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| 1 | Update on hepatocellular carcinoma: Pathologists' review显示文摘Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC.Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC:Steatohepatitic, clear cell, fibrolamellar and scirrhous-and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed. | Tony El Jabbour Stephen M Lagana Hwajeong Lee | 2019 | World Journal of Gastroenterology2019，25，14： | 25 |
| 2 | Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 Over Expression in Transgenic Mice Suppresses Intestinal Neoplasia显示文摘 | Seung Joon Baek Ryuji Okazaki Seong-Ho Lee Jeanelle Martinez Jong-Sik Kim Kiyoshi Yamaguchi Yuji Mishina David W. Martin Ahmed Shoieb Michael F. Mcentee Thomas E. Eling | 2006 | Gastroenterology2006，，5： | 2 |
| 3 | Characterizalion of a novel and potent collageOn antagonist, caffeic acid phenethyl ester, in human platelets: In vitro and in vivo studies显示文摘 | GeorgeHsiao JieJ Lee KuangH Lin el al | 2007 | Cardiovascular Research2007，75，： | 1 |
| 4 | Solitary pulmonary nodules: dynamic enhanced multi-detector row CT study and compari son with vascular endothelial growth factor and microvessel density显示文摘 | Chin A Yi Kyung Soo Lee Eun A Kim el al | 2004 | Radiology2004，233，： | 1 |
| 5 | Measurement of the Elastic Properties and Intrinsic Strength of Monolayer Graphene 显示文摘 | Lee C G Wei X D Kysar J W el al | 2008 | Science2008，321，5887： | 1 |
| 6 | Dihydroartemisinin enhances radio- sensitivity of human glioma cells in vitro 显示文摘 | Kim S J Kim MS Lee JW el al | 2006 | J Cancer Rcs Clin Oneol2006，132，2： | 1 |
| 7 | Exosomes and mierovesicles: extracellular vesicles for genetic information transfer and gene therapy显示文摘 | Lee Y El Andaloussi S Wood M J | 2012 | Hum Mol Genet2012，21，1： | 1 |
| 8 | IgA nephropathy : morphologle predictors of progressive renal disease显示文摘 | Lee SM Rao VM Franklin WA el al | 1982 | Hum Pathol1982，13，： | 1 |
| 9 | The use of nitrite in meat显示文摘 | Cassens R G /to T Lee M el al | 1978 | Bio- science1978，28，10： | 1 |
| 10 | Pelvic arteriove- nous malformation: gadolinium-enhanced three-dimensional MR angiography findings显示文摘 | Diaz Candamio M J Lee V S Rofsky N M el al | 2000 | Eur Radiol2000，10，12： | 1 |
| 11 | Supine LBNP exer- cise maintains exercise eapaeity in male twins during 30d hed rest显示文摘 | Lee SM Schneider SM Boda WL el al | 2007 | Med Sci Sports Exert2007，39，8： | 1 |
| 12 | Static resistivity image of a cubic saline phantom in magnetic resonance electrical impedance tomography (MREIT) 显示文摘 | Lee BI Oh SH Woo El | 2003 | Physiol Mess2003，24，2： | 1 |
| 13 | Petri-net based formulation and algorithm for short-term scheduling of batch plants显示文摘 | Ghaeli M Bahri P A Lee P et el | 2005 | Computers & Chemical Engineering2005，29，2： | 1 |
| 14 | Improving the quality of the surgical mm'bidity and mortality conference: a prospective inter- vention study显示文摘 | Mitchell EL Lee DY Arora S | 2013 | Acad Med2013，88，6： | 1 |
| 15 | Comparision of muhifidus muscle atrophy and trunk extension muscle strength:pereuta-neous versus open pedide serew fixation显示文摘 | Kim DY Lee SH Chung SK el al | 2005 | Spine2005，1，： | 1 |
| 16 | Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo显示文摘 | Hackett NR El Sawy T Lee LY Silva I O′Leary J Rosengart TK | 2000 | Mol Ther2000，2，6： | 1 |
| 17 | EGFR mutations in hmg cancer: Correlation with clinical response to gefitinib therapy 显示文摘 | Paez JG Janne PA Lee JC Traey S Greulich H Gabriel S el al | 2004 | Science2004，304，4： | 1 |
| 18 | Benign vs malignant pancreatic lesions: Molecular insights to an ongoing debate显示文摘Several benign conditions such as chronic pancreatitis, autoimmune pancreatitis,and paraduodenal pancreatitis can present as mass lesions and may mimicpancreatic ductal adenocarcinoma (PDAC) clinically and radiologically. Thoroughhistologic examination with attention to certain morphologic features can assist indeciphering neoplastic from reactive, however small biopsies often remain achallenge. Variable histologic patterns in conventional PDAC may also confoundthe diagnosis of PDAC. Uncommon subtypes of pancreatic carcinoma such asadenosquamous and squamous cell carcinoma, colloid carcinoma, medullarycarcinoma, hepatoid carcinoma and signet ring cell carcinoma necessitateexcluding metastasis from other sites prior to rendering the diagnosis ofpancreatic carcinoma. The use of immunohistochemical staining and molecularmarkers can aid in separating benign from malignant and PDAC from metastasis.PDAC expresses a few non-specific epithelial and mucin immunomarkers such asCK7, CK19, MUC1, MUC4 and MUC5AC. However, the only immunohistochemicalmarker that is specific for PDAC in the right clinical context is SMAD4.Loss of SMAD4 within atypical glands and ducts supports the diagnosis of PDACin a limited sample. Unfortunately, this finding is seen only in 50% of PDACcases. The identification of certain mutations can help support a diagnosis ofPDAC when benign conditions are in the differential. At the molecular level,KRAS oncogene mutations are seen in approximately 93% of PDACs. Subsequentneoplastic progression is driven by additional mutations of tumor suppressorgenes, such as CDKN2A, TP53, and SMAD4. Molecular markers can also providean insight to the prognosis. For instance, the loss of SMAD4 is associated with apoor outcome whereas mutations in MLL, MLL2, MLL3, and ARID1A are associatedwith improved survival. | Mahmoud Aldyab Tony El Jabbour Megan Parilla Hwajeong Lee | 2021 | World Journal of Gastrointestinal Surgery2021，13，5： | 1 |
| 19 | Effect of environmental factors on myeelial growth of Peronophythora litchi显示文摘 | Chen L C Lai S C Lee C C at el | 1998 | Plant Pathology Bulletin1998，，7： | 1 |
| 20 | IK1 channel activ-ity contributes to cisplatin sensitivity of human epidermoidcancer cells显示文摘 | Lee EL Hasegawa Y Shimizu T | 2008 | Am J Physiol cell Phusiol2008，10，： | 1 |
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