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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Systemic inflammation and copd: the framing, ham heart study 显示文摘 | Walter R E Wilk J B Larson M G | 2008 | Chest2008，133，1： | 1 |
| 3 | Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study; evidence for susceptibility loci on 1q显示文摘 | Dupuis J Larson M G Vasan R S | 2005 | Atherosclerosis2005，182，2： | 1 |
| 4 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 5 | Time Temperature Relation for Rupture and Creep Stresses显示文摘 | Larson F R Miller J A | 1952 | Trans ASME1952，74，： | 1 |
| 6 | Clonal origin of recurrent meningiomas显示文摘 | von Deimling A Larson J Wellenreuther R | 1999 | Brain Pathol1999，9，4： | 1 |
| 7 | The effect of removing the true dental follicle on premolar eruption in the dog 显示文摘 | LARSON E K CAHILL D R GORSKI J P | 1994 | Arch Oral Biol1994，39，4： | 1 |
| 8 | Changes in rhizosphere populations of selected physiological groups of bacteria related to substitution of specific pairs of chromosomes in spring wheat显示文摘 | Neal J L Larson R I Atkinson T G | 1973 | Plant Soil1973，39，： | 1 |
| 9 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 10 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 11 | Reimmunization after allogeneic bone marrow transplan taton显示文摘 | Somani J Larson R A | | 0，，： | 1 |
| 12 | Granulocyte-macrophage colony stimulating factor-induced immune priming of cyclophosphamide,doxorubicin,vincristine,and prednisone with rituximab chemoimmunotherapy in previously untreated patients with diffuse large B-cell lymphoma and mantle cell lympho显示文摘 | Karmali R Larson M L Wooldridge J E | | 0，，11： | 1 |
| 13 | Selective poisoning and de-activation of acid sites on sulfated zirconia catalysts for n-butane i-somerization显示文摘 | Yaluris G Larson R B Kobe J M | 1996 | Journal of Catalysis1996，158，： | 1 |
| 14 | Triumph over mischance: a role for nuclear medicine in gene therapy显示文摘 | Larson SM Tjuvajev J Biasberg R | 1997 | J Nucl Med1997，38，： | 1 |
| 15 | GPS Measurements of Present-day Convergence Across the Nepal Himalaya显示文摘 | Bilham R Larson K Freymueller J | 1997 | Nature1997，386，： | 1 |
| 16 | Id-1 promotes tumor cell migration in non-small cell lung cancers 显示文摘 | Bhattancharya R Kowalski J Larson AR | 2010 | J Oncol2010，2010，85： | 1 |
| 17 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998，112，2： | 1 |
| 18 | Man;tging motivation: the impact of supervisor feedback on subordinate task interest显示文摘 | HARACKIEWICZ J M LARSON J R | 1986 | Journal of Personali tyand Social Psychology1986，51，3： | 1 |
| 19 | Obesity and systemic oxidative stress:clinical correlates of oxidative stress in the Fram- ingham Study显示文摘 | Keaney J F Jr Larson M G Vasan R S | 2003 | Aeterioscler Thromb Vasc Biol2003，23，3： | 1 |
| 20 | Oxidative polymerization of dissolved phenols by soluble and insoluble inorganic species 显示文摘 | LARSON R A Hufnal J M | 1980 | Limnology and Oceanography1980，25，2： | 1 |
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