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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 4 | Keratinolytic protease of Bacillus species isolated from the Amazon basin showing remarkable de-hairing activity显示文摘 | Giongo J L Lucas F S Casarin F | 2007 | Microbiol Biotechnol2007，23，3： | 1 |
| 5 | Influence of the Ion Exchanged Metal (Cu, Co, Ni and Mn) on the Se- lective Catalytic Reduction of NOz Over Mordenite and ZSM-5 显示文摘 | De Lucas A Valverde J L Dorado F | 2005 | Journal of Molecular Catalysis A: Chemical2005，225，1： | 1 |
| 6 | 查看详情显示文摘 | Marco de Lucas M C Fabreguette F Linsavanh M Imhoff L Heintz O Josse-Courty C Mesnier M T Potin V Bourgeois S Sacilotti M | | 0，，： | 1 |
| 7 | Alteration of the bcl-2:bax ratio in the placenta as pregnancy proceeds显示文摘 | De Falco M De Luca L Acanfora F | 2001 | Histochem J2001，33，7： | 1 |
| 8 | Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes显示文摘 | Giuseppe L Luca F Martina M | 2009 | Clin Chem Lab Med2009，47，3： | 1 |
| 9 | Poly ( ethylene-co-vinylacetate) ( EVA) as wax in hibit or of a Brazili an crude oil: oilviscosity, pour point and phase behavior of organic solutions 显示文摘 | Machado A L C Lucas E F Gonzalez G | 2001 | Journal of Petroleum Science and Engineering2001，32，234： | 1 |
| 10 | MicroRNAs: new players in multiple myeloma显示文摘 | Pichiorri F De Luca L Aqeilan RI | 2011 | Front Genet2011，2，： | 1 |
| 11 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 12 | Formation of the structure of chars during devolatilization of pulverized coal and its thermoproperties: A review显示文摘 | Yu J L Lucas J A Wall T F | 2007 | Progress Energy Combust2007，33，2： | 1 |
| 13 | Poly (ethylene-co-vinyl acetate)(EVA)as wax inhibitor of a Brazilian crude oil:Oil viscosity, pour point and phase behavior of organic solutions显示文摘 | MACHADO A L C LUCAS E F GONZáLEZ G | 2001 | Journal of Petroleum Science and Engineering2001，32，2： | 1 |
| 14 | The double yield in the tensile deformation of the polyethylenes 显示文摘 | Lucas J C Failla M D Smith F L | 1995 | Polymer Engineering and Science1995，35，13： | 1 |
| 15 | Alteration of the bcl-2:bax ratio in the placenta as pregnancy proceeds显示文摘 | De Falco M De Luca L Acanfora F | | 0，，07： | 1 |
| 16 | Denitrifieation potential of industrial wastewaters 显示文摘 | de Lucas A Rodriguez L Villasenor J Fernandez F J | 2005 | Water Research2005，39，15： | 1 |
| 17 | Statin-like principles of Bergamot fruit ( Citrus bergamia) : isolation of 3-hydroxymethylglutaryl flavonoid glycosides 显示文摘 | DI DONNA L DE LUCA G MAZZOTFI F | 2009 | J Nat Prod2009，72，7： | 1 |
| 18 | Alteration of the Bcl-2:Bax ratio in the placenta as pregnancy proceeds显示文摘 | De Falco M De Luca L Acanfora F | 2001 | Histochem J2001，33，7： | 1 |
| 19 | Increased prevalence of oxidant stress and inflammation in patients with moder ate to severe chronic kidney disease显示文摘 | Oberg B P Mchmenamin E Lucas F L | | 0，，： | 1 |
| 20 | An overview of transcriptional regulation in response to toxicological insult显示文摘 | Paul J Alice L Luca F | 2013 | Arch Toxicol2013，87，1： | 1 |
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