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| 1 | Helicobacter pylori and oral pathology:Relationship with the gastric infection显示文摘Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. | Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff | 2014 | World Journal of Gastroenterology2014，20，29： | 21 |
| 2 | ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease显示文摘AIM: To determine the possible association of the ApoB100 (Xba Ⅰ ), ApoE (Hha Ⅰ ) and CYP7A1 (Bsa Ⅰ ) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population. METHODS: The polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by ethnicity, age and sex: patients with GD (n = 101) and stone-free control subjects (n = 101). RESULTS: Allelic frequencies in patients and controls were: 34.16% vs 41.58% (P = 0.124) for X+of ApoB-100; 4.46% vs 5.94% (P = 0.501) for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C of CYP7A1. Differences in genotypic frequencies between the studied groups were not significant (P < 0.05). CONCLUSION: These results demonstrated that no association exists between the studied polymorphisms and cholelithiasis in this high prevalent population. | Sánchez-Cuén Jaime Aguilar-Medina Maribel Arámbula-Meraz Eliakym Romero-Navarro José Granados Julio Sicairos-Medina Laura Ramos-Payán Rosalío | 2010 | World Journal of Gastroenterology2010，16，37： | 14 |
| 3 | Eosinophilic Esophagitis in Adults is Associated with IgG4 and Not Mediated by IgE显示文摘 | Frederic Clayton John C. Fang Gerald J. Gleich Alfredo J. Lucendo Jose M. Olalla Laura A. Vinson Amy Lowichik Xinjian Chen Lyska Emerson Kristen Cox Molly A. O’Gorman Kathryn A. Peterson | 2014 | Gastroenterology2014，，： | 3 |
| 4 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 5 | Skeletal muscle mitochondrial health and spinal cord injury显示文摘Mitochondria are the main source of cellular energy production and are dynamic organelles that undergo biogenesis, remodeling, and degradation. Mitochondrial dysfunction is observed in a number of disease states including acute and chronic central or peripheral nervous system injury by traumatic brain injury, spinal cord injury(SCI), and neurodegenerative disease as well as in metabolic disturbances such as insulin resistance, type Ⅱ diabetes and obesity. Mitochondrial dysfunction is most commonly observed in high energy requiring tissues like the brain and skeletal muscle. In persons with chronic SCI, changes to skeletal muscle may include remarkable atrophy and conversion of muscle fiber type from oxidative to fast glycolytic, combined with increased infiltration of intramuscular adipose tissue. These changes contribute to a proinflammatory environment, glucose intolerance and insulin resistance. The loss of metabolically active muscle combined with inactivity predisposes individuals with SCI to type Ⅱ diabetes and obesity. The contribution of skeletal muscle mitochondrial density and electron transport chain activity to the development of the aforementioned comorbidities following SCI is unclear. A better understanding of the mechanisms involved in skeletal muscle mitochondrial dynamics is imperative to designing and testing effective treatments for this growing population. The current editorial will review ways to study mitochondrial function and the importance of improving skeletal muscle mitochondrial health in clinical populations with a special focus on chronic SCI. | Laura C O'Brien Ashraf S Gorgey | 2016 | World Journal of Orthopedics2016，7，10： | 3 |
| 6 | Serum nutritional markers for prediction of pancreatic exocrine insufficiency in chronic pancreatitis显示文摘 | Bj?rn Lindkvist J. Enrique Domínguez-Mu?oz María Luaces-Regueira Margarita Casti?eiras-Alvari?o Laura Nieto-Garcia Julio Iglesias-Garcia | 2012 | Pancreatology2012，，4： | 2 |
