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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 3 | Holmium laser versus conventional transurethral resection of the bladder tumor显示文摘 | TENG Jing-fei WANG Kai YIN Lei QU Fa-jun ZHANG Dong-xu CUI Xin-gang XU Dan-feng | 2013 | Chinese Medical Journal2013，，9： | 32 |
| 4 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 5 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 6 | Nature:骨髓微环境发生突变可导致造血干细胞异常显示文摘白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病,来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身。让细胞自身生长更快。相比之下,努南综合征小鼠模型上可以观察到间接的邻近细胞效应,努南综合征是一种能够增加白血病患病风险的遗传紊乱。 | Lei Dong, Wen-Mei Yu, Hong Zheng, Melinda Pauly, Muxiang Zhou Cheng-Kui Qu Mignon L. Loh Silvia T. Bunting Gang Huang Hal E. Broxmeyer David T. Scadden | 2016 | 现代生物医学进展2016，16，35： | 18 |
| 7 | Fetal central nervous system anomalies: comparison of magnetic resonance imaging and ultrasonography for diagnosis显示文摘胎儿的中央神经系统(CNS ) 的背景评估发育不全 byultrasonography (美国) 经常被限制,但是磁性的回声成像(MRI ) 有它的自己的优点并且在显示怀疑的胎儿的异例正在获得流行。这研究的目的是在检测胎儿的 CNS 发育不全探索 MRI 的价值。方法 34 个女人(从 22 ~ 35 年年老,一般水准 27 年) 与复杂怀孕(16- 39 星期怀孕期,一般水准 30 星期) 在 ultrasonography 以后在 24 个小时以内与 1.5 T 超导的先生单位被检验。Half-Fourier 获得单个射击的涡轮纺纱回响(匆忙) T_2-weightedimaging (T_2WI ) 顺序在所有病人,和快低角度射击(闪光) 被执行 T_1 加权的成像(T_1WI ) 顺序在他们中的七个顺序被使用。结果的比较在 MRI 和美国调查结果以及尸体或出生后的后续 MRIfindings 之间被做。胎儿的回转, sulcus,语料库 callosum,丘脑,小脑,大脑茎,和针的绳索比在 T_1 加权的先生图象上在 T_2 加权的先生图象上更清楚地被显示出的结果。MRIcorrected 在 10 种情况中的美国的诊断(10/34, 29.41%) 并且诊断仅仅在 1case 被错过(1/34, 2.94%) 。结论 MRI 在检测胎儿的 CNS 异例有优点到美国并且是对在复杂怀孕的美国的补充。 | WANG Guang-bin SHAN Rui-qin MA Yu-xiang SHI Hao CHEN Li-guang LIU Wen QIU Xiu-ling WEI Yu-long GUO Li QU Lei LI Hui-hua | 2006 | Chinese Medical Journal2006，，15： | 18 |
| 8 | Composites of small Ag clusters confined in the channels of well-ordered mesoporous anatase TiO2 and their excellent solar-light-driven photocatalytic performance显示文摘 | Wei Zhou Ting Li Jianqiang Wang Yang Qu Kai Pan Ying Xie Guohui Tian Lei Wang Zhiyu Ren Baojiang Jiang Honggang Fu | 2014 | Nano Research2014，7，5： | 17 |
| 9 | Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells and Schwann cells显示文摘背景最重要的目的在受伤针的绳索移植研究是为 axonal 生长提供有利环境。而且,新接枝的持续发现正在提供新潜在地有趣移植候选人。我们的目的是观察神经干细胞(NSC ) 的合作移植的词法、功能的修理效果, Schwann 装壁板圩(SC ) 并且 poly rats.Methods 的针的绳索损害上的 lactide-co-glycolide 酸(PLGA ) PLGA 的脚手架被制作。NSC 和 SC 是有教养的,与用 5-bromodeoxyuridine 标记的 NSC,并且 NSC/PLGA 或 NSC+SCs/PLGA 的建筑群被构造。36 只 Wistar 老鼠随机被划分成三个组:组织 A (PLGA 的移植) ,组织 B (NSC/PLGA 的移植) 并且组织 C (NSC+SCs/PLGA 的移植) 。正确 hemicord 的 3 公里长度在所有老鼠在显微镜下面被移开。PLGA 或 PLGA-celIs 的建筑群被植入进损害地点。Basso-Beattie-Bresnahan (BBB ) 运动分数,马达和更低的手足潜在的唤起的 somatosensory 被检验听说康复感觉并且在在损害以后的 4 个星期, 8 个星期, 12 个星期和 24 个星期的马达功能。所有恢复针的绳索损害( SCI )纸巾被观察与他染色, immunohistochemistry ,和 transelectronmicroscopy 到在 4 个星期识别移植房间和神经纤维的新生的幸存,迁居和区别, 8 个星期,在到在损害以后的 24 个星期的从 4 个星期的 injury.Results ( 1 )以后的 12 个星期和 24 个星期,移植房间的组的 BBB 运动分数比 non-cell-transplanted 组的那些好,特别组 C ( P 0.05 )。somatosensory 的振幅唤起了潜力(9 月) ,唤起马达的潜力(MEP ) 在组 B 和 C 在损害以后被改进,但是在 4 个星期的 9 月和 MEP 的振幅在损害以后在 12 个星期和 24 个星期是比那低的。与组 B 相比,在组 C 的 9 月和 MEP 的振幅被改进。9 月和 MEP 的振幅没在组 A 在损害以后被改进。(2 ) 他染色表明支架的体积减少了,在支架的房间的数字增加了。成长得最新的 capillaries 能也被看见。染色的 Immunohistochemistry 证明移植 NSC 能幸存并且移居直到 24 个星期和他们能区分进神经原和 oligodendrocytes。改革轴突与 transelectronmicroscopy 在支架房间建筑群被观察。上述表明在在损害,和他们能区分进各种各样的神经房间以后,移植 NSC 能在老鼠的针的绳索熬过并且移居直到 24 个星期的组 C.Conclusions 是更广泛的。cells/PLGA 的合作移植能支持受伤针的绳索的功能的恢复。共同移植的效果 NSC+SCs/PLGA 比独自移植 NSC/PLGA 好。 | CHEN Gang HU Yan-rong WAN Hong XIA Lei LI Jun-hua YANG Fei QU Xue WANG Shen-guo WANG Zhong-cheng | 2010 | Chinese Medical Journal2010，，17： | 16 |
