | LEDUC D SENIKAS V LALONDE A B | 2009 | J Obstet Gynaecol Can2009，31，10： | 1 |
| 16 | Exposure-Response Analysis in Patients With Schizophrenia to Assess the Effect of Asenapine on QTc Prolongation显示文摘 | Sunny Chapel Matt M. Hutmacher George Haig Howard Bockbrader Rik de Greef Sheldon H. Preskorn Richard L. Lalonde | 2009 | Journal of Clinical Pharmacology2009，，： | 1 |
| 17 | Biomechanical compar-ison of stainless steel and titanium nails for fixation of simu-lated femoral fractures显示文摘 | Mahar AT Lee SS Lalonde FD | 2004 | Pediatr Orthop2004，24，6： | 1 |
| 18 | Specific amplification of 18S fungal ribosomal genes from vesicular-arbuscular mycorrhizal fungal communities显示文摘 | Simon L Lalonde M Bruns TD | 1992 | Applied and Environmental Microbiology1992，58，1： | 1 |
| 19 | Active manage- ment of the third stage of labour:prevention and treatment of postpartum hemorrhage显示文摘 | LEDUC D SENIKAS V LALONDE AB | 2009 | Joumal of Obstetrics Gynaecology Cana- da2009，31，10： | 1 |
| 20 | Evaluating antipsychotic medications:predictors of clinical effectiveness显示文摘 | Lalonde P | 2003 | Can J Psychiatry2003，48，3： | 1 |
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