|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 3 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | J Phys Chem B2000，104，19： | 1 |
| 5 | Study on scaling of mechanically alloyed and hot pressed NbCr2 Laves phase at 1 200 ℃ in air显示文摘 | ZHENG H Z LU S Q SU Q QUAN F J | 2008 | Int J Refr Metals Hard Mater2008，26，1： | 1 |
| 6 | The Creep-damage Constitutive Life Predictive Model for Nickel-base Single Crystal Superalloys 显示文摘 | Lu Z Z Zheng C Q | 1995 | Metallurgical and Material Transaction1995，26，： | 1 |
| 7 | Activity of β-C2S under different sintering conditions 显示文摘 | Lu Z Y Tan K F | 1997 | Cement and Concrete Research1997，27，7： | 1 |
| 8 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 9 | Some theoretical considerations on wich structures under the dynamic response of sand impulsive loading显示文摘 | Zhu F Wang Z H Lu G X Nurick G | 2010 | Interna tional Journal of Impact Engineering2010，37，6： | 1 |
| 10 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 11 | Line sampling reliability analysis for low cycle fatigue life of aeronautical engine disc structure显示文摘 | Song S F Lu Z Z | 2006 | Key Engineering Materials2006，，： | 1 |
| 12 | Characteristics of or-ganic,nitrogen and phosphorus species released from ultra-sonic treatment of waste activated sludge显示文摘 | Wang X X Qiu Z F Lu S G | 2009 | Journal of Haz-ardous Materials2009，176，3： | 1 |
| 13 | Isolation and character- ization of a Lactobacillus plantarum bacteriophage, ~JL-1, from a cucumber fermentation显示文摘 | Lu Z Breidt Jr F Fleming H | 2003 | Int J Food Microbiol2003，84，2： | 1 |
| 14 | Comparative mapping of QTLs for agronomic traits of rice across environment by using a doubled-haploid population显示文摘 | Lu C F Shen L H Tan Z B | 1997 | Theor Appl Genet1997，94，1： | 1 |
| 15 | Activated anti-tumor immu- nity in cancer patients after high intensity focused ultrasound ablation显示文摘 | Wu F Wang Z B Lu P | 2004 | Ultrasound Med Biol2004，30，9： | 1 |
| 16 | Implication of boron isotope geochemistry for the pedogenic environments in loess and paleosol sequences of central China显示文摘 | Wei H Z Lei F Jiang S Y Lu H Y Xiao Y K Zhang H Z Sun X F | 2015 | Quatern Res2015，83，1： | 1 |
| 17 | Effects of electroacupuncture on etha- nol-induced impairments of spatial learning and memory and Fos ex- pression in the hippocampus in rats显示文摘 | Lu B Ma Z Cheng F | 2014 | Neurosci Lett2014，576，： | 1 |
| 18 | Estimating the number of people at risk for and living with HIV in China in 2005 : Methods and results 显示文摘 | Lu F Wang N Wu Z | 2006 | Sex Transom Infect2006，82，3： | 1 |
| 19 | Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation显示文摘 | Su Z Lin J Lu F | 2013 | Mucosal Immunol2013，6，5： | 1 |
| 20 | Can the soil seed bank contribute to revegetation of the drawdown zone in the Three Gorges Reservoir Region?显示文摘 | Lu Z J Li L F Jiang M X | | Plant Ecology0，209，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员