| 10 | Discovery and preliminary study of the high tungsten and lithium contents in the Dazhuyuan bauxite deposit, Guizhou, China显示文摘Bauxite in China remains an urgently needed resource largely dependent on imports. Based on the study of the newly-discovered Dazhuyuan bauxite deposit in northeastern Guizhou, we have found new enrichment of tungsten and lithium in bauxite, with the highest WO 3 content up to 0.33% and the highest Li 2 O content up to 0.58%. The present paper reports the initial result, and the spatial distribution feature of W and Li in the ore body (with Li enriched mostly in the north part of the west limb of the Liyuan syncline, whereas W enriched mostly in the central part of the east limb). The results suggest that it is necessary to delineate lithium and tungsten ore body independently, discuss the feasibility of its industrial utilization, and point out the new direction of synthetic appraisal for such kinds of traditional mineral resources, in order to forecast and assess bauxite resources in the region. | WANG DengHong LI PeiGang QU WenJun YIN LiJuan ZHAO Zhi LEI ZhiYuan WEN ShenFu | 2013 | Science China Earth Sciences2013，56，1： | 16 |
| 11 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 12 | The revised Atlanta criteria 2012 altered the classification,severity assessment and management of acute pancreatitis显示文摘BACKGROUND:The Atlanta criteria for acute pancreatitis(AP) has been revised recently.This study was to evaluate its practical value in classification of AP,the severity assessment and management.METHODS:The clinical features,severity classification,outcome and risk factors for mortality of 3212 AP patients who had been admitted in Ruijin Hospital from 2004 to 2011 were analyzed based on the revised Atlanta criteria(RAC) and the original Atlanta criteria(OAC).RESULTS:Compared to the OAC group,the incidence of severe acute pancreatitis(SAP) was decreased by approximately one half(13.9% vs 28.2%) in the RAC group.The RAC presented a lower sensitivity but higher specificity,and its predictive value for severity and poor outcome was higher than those of the OAC.The proportion of SAP diagnosis and ICU admission in the early phase in the RAC group was significantly lower than that in the OAC group(P<0.05).Based on the RAC,the risk factors for death among SAP patients were older age,high CT severity index(CTSI),renal failure,cardiovascular failure,acute necrotic collection and walled-off necrosis.Compared to the OAC,the acute physiology and chronic health evaluation II(APACHE II) score,Ranson score,idiopathic etiology,respiratory failure and laparotomy debridement were not risk factors of death in contrast to walled-off necrosis.Interestingly,hypertriglyceridemia-related SAP had good outcomes in both groups.CONCLUSIONS:The RAC showed a higher predictive value for severity and poorer outcome than the OAC.However,the RAC resulted in fewer ICU admissions in the early phase due to its lower sensitivity for diagnosis of SAP.Among SAP cases,older age,high CTSI,renal and cardiovascular failure,complications of acute necrotic collection and walled-off necrosis were independent risk factors for mortality. | Jie Huang Hong-Ping Qu Yun-Feng Zheng Xu-Wei Song Lei Li Zhi-Wei Xu En-Qiang Mao Er-Zhen Chen | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 15 |
