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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | 20世纪70年代以来松嫩平原乌裕尔河中下游流域的湿地演变显示文摘基于LandsatMSS和TM影像,在GIS技术支持下分析了20世纪70年代中期以来松嫩平原乌裕尔河中下游流域湿地的时空变化。研究表明1976—2000年间研究区湿地变化十分显著,沼泽湿地净减少7.47×104hm2,分别有约5.58×104hm2和3.40×104hm2的沼泽湿地被开垦为旱地和水田。湿地水资源短缺,约8097.70hm2沼泽变为干草地,1039.58hm2退化成为盐碱地。因洪水淹没,草地沼泽化面积达到2.74×104hm2。耕地总面积净增加12.97×104hm2,8.10×104hm2的旱地转变为水田。草地面积锐减16.93×104hm2,其中44.4%被开发为耕地,约22.3%变为盐碱地,中覆盖度草地退化面积达到2.26×104hm2,但低覆盖度草地退化的速度快。湿地景观斑块数量减少,平均规模缩小,景观更破碎。天然湿地的萎缩和退化与区域气候暖干化趋势和高强度人类活动密切相关。 | 黄方 张树文 Jan de Leeuw 张养贞 | 2006 | 自然资源学报2006，21，6： | 15 |
| 3 | 健康城市——发展历程、建设方法和评估机制显示文摘健康城市的研究、监督和评价,必须建立在科学的方法和方法论基础上。调查既往导致健康不公平的因素,收集社会人口数据及编辑相关资料,总结市政当局直接或间接处理公平性问题的政策及程序,选择上述政策可产生影响和不能影响的政策进行比较,评价影响参与健康城市项目的各个因素,评价主观与客观的效益,寻求促进健康公平性的措施,这就是健康城市的评价与建设要回答的问题。 | Evelyne de Leeuw 郑英杰 | 2006 | 医学与哲学(A)2006，27，1： | 13 |
| 4 | 利用多时相Landsat影像生成白洋淀湖底DEM的研究显示文摘该文使用多时相Landsat影像,以白洋淀地区为例,阐述基于中等分辨率的可见光—近红外遥感影像生成具有较高精度数字高程模型的非常规方法。对覆盖同一研究区的不同时相影像分别进行淹没区与非淹没区的分类,提取不同水位高度时的水域边界,并以此为相应水位高度的等高线,对获得的等高线进行插值生成数字高程模型(DEM)。这种由一系列遥感影像提取的水域图生成数字高程模型的方法适用于人为干预较少、地形相对简单的湿地或季节性湖泊,可以弥补该类地区数字高程信息不足或精度不够的缺陷。 | 沈欣 欧阳志云 Jande LEEUW | 2005 | 地理与地理信息科学2005，21，2： | 9 |
| 5 | 发展健康城市项目的20个步骤显示文摘 | 王书梅 Evelyne de Leeuw | 2002 | 中国健康教育2002，18，1： | 5 |
| 6 | Towards Quantitatively Understanding the Complexity of Social-Ecological Systems——From Connection to Consilience显示文摘The complexity of social-ecological systems(SES) is rooted in the outcomes of node activities connected by network topology. Thus far, in network dynamics research, the connectivity degree(CND), indicating how many nodes are connected to a given node, has been the dominant concept. However, connectivity focuses only on network topology, neglecting the crucial relation to node activities, and thereby leaving system outcomes largely unexplained. Inspired by the phenomenon of ‘‘consensus of wills and coordination of activities' ' often observed in disaster risk management, we propose a new concept of network characteristic, the consilience degree(CSD),aiming to measure the way in which network topology and node activities together contribute to system outcomes. The CSD captures the fact that nodes may assume different states that make their activities more or less compatible.Connecting two nodes with in/compatible states will lead to outcomes that are un/desirable from the perspective of the SES in question. We mathematically prove that the CSD is a generalized CND, and the CND is a special case of CSD. As a general, fundamental concept, the CSD can facilitate the development of a new framework of network properties, models, and theories that allows us to understand patterns of network behavior that cannot be explained in terms of connectivity alone. We further demonstrate that a co-evolutionary mechanism can naturally improve the CSD. Given the generality of co-evolution in SES, we argue that the CSD is an inherent attribute rather than an artificial concept, which underpins the fundamental importance of the CSD to the study of SES. | Xiao-Bing Hu Peijun Shi Ming Wang Tao Ye Mark S.Leeson Sander E.van der Leeuw Jianguo Wu Ortwin Renn Carlo Jaeger | 2017 | International Journal of Disaster Risk Science2017，8，4： | 4 |
| 7 | Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis显示文摘Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal movement.Degeneration of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal aging.Unfortunately,the body does not fully repair itself from this type of degeneration,resulting in impaired movement.Microfracture,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage sites.Mesenchymal stem cells(MSC)have also been used as cell therapy to repair degenerated cartilage.However,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the cartilage.The repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline cartilage.One of the reasons for this is inefficient chondrogenesis by endogenous and exogenous MSC.Drugs that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic outcomes.The recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell type.Here we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis. | Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright Jane Peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，12： | 3 |
| 8 | Fertility results using bovine semen cryopreserved with extenders based on egg yolk and soy bean extract显示文摘 | A.M. van Wagtendonk-de Leeuw R.M. Haring L.M.T.E. Kaal-Lansbergen J.H.G. den Daas | 2000 | Theriogenology2000，，1： | 2 |
