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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 3 | Changes in uhrastructure and abscisic acid level and response to applied gibberellins in Taxus rnalrei seeds treated with warm and cold stratification显示文摘 | CHING T C LING L H TSAN P L | 1998 | Annals of Botany1998，81，： | 1 |
| 4 | Pullulanase:role in starch hydrolysis and potential industrial applica-tions显示文摘 | Hii S L Tan J S Ling T C | 2012 | Enzyme Res2012，，： | 1 |
| 5 | The effects of shopping orientations, online trust and prior online pur- chase experience toward customers' online purchase inten- tion显示文摘 | Ling K C Chai L T Piew T H | 2010 | International Business Research2010，3，3： | 1 |
| 6 | SIMS depth,profiling analysis of electrical are residues infire investigation显示文摘 | Chen C Y Ling Y C Wang J T | 2003 | Applied Surface Science2003，，203： | 1 |
| 7 | Recognition of Grenvillian volcanic suite in the Shennongjia region and its tectonic significance for the South China Craton 显示文摘 | Qiu X F Ling W L Liu X M Kusky T Berkana W ZhangY H Gao Y J Lu S S Kuang H Liu C X | 2011 | Precambrian Research2011，191，： | 1 |
| 8 | Single-ion gibbs energies, enthalpies and entropies of transfer from water to aqueous methanol bases on the (Ph4P, Ph4As ) = Ph4B- assumption显示文摘 | ABRAHAM M H HILL T LING H C | 1984 | Journal of the Chemi- cal Society-Faraday Transactions I1984，80，2： | 1 |
| 9 | SIMS depth profiling analysis of electrical arc residues in fire investigation显示文摘 | Chen C Y Ling Y C Wang J T | 2003 | Applied Surface Science2003，，： | 1 |
| 10 | Adsorption of polyethyleneglycol (PEG) from aqueous solution onto hydrophobic zeolite 显示文摘 | Chang C Y Tsai W T Ling C H | 2003 | Journal of Colloid and Interface Science2003，260，2： | 1 |
| 11 | Estimates of bottom rough- ness length and bottom shear stress in South San Francisco Bay Cali- fornia显示文摘 | Ralph T C Ling C H Gartner J W | 1999 | Journal of Geophysical Research1999，104，7： | 1 |
| 12 | A Mathematical programming model for water usage and treatment network design 显示文摘 | Huang C H Chang C T Ling H C | 1999 | Industri- al and Engineering Chemistry Research1999，38，7： | 1 |
| 13 | Identification of pulmonary Oct-4+stem/progenitor cells and demonstration of their susceptibility to SARS coronavims (SARS-CoV) infection in Vitro显示文摘 | KUO M D LI C L | 2006 | Proc Natl Acad Sci U S A2006，103，25： | 1 |
| 14 | Biohashing: two factor authentication featuring fingerprint data and tokenised random number显示文摘 | JIN A T B LING D N C GOH A | 2004 | Pattern recognition2004，37，11： | 1 |
| 15 | Image Retrieval Based on Object's Orientation Spatial Relationalship显示文摘 | Zhou X M Ang C H Ling T W | 2001 | PRL2001，22，5： | 1 |
| 16 | Influence of nano-scale dopants of Pt, CaO and SiO2 on the alcohol sensing of SnO2 thin films显示文摘 | Ling T R Tsai C M | 2006 | Sensors and Actuators B2006，119，2： | 1 |
| 17 | Over expression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular en- dothelial growth factor (VEGF) 显示文摘 | Ling M T Lau T C Zhou C | 2005 | Carcinogenesis2005，26，10： | 1 |
| 18 | An approximate analysis of the three-dimensional effects of diaphragm wall installation 显示文摘 | Ng C W W Lings M L Simpson B & Nash D F T | | Geotechnique0，45，3： | 1 |
| 19 | Id-1 expression and cell survival显示文摘 | Wong Y C Wang X Ling M T | 2004 | Apoptosis2004，9，3： | 1 |
| 20 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
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