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| 1 | Lean techniques for the improvement of patients' flow in emergency department显示文摘BACKGROUND: Emergency departments(EDs) face problems with overcrowding, access block, cost containment, and increasing demand from patients. In order to resolve these problems, there is rising interest to an approach called 'lean' management. This study aims to(1) evaluate the current patient flow in ED,(2) to identify and eliminate the non-valued added process, and(3) to modify the existing process.METHODS: It was a quantitative, pre- and post-lean design study with a series of lean management work implemented to improve the admission and blood result waiting time. These included structured re-design process, priority admission triage(PAT) program, enhanced communication with medical department, and use of new high sensitivity troponin-T(hsTnT) blood test. Triage waiting time, consultation waiting time, blood result time, admission waiting time, total processing time and ED length of stay were compared.RESULTS: Among all the processes carried out in ED, the most time consuming processes were to wait for an admission bed(38.24 minutes; SD 66.35) and blood testing result(mean 52.73 minutes, SD 24.03). The triage waiting time and end waiting time for consultation were significantly decreased. The admission waiting time of emergency medical ward(EMW) was significantly decreased from 54.76 minutes to 24.45 minutes after implementation of PAT program(P<0.05).CONCLUSION: The application of lean management can improve the patient flow in ED. Acquiescence to the principle of lean is crucial to enhance high quality emergency care and patient satisfaction. | HY Chan SM Lo LLY Lee WYL Lo WC Yu YF Wu ST Ho RSD Yeung JTS Chan | 2014 | World Journal of Emergency Medicine2014，5，1： | 6 |
| 2 | TLR-3启动子区功能性基因多态性与骨关节炎的相关性:两阶段病例对照研究显示文摘骨关节炎(osteoarthritis,OA)被认为是多因素疾病,目前有关其遗传因素的研究涉及了遗传方式及基因组的潜在突变位置等。最近的报道显示,Toll样受体(toll-like receptor,TLR)家族与OA的发生发展关系密切。单核苷酸多态性(single nucleotide polymorphisms,SNPs)在TLR基因中普遍存在,并对TLR功能产生影响。前期研究证实,TLR-9基因的(-1486T/C)启动子多态性与末期膝OA有关,而作为同属于核内体TLR、均以病原相关分子方式来识别病毒和细菌核酸的TLR-3,7,8,其功能性基因多态性是否与中国汉族人群膝OA有关,是本研究的主要目的。 | Yang HY Lee HS Lee CH 白朝晖 章莹 | 2013 | 中国骨科临床与基础研究杂志2013，5，6： | 3 |
| 3 | 二硫化碳慢性接触对儿茶酚胺类代谢的影响显示文摘采用综合累积暴露指数(ICE),将工人接触CS2浓度和接触期限结合起来定量评价暴露强度,并检测尿中2-硫代噻唑烷-4-羧酸(TTCA)和儿茶酚胺类神经递质代谢产物的含量。结果显示:接触组尿中TTCA增高,存在剂量-效应关系;高接触组高香草酸(HVA)和香草扁桃酸(VMA)排泄减少。这两种儿茶酚胺代谢产物与CS2浓度及工龄虽未显示有显著意义的相关,但与ICE及TTCA之间却呈现统计学上的相关关系,表明长期接触CS2对儿茶酚胺类神经递质代谢有一定的干扰作用。 | 杨杏芬 庄志雄 马林 谭炳炎 Lee BL New AL Ong HY Ong CN | 1996 | 中华劳动卫生职业病杂志1996，14，1： | 3 |
| 4 | Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma 显示文摘 | Lee MG Kim HY Byun DS | 2001 | Cancer Res2001，61，： | 1 |
| 5 | Changes in gene cassettes of class 1 integrons among Escherichia coli isolates from urine specimens collected in Korea during the last two decades显示文摘 | Yu HS Lee JC Kang HY | 2003 | J Clin Microbiol2003，41，12： | 1 |
| 6 | The differential proteome profile of stomach cancer:identification of the biomarker candidates显示文摘 | Jang JS Cho HY Lee YJ | 2004 | Oncol Res2004，14，10： | 1 |
| 7 | CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteoclastogenesis evidence of NF-kappa B-dependent,CD40-mediated bone destruction in rheumatoid arthritis显示文摘 | Lee HY Jeon HS Song EK | 2006 | Arthritis Rheum2006，54，6： | 1 |
| 8 | Involvement of matrix metalloproteinase in neuroblast cell migration from the subven- tricular zone after stroke显示文摘 | Lee SR Kim HY Rogowska J | 2006 | J Neurosci2006，26，13： | 1 |
| 9 | Retrievable covered nitinol stents: experiences in 108 patients with malignant esophageal stricture 显示文摘 | Song HY Lee DH Seo TS | 2002 | Vasc inter Radio2002，13，3： | 1 |
| 10 | Myocardial infarction:the MAGIC cell-3-DES randomized,controlled trial and remodeling in patients with acute myocardial infarction versus old cells by granulocyte colony-stimulating factor on left ventricular function differential effect of intracoronary infusion of mobilized peripheral blood stem显示文摘 | Kang HJ Lee HY Na SH | 2006 | Circulation2006，114，： | 1 |
| 11 | Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation显示文摘 | Ho HY Lee RK Hwu YM | 2002 | J Assist Reprod Genet2002，19，11： | 1 |
| 12 | Melatonin attenu- ates gray and white matter damage in a mouse model of transient focal cerebral ischemia 显示文摘 | Lee EJ Lee MY Chen HY | 2005 | J Pineal Res2005，38，1： | 1 |
| 13 | MDCT evaluation of acute aortic syndrome显示文摘 | Yoo SM Lee HY White CS | 2010 | Radiol Clin North Am2010，48，1： | 1 |
| 14 | Secondary structure of mitochondrial 12S rRNA among fish and its phylogenetic applications 显示文摘 | Wang HY Lee SC | 2002 | Mol Biol Evol2002，19，2： | 1 |
| 15 | Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma Invading the main portal vein and may improve the overall survival显示文摘 | Chung GE Lee JH Kim HY | 2011 | Radiology2011，258，2： | 1 |
| 16 | Gastric schwannoma 显示文摘 | Yoon HY Kim CB Lee YH et M | 2008 | Yonsei Med J2008，49，6： | 1 |
| 17 | Blocking of monocyte-associated B7-H1 (CD274)enhances HCV-specific T cell immunity in chronic hepatitis C infection 显示文摘 | Jeong HY Lee Y J Seo SK | 2008 | J Leukoc Biol2008，83，3： | 1 |
| 18 | MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits显示文摘 | Lee JE Hong EJ Nam HY | | 0，，01： | 1 |
| 19 | Laparoscopic repair of vesicovaginal fistula显示文摘 | Tiong HY Shim T Lee YM | | 0，，04： | 1 |
| 20 | Chemokine receptor CXCR4 expression,function,and clinical implications in gastric cancer显示文摘 | Lee HJ Kim SW Kim HY | | 0，，： | 1 |
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