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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Visualizing the microtubule-associated protein tau in the nucleus显示文摘Although tau is mainly known as an axonal microtubule-associated protein,many studies indicate that it is not restricted to this subcellular compartment.Assessing tau’s subcellular distribution,however,is not trivial as is evident from transgenic mouse studies.When human tau is over-expressed,it can be immunohistochemically localized to axons and the somatodendritic domain,modeling what is found in neurodegenerative diseases such as Alzheimer’s disease.Yet,in wild-type mice,despite its abundance,tau is difficult to visualize even in the axon.It is even more challenging to detect this protein in the nucleus,where tau has been proposed to protect DNA from damage.To establish a framework for future studies into tau’s nuclear functions,we compared several methods to visualize endogenous nuclear tau in cell lines and mouse brain.While depending on the fixation and permeabilization protocol,we were able to detect nuclear tau in SH-SY5Y human neuroblastoma cells,we failed to do so in N2a murine neuroblastoma cells.As a second method we used subcellular fractionation of mouse tissue and found that in the nucleus tau is mainly present in a hypophosphorylated form.When either full-length or truncated human tau was expressed,both accumulated in the cytoplasm,but were also found in the nuclear fraction.Because subcellular fractionation methods have their limitations,we finally isolated nuclei to probe for nuclear tau and found that the nuclei were free of cytoplasmic contamination.Together our analysis identifies several protocols for detecting tau in the nucleus where it is found in a less phosphorylated form. | LU Jing LI Ting HE RongQiao BARTLETT Perry F GTZ Jürgen | 2014 | Science China(Life Sciences)2014，57，4： | 11 |
| 3 | Control of apoptosis and mitotic spindle checkpoint by survivin显示文摘 | Li F Ambrosini G Chu E Y | | 0，，： | 8 |
| 4 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 5 | 显示文摘 | Li Y F He G F | 1998 | Synth Met1998，94，： | 2 |
| 6 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 7 | Theoretical study of BexZn1-xO alloys显示文摘 | Ding S F Fan G H Li S T | 2007 | Physiea B2007，394，： | 1 |
| 8 | Control of apoptosis and mitotic spindle checkpoint by survivin 显示文摘 | Li F Ambrosini G Chu EY | 1998 | Nature1998，396，671： | 1 |
| 9 | Stress corrosion cracking of pipeline steel in soil environments of eastern china显示文摘 | Li G F Huang C B Guo H | 2007 | Key Engineering Materials2007，，： | 1 |
| 10 | Massive training artificial neural network (MTANN) for reduction of false positives in computerized detection of lung nodules in low-dose computed tomography显示文摘 | SUZUKI K ARMATO S G LI F | 2003 | Med Phys2003，30，7： | 1 |
| 11 | Cooperative expression of survival p -ERK and p-Akt signals in rat brain neurons after transient MCAO显示文摘 | Li F Ornori N Jin G | 2003 | Brain Res2003，962，12： | 1 |
| 12 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Nelssen J L Reddy P G | 1990 | J Anim Sci1990，68，6： | 1 |
| 13 | Sequence-related amplified polymorphism (SRAP),a new marker system based on a simple PCR reaction:its application to mapping and gene tagging in Brassica显示文摘 | Li G Quiros C F | 2001 | Theoretical and Applied Genetics2001，103，： | 1 |
| 14 | 3-D position sensitive CdZnTe gamma ray spectremeters显示文摘 | He Z Li W Knoll G F | 1999 | Nucl Instr and Meth in Phys Res1999，422，： | 1 |
| 15 | Heat load behaviors of plasma sprayed tungsten coatings on copper alloys with different compliant layers 显示文摘 | Chong F L Chen J L Li J G | 2008 | Journal of Nuclear Materials2008，375，： | 1 |
| 16 | Control of apoptosis and mitotic spindle checkpoint by survivin 显示文摘 | Li F Ambrosini G Chu EY | 1998 | Nature1998，396，6711： | 1 |
| 17 | Alternative block poly- urethanes based on poly(3-hydroxybutyrate-co-4-hydroxybu- tyrate) and poly(ethylene glycol) 显示文摘 | PAN J Y LI G Y CHEN Z F | 2009 | Biomaterials2009，30，16： | 1 |
| 18 | Chaotic Oscillations System Ofconstrained Pipe Conveying Fluid 显示文摘 | Paidoussis M P Li G X Moon F C | 1989 | Journal of Sound and Vibration1989，135，1： | 1 |
| 19 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Li D F Nelssen J L Reddy P G | 1990 | Animal Science1990，68，： | 1 |
| 20 | An energy efficient clustering scheme in wireless sensor networks显示文摘 | M Ye C F Li G H Chen J Wu | 2007 | International Journal of Ad Hoc & Sensor Wireless Networks2007，3，2： | 1 |
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