| 7 | Rapid on-site identification of hazardous organic compounds at fire scenes using person-portable gas chromatography-mass spectrometry(GC-MS)—part 2:water sampling and analysis显示文摘Building and factory fires pose a great risk to human and environmental health,due to the release of hazardous by-products of combustion.These hazardous compounds can dissipate into the environment through fire water run-off,and the impact can be immediate or chronic.Current laboratory-based methods do not report hazardous compounds released from a fire scene at the time and location of the event.Reporting of results is often delayed due to the complexities and logistics of laboratory-based sampling and analysis.These delays pose a risk to the health and wellbeing of the environment and exposed community.Recent developments in person-portable instrumentation have the potential to provide rapid analysis of samples in the field.A portable gas chromatograph-mass spectrometer(GC-MS)was evaluated for the on-site analysis of water samples for the identification of hazardous organic compounds at fire scenes.The portable GC-MS was capable of detecting and identifying a range of volatile and semi-volatile organic compounds in fire water run-off,and can be used in conjunction with conventional laboratory analysis methods for a comprehensive understanding of hazardous organics released at fire scenes.Deployment of this portable instrumentation provides first responders with a rapid,on-site screening tool to appropriately manage the run-off water from firefighting activities.This ensures that environmental and human health is proactively protected. | Rylee Lam Chris Lennard Graham Kingsland Paul Johnstone Andrew Symons Laura Wythes Jeremy Fewtrell David O’Brien Val Spikmans | 2020 | Forensic Sciences Research2020，5，2： | 2 |
| 8 | Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease显示文摘 | Carlos Jose Pirola Tomas Fernández Gianotti Adriana Laura Burgue?o Manuel Rey-Funes Cesar Fabian Loidl Pablo Mallardi Julio San Martino Gustavo Osvaldo Casta?o S Sookoian | 2013 | Gut2013，，9： | 2 |
| 9 | Lateral Internal Sphincterotomy is Superior to Topical Nitroglycerin for Healing Chronic Anal Fissure and does not Compromise Long-Term Fecal Continence: Six-Year Follow-Up of a Multicenter, Randomized, Controlled Trial显示文摘 | Carl J. Brown M.D. Daniel Dubreuil M.D. Laura Santoro B.Sc. Maria Liu B.Sc. Brenda I. O'Connor B.ScN. Robin S. McLeod M.D | 2007 | Diseases of the Colon & Rectum2007，，4： | 2 |
| 10 | A graph descrip- tion and analysis framework of liver vascular system显示文摘 | CHEN Y DRECHSLER K LAURA C O | 2011 | Journal of Computational Information Systems2011，7，6： | 1 |
| 11 | Pathways of lymphatic spread in male urogenital pelvic malignancies显示文摘 | Blanca Pa?o Laura Bu?esch Judit Mestrest | | 0，，： | 1 |
| 12 | Glycosylation of individual whey proteins by Maillard reaction using dextran of different molecular mass显示文摘 | Laura Jiménez-Casta?o Mar Villamiel Rosina López- Fandi?o | 2007 | Food Hydrocolloids2007，21，3： | 1 |
| 13 | A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer显示文摘 | Covadonga Huidobro Rocío G. Urdinguio Ramón María Rodríguez Cristina Mangas Vincenzo Calvanese Pablo Martínez-Camblor Cecilia Ferrero Adolfo Parra-Blanco Luis Rodrigo álvaro J. Obaya Laura Suárez-Fernández Aurora Astudillo Henar Hernando Esteban Ballestar | 2011 | European Journal of Cancer2011，，14： | 1 |
| 14 | Immunoprecipitation of native chromatin : nChIP显示文摘 | Laura P Neill O Turner B M | 2003 | Methods2003，31，： | 1 |
| 15 | Growth, fruiting and lignocel- lulolytic enzyme production by the edible mushroom Grifolafron-dosa (maitake) 显示文摘 | Sandra M Carlos E O Laura L | 2012 | World J Microbiol Biotechnol2012，28，4： | 1 |
| 16 | Gene expression and protein localization of TLR-1, -2, -4 and -6 in amniochorion membranes of pregnancies complicated by histologic chorioamnionitis显示文摘 | Natália P. Mo?o Laura F. Martin Ana Carolina Pereira Jossimara Polettini José C. Pera?oli Kunie I.R. Coelho Márcia G. da Silva | 2013 | European Journal of Obstetrics and Gynecology2013，，： | 1 |
| 17 | The chemistry of suspended particulate material in a highly contarninated embayment of port Jackson(Australia) under quiescent,high-wind and heavy-rainfall conditions显示文摘 | Gavin B Laura O H | | 0，，03： | 1 |
| 18 | Return to launch site trajectory options for a reusable booster without a secondary propulsion system 显示文摘 | Laura A L John R O | 2002 | Journal of Spacecraft and Rockets2002，39，3： | 1 |
| 19 | Immunoprecipitation of native ehromatin: nCHIP 显示文摘 | Laura P Neill O Turner B M | 2003 | Methods2003，31，： | 1 |
| 20 | Tumour size as a predictor of axillary node metastases in patients with breast cancer显示文摘 | Laura S Coombs NJ Ung O | 2006 | ANZ J Surg2006，76，11： | 1 |
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