| 9 | The Silk Road agenda of the Pan-Eurasian Experiment (PEEX) program显示文摘The Silk Road Economic Belt and the 21st-Century Maritime Silk Road(B&R)aims at facilitating the twenty-first Century economic development of China.However,climate change,air quality and related feedbacks are affecting the successful development of the environment and societies in the B&R geographical domain.The most urgent risks related to the atmospheric system,to the land system and to hydrospheric and cryospheric processes are changing climate-air quality interactions,air pollution,changing monsoon dynamics,land degradation,and the melting of Tibetan Plateau glaciers.A framework is needed in which a science and technology-based approach has the critical mass and expertise to identify the main steps toward solutions and is capable to implement this roadmap.The Pan-Eurasian Experiment(PEEX)program,initiated in 2012,aims to resolve science,technology and sustainability questions in the Northern Eurasian region.PEEX is now identifying its science agenda for the B&R region.One fundamental element of the PEEX research agenda is the availability of comprehensive ground-based observations together with Earth observation data.PEEX complements the recently launched international scientific program called Digital Belt and Road(DBAR).PEEX has expertise to coordinate the ground-based observations and initiate new flagship stations,while DBAR provides a big data platform on Earth observation from China and countries along the Belt and Road region.The DBAR and PEEX have joint interests and synergy expertise on monitoring on ecological environment,urbanization,cultural heritages,coastal zones,and arctic cold regions supporting the sustainable development of the Belt and Road region.In this paper we identify the research themes of the PEEX related Silk Road agenda relevant to China and give an overview of the methodological requirements and present the infrastructure requirements needed to carry out large scale research program. | Hanna K.Lappalainen Markku Kulmala Joni Kujansuu Tuukka Petaja Alexander Mahura Gerrit de Leeuw Sergej Zilitinkevich Merli Juustila Veli-Matti Kerminen Bob Bornstein Zhang Jiahua Xue Yong Qiu Yubao Liang Dong Liu Jie Guo Huadong | 2018 | Big Earth Data2018，2，1： | 2 |
| 10 | 内皮细胞活化与高血压患者的认知功能有关显示文摘高血压与认知功能障碍和痴呆的发生有关,可能是因为高血压是引发脑损伤的一个重要危险因素,脑损伤是脑小血管病的一种表现。已发现内皮细胞活化和炎症在脑小血管病的发病机制中发挥重要作用。该研究调查以几种血管标志物为基础的内皮细胞活化或炎症的综合积分是否与原发性高血压患者3年后的认知功能有关。 | Uiterwijk R Huijts M Staals J Rouhl RP De Leeuw PW Kroon AA Van Oostenbrugge RJ 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 11 | Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors显示文摘 | Looijenga LH de Leeuw H van Oorschot M | 2003 | Cancer Res2003，63，22： | 1 |
| 12 | Rescue of Newcastle disease virus from cloned cDNA:Evidence that cleavability of the Fusion protein is a major determinant for virulence显示文摘 | Peeters B P de Leeuw O S Koch G | 1999 | J Virol1999，73，6： | 1 |
| 13 | Restricted utility of the pristane/phytane ratio as a palaeoenvironmental indicator显示文摘 | ten Haven H L de Leeuw J W Rullkotter J | 1987 | Nature1987，330，6149： | 1 |
| 14 | Solution-processed ambipolar organic field-effect transistors and inverters显示文摘 | Meijer E J De Leeuw D M Setayesh S | | 0，，10： | 1 |
| 15 | The absence of long-chain alkyl diols and alkyl keto-1-ols in cultures of the cyanobacteriumAphanizomenon flos-aquae显示文摘 | de Leeuw J W Rijpstra W I C Mur L R | 1992 | Organic Geochemistry1992，18，4： | 1 |
| 16 | The occurrence of polyeylie sesqui-, tri-, and oligoterpe- noids derived from a resinous polymeric eadinene in crude oils from southeast Asia 显示文摘 | Van Aarssen B G K Hessels J K C Abbink O A De Leeuw J W | 1992 | Geoehim Cosmoehim Aeta1992，56，3： | 1 |
| 17 | The association of smoking status with sleep disturbance, psychological functioning, and pain severity in patients with temporomandibular disorders 显示文摘 | Sde Leeuw R Eisenlohr-Moul T Bertrand P | 2013 | J Orofac Pain2013，27，1： | 1 |
| 18 | Brain imaging in patients with diabetes: A systematic review显示文摘 | van Harten B de Leeuw FE Weinstein HC | 2006 | Diabetes Care2006，29，11： | 1 |
| 19 | The prognostic value Of FoxP3 + tumor - infiltrating lymphocytes in cancer : a critical review of the literature显示文摘 | de Leeuw ILl Kost SE Kakal JA | 2012 | Clin Cancer Res2012，18，11： | 1 |
| 20 | Cytogenetics of a renal adenocarcinoma in a 2 - year - old child 显示文摘 | de Jong B Molenaar IM Leeuw JA | 1986 | Cancer genetics and eytogenetics1986，21，2： | 1 |
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