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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 3 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 4 | Investigation of deformability, viscosity, and aggregation of mPEG-modified erythrocytes显示文摘 | Leach JK Hinman A O'Rear EA | 2002 | Biomed Sci Instrum2002，38，： | 1 |
| 5 | Developmental regulation of respiratory activity in pea leaves 显示文摘 | Lennon A M Pratt J Leach G e al | 1995 | Plant Physiol1995，107，： | 1 |
| 6 | Modelling high level system design and unit commitment for a microgrid 显示文摘 | HAWKES A D LEACH M A | 2009 | Applied Energy2009，86，17： | 1 |
| 7 | Gabapentin and cognition: a double blind, dose ranging, placebo controlled study in refractory epilepsy 显示文摘 | LEACH JP GIRVAN J PAUL A | 1997 | J Neurol Neurosurg Psychiatry1997，62，4： | 1 |
| 8 | Nucleotide sequence,organization and nature of protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus显示文摘 | ARMSTRONG G A ALBERTI M LEACH F | 1989 | Mol Gen Genet1989，216，： | 1 |
| 9 | Mee F B:High altitude dives in the Nepali Himalaya显示文摘 | Leach J McLean A | 1994 | Undersea Hyperb Med1994，21，4： | 1 |
| 10 | Anger and guilt about ingroup advantage explain the willingness for political aetion显示文摘 | Leach C W Iyer A Pedersen A | 2006 | Person- ality and Social Psychology Bulletin2006，32，9： | 1 |
| 11 | The impact of research education on student nurse attitude, skill and uptake of evidence-based practice: a descriptivelongitudinalsurvey显示文摘 | Leach M J Hofmeyer A Bobridge A | 2016 | JClinNurs2016，25，12： | 1 |
| 12 | In vitro Cytotoxicity of Australian Tea Tree Oil Using Human Cell Lines显示文摘 | HAYES A J LEACH D N MARKHAM J L | 1997 | Journal Essential Oil Research1997，9，5： | 1 |
| 13 | The laryngeal mask,an overview显示文摘 | LEACH A B ALEXANDER C A | 1991 | Eur J Aneasthsiol1991，4，： | 1 |
| 14 | The Kelian disseminated gold deposit,East Kalimantan,Indonesia显示文摘 | Van Leeuwen T M Leach T Hawke A A | 1990 | Journal of Geochemical Exploration1990，50，： | 1 |
| 15 | A repetitive DNA sequence common to the different B chromosomes of the genus B rachycome显示文摘 | HOUBEN A Leach C R Verlin D | 1997 | Chromosoma1997，106，： | 1 |
| 16 | Conditions for Photovoltaics Development in the UK: The Rrole of Policy and Technical Developments 显示文摘 | Candelise C Gross R & Leach M A | 2010 | Power&En- ergy2010，224，2： | 1 |
| 17 | Modelling high level system design and unit commitment for a microgrid显示文摘 | HAWKES A D LEACH M A | | 0，，7： | 1 |
| 18 | Effects of high plant populations on the growth and yield of winter oilseed rape(Brassica napus)显示文摘 | LEACH J E STEVENSON H J RAINBOW A J | 1999 | Journal of Agricultural Science1999，132，2： | 1 |
| 19 | Automated seizure detection using a self-organizing neural network显示文摘 | GABOR A J LEACH R R DOWLA F U | 1996 | Electroen- cephalogr Clin Neurophysiol1996，99，3： | 1 |
| 20 | Coronary bypass graft fate and patient outcome:angiographic follow -up of 5065 grafts related survival and reoperation in 1388 patients during 25 years 显示文摘 | Fitzgibbon G M Kafka H P Leach A J | 1996 | J Am Coil Cardiol1996，28，： | 1 |
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