| 13 | Clinical analysis of intracranial germinoma's craniospinal irradiation using helical tomotherapy显示文摘Objective: To evaluate the short-term clinical outcomes of intracranial germinoma patients treated with craniospinal irradiation(CSI) using helical tomotherapy(HT) system in our center. Methods: Twenty-three patients who were treated with CSI in our center from January 2008 to July 2012 were collected, with an average age of 20. All of the patients' CSI used the HT system. The total doses were 27-36 Gy/15-20 F(1.5-2 Gy per fraction), and total local doses were 46-60 Gy/30-50 F(5 fractions per week). All female patients for CSI were treated with left-right parallel-opposed field irradiation to protect their ovarian functions. Median follow-up time was 30.9 months(range, 5-67 months). The SPSS19.0 software was used, and the overall survival(OS) was calculated using the Kaplan-Meier method.Results: Among 17 patients with assessable tumors, 9 cases(52.9%) were CR, 7 cases(41.2%) were PR, and 1 case(5.9%) was SD. Hematological toxicity was the severest side-effect occurred in the procedure of CSI. The level 1-4 acute leukopenia were 8.7%, 30.4%, 34.8% and 21.7% and the level 1-4 acute thrombopenia were 8.7%, 30.4%, 21.7% and 8.7%, respectively.Conclusions: For primary intracranial germinomas, HT can be used to implement CSI for simplifying radiotherapy procedures, improving radiotherapy accuracy, enhancing protection of peripheral organs at risk(ORA) and guaranteeing therapeutic effects. With the acceptable acute and long-term toxicity, CSI using HT in intracranial germinoma patients can be a safe and alternative mode. | Baolin Qu Lei Du Yurong Huang Wei Yu Boning Cai Shouping Xu Lin Ma | 2014 | Chinese Journal of Cancer Research2014，26，3： | 14 |
| 14 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 15 | Effects of viral infection and microbial diversity on patients with sepsis:A retrospective study based on metagenomic next-generation sequencing显示文摘BACKGROUND: The study aims to investigate the performance of a metagenomic next-generationsequencing (NGS)-based diagnostic technique for the identifi cation of potential bacterial and viral infectionsand eff ects of concomitant viral infection on the survival rate of intensive care unit (ICU) sepsis patients.METHODS: A total of 74 ICU patients with sepsis who were admitted to our institution from February1, 2018 to June 30, 2019 were enrolled. Separate blood samples were collected from patients for bloodcultures and metagenomic NGS when the patients’ body temperature was higher than 38 °C. Patients’demographic data, including gender, age, ICU duration, ICU scores, and laboratory results, were recorded.The correlations between pathogen types and sepsis severity and survival rate were evaluated.RESULTS: NGS produced higher positive results (105 of 118;88.98%) than blood cultures(18 of 118;15.25%) over the whole study period. Concomitant