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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Leber's hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families显示文摘 | Zhou XT Wei QP Yang L Tong Y Zhao FX Lu CJ Qian YP Sun YH Lu F Qu J Guan MX | 2006 | 中国生物学文摘2006，20，4： | 18 |
| 3 | Visualizing the microtubule-associated protein tau in the nucleus显示文摘Although tau is mainly known as an axonal microtubule-associated protein,many studies indicate that it is not restricted to this subcellular compartment.Assessing tau’s subcellular distribution,however,is not trivial as is evident from transgenic mouse studies.When human tau is over-expressed,it can be immunohistochemically localized to axons and the somatodendritic domain,modeling what is found in neurodegenerative diseases such as Alzheimer’s disease.Yet,in wild-type mice,despite its abundance,tau is difficult to visualize even in the axon.It is even more challenging to detect this protein in the nucleus,where tau has been proposed to protect DNA from damage.To establish a framework for future studies into tau’s nuclear functions,we compared several methods to visualize endogenous nuclear tau in cell lines and mouse brain.While depending on the fixation and permeabilization protocol,we were able to detect nuclear tau in SH-SY5Y human neuroblastoma cells,we failed to do so in N2a murine neuroblastoma cells.As a second method we used subcellular fractionation of mouse tissue and found that in the nucleus tau is mainly present in a hypophosphorylated form.When either full-length or truncated human tau was expressed,both accumulated in the cytoplasm,but were also found in the nuclear fraction.Because subcellular fractionation methods have their limitations,we finally isolated nuclei to probe for nuclear tau and found that the nuclei were free of cytoplasmic contamination.Together our analysis identifies several protocols for detecting tau in the nucleus where it is found in a less phosphorylated form. | LU Jing LI Ting HE RongQiao BARTLETT Perry F GTZ Jürgen | 2014 | Science China(Life Sciences)2014，57，4： | 11 |
| 4 | Hypoxia-associated induction of early growth response-1 gene expression 显示文摘 | Yan S F Lu J Zou Y S | 1999 | J Biol Chem1999，274，15： | 2 |
| 5 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 6 | Study on scaling of mechanically alloyed and hot pressed NbCr2 Laves phase at 1 200 ℃ in air显示文摘 | ZHENG H Z LU S Q SU Q QUAN F J | 2008 | Int J Refr Metals Hard Mater2008，26，1： | 1 |
| 7 | A receive space diversity architecture for OFDM systems using orthogonal designs 显示文摘 | Huang D F Letaief B K Lu J H | 2004 | IEEE Transactions on Wireless Communications2004，3，3： | 1 |
| 8 | Increased serum glycated albumin level is associated with the presence and severity ofcoronary artery disease in type 2 diabetic patients显示文摘 | PU L J LU L SHEN W F | 2007 | Circ J2007，71，7： | 1 |
| 9 | Piecewise-Koszul algebras 显示文摘 | Lu J F He J W Lu D M | 2007 | Scinece in China Series A: Mathematics2007，50，： | 1 |
| 10 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 11 | Evaluation of screening methods for demulsifying bacteria and characterization of lipopeptide bio-demulsifier produced by Alcaligenes sp显示文摘 | Huang X F Liu J Lu L J | 2009 | Bioresource Technology2009，100，3： | 1 |
| 12 | An XML multi-signature scheme显示文摘 | LU E J L CHEN R F | 2004 | Applied Mathematics and Computation2004，，149： | 1 |
| 13 | The MOS 36-Item Short-Form Health Survey (SF-36) : Ⅲ : Tests of data quality, scaling assumptions and reliability across diverse patient groups显示文摘 | Mcklorney C A Ware J E Lu J F R | 1994 | Med Care1994，32，1： | 1 |
| 14 | Oxidative damage to mitochondrial DNA and activity of mitochodrial enzymes in chronic active lesions of multiple sclerosis显示文摘 | Lu F Selak M Commor J | 2000 | J Neurol Sci2000，177，2： | 1 |
| 15 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 16 | A method to choose ker- nel function and its parameters for support vector ma- chines显示文摘 | Liu H J Wang Y N Lu X F | 2005 | Mach Learning Cybernet2005，7，： | 1 |
| 17 | The Young、modulus ofchromium nitride films 显示文摘 | Chen H Y Tsai C J Lu F H | 2004 | Surf Coat Techn2004，184，1： | 1 |
| 18 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 19 | A novel alkaline and low-temperature lipase of Burkholderia cepacia isolated from Bohai in China for detergent formulation 显示文摘 | Wang H K Liu R J Lu F P | 2009 | Annals of Microbiology2009，59，1： | 1 |
| 20 | Process modeling based on process similarity 显示文摘 | Lu J Gao F | 2008 | Industrial & Engineering Chemistry Research2008，47，： | 1 |
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