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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 肝细胞来源外泌体可能成为慢加急性肝衰竭患者肝再生和预后评估的生物标志物显示文摘【据Hepatology International 2021年8月报道】题:肝细胞来源外泌体可能成为慢加急性肝衰竭患者肝再生和预后评估的生物标志物(作者Jiao Y等)慢加急性肝衰竭(ACLF)患者虽然肝损伤严重,但是部分患者仍可以通过肝脏再生得以存活,因此ACLF患者的肝再生评估尤为重要。外泌体兼具肝脏活组织检查的特异性和外周血检测的非侵袭性的优点,可能是肝脏疾病潜在的生物标志物。本研究旨在建立ACLF肝再生的外泌体表达谱模型,探讨其在肝衰竭患者肝再生及预后评估中的作用。 | JIAO Y LU W XU P 焦彦 卢旺 陈煜 时红波 马迎民 | 2021 | 临床肝胆病杂志2021，37，10： | 8 |
| 3 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 4 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | A Sequential Learning Scheme for Function Approximation by Using Minimal Radial Basis Function Networks 显示文摘 | Lu Y Sundararajan N Saratchandran P | 2007 | Neural Computation (S0899-7667)2007，19，2： | 1 |
| 7 | Thermal stability of recorded information at high densities显示文摘 | Charap S H Lu P L He Y J | 1997 | IEEE Trans Magn1997，33，1： | 1 |
| 8 | δ-catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles显示文摘 | ZENG Y ABDALLAH A LU J P | 2009 | Molecular Cancer2009，8，1： | 1 |
| 9 | Characterization of a novel thermophilic lipase with positional non-specificity from Burkholderia cepacia显示文摘 | Lu Y P Lu F X Wang X | 2009 | Ann Microbiol2009，59，3： | 1 |
| 10 | The effect of monopolar radiofrequency energy on partial-thickness defects of articular cartilage 显示文摘 | Lu Y Hayashi K Hecht P | 2000 | Arthroscopy2000，16，5： | 1 |
| 11 | Glucose-insulin-potassium preserves systolic and diastolic function in ischemia and reperfusion in pigs 显示文摘 | Zhu P Lu L Xu Y | 2000 | Am J Physiol Heart Circ Physiol2000，278，2： | 1 |
| 12 | Expression of cyclooxygenase-2 (Cox-2) in human esophageal cancer and in vitro inhibition by a specific Cox-2 inhibitor, NS-398 显示文摘 | Yu H P Shi L Y Lu W H | 2004 | J Gastroenterol Hepatol2004，19，6： | 1 |
| 13 | Diesel-like hydrocarbons from catalytic deoxygenation of stearic acid over supported Pd nanoparticles on SBA-15 catalysts显示文摘 | LESTARI S MAKI-ARVELA P ERANEN K BELTRAMINI J LU G MURZIN D Y | 2010 | Catal Lett2010，134，34： | 1 |
| 14 | Transfer matrix method for linear multibody system 显示文摘 | Rui X T Wang G P Lu Y Q | 2008 | Multibody System Dynamics2008，19，3： | 1 |
| 15 | Long-distance growth and connec- tivity of neural stem cells after severe spinal cord injury 显示文摘 | Lu P Wang Y Graham L | 2012 | Cell2012，150，6： | 1 |
| 16 | Separation ofproanthocyanidins into oligomeric and polymeric components using a novel collagen fiber adsorbent显示文摘 | Lu Y P Liao X P Li J | 2009 | Journal of Liquid Chromatography and Related Technologies2009，32，： | 1 |
| 17 | Synthesis and characterization of Y2O3:Er3+ upconversion materials with nanaporous显示文摘 | Lu Q P Hou Y B Tang A W | | 0，，11： | 1 |
| 18 | CT evaluation of spontaneously ruptured renal angiomyolipomas with massive hemorrhage spreading into multi-retroperitoneal fascia and fascial spaces显示文摘 | Lu C Y Min P Q Wu B | 2012 | Acta Radiol Short Rep2012，1，4： | 1 |
| 19 | Why People Use Social Networking Sites:An Empirical Study Integrating Network Externalities and Moti- vation Theory 显示文摘 | Lin K Y Lu H P | 2011 | Computers in Human Behavior2011，，27： | 1 |
| 20 | Prevalence of diabetes among men and women in China显示文摘 | Yang W Y Lu J M Weng J P | 2010 | New England Journal of Medicine2010，362，： | 1 |
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