viral infection correlated closelywith sepsis severity and had the negative effect on the survival of patients with sepsis. However,correlation analysis indicated that the bacterial variety did not correlate with the severity of sepsis.CONCLUSIONS: Concurrent viral load correlates closely with the severity of sepsis and thesurvival rate of the ICU sepsis patients. This suggests that prophylactic administration of antiviraldrugs combined with antibiotics may be benefi cial to ICU sepsis patients. | Li-wei Duan Jin-long Qu Jian Wan Yong-hua Xu Yi Shan Li-xue Wu Jin-hao Zheng Wei-wei Jiang Qi-tong Chen Yan Zhu Jian Zhou Wen-bo Yu Lei Pei Xi Song Wen-fang Li Zhao-fen Lin | 2021 | World Journal of Emergency Medicine2021，12，1： | 14 |
| 16 | Pyogenic liver abscesses associated with nonmetastatic colorectal cancers: An increasing problem in Eastern Asia显示文摘AIM: To elaborate the clinicopathologic features of colorectal cancer-related pyogenic liver abscess (PLA). METHODS: Reported cases of colorectal cancer-related PLAs were collected from the literature published up to October 2011 and evaluated for their clinicopathologic features. Data of collected cases included demographics, clinical presentation, microbial findings and treatment. Categorical variables were compared by 2 analysis and continuous variables were evaluated using Student's t test. RESULTS: A total 96 cases of colorectal cancer-related PLA were collected from the previous literature. Most patients (60%) were male and 40% cases occurred in the age group of 61-70 years. Apart from some special types of PLA, there were significant differences in the microbiological spectrum between Eastern Asia and non-Eastern Asian countries, which implied different risk factors and courses of the disease. Gram negative bacteria especially Klebsiella pneumoniae (K. pneu- moniae ) PLA was predominant in Eastern Asia (80.0%) in contrast to non-Eastern Asian countries (P < 0.01). Meanwhile, most of the Eastern Asian patients exhibited smaller size of liver abscess and atypical presentation. Sigmoid colon and rectum (72.73%) were the main sites of tumor in Eastern Asian patients, whereas tumor sites were uneven among most of the non-Easter Asian PLA patients. CONCLUSION:K. pneumoniae PLA was strongly associated with colorectal cancer, especially those occurring in sigmoid colon and rectum, in elderly Eastern Asian male patients. | Kai Qu Chang Liu Zhi-Xin Wang Feng Tian Ji-Chao Wei Ming-Hui Tai Lei Zhou Fan-Di Meng Rui-Tao Wang Xin-Sen Xu | 2012 | World Journal of Gastroenterology2012，18，23： | 12 |
| 17 | Supra-(carbon nanodots) with a strong visible to near-infrared absorption band and efficient photothermal conversion显示文摘A novel concept and approach to engineering carbon nanodots(CNDs)were explored to overcome the limited light absorption of CNDs in low-energy spectral regions.In this work,we constructed a novel type of supra-CND by the assembly of surface charge-confined CNDs through possible electrostatic interactions and hydrogen bonding.The resulting supra-CNDs are the first to feature a strong,well-defined absorption band in the visible to near-infrared(NIR)range and to exhibit effective NIR photothermal conversion performance with high photothermal conversion efficiency in excess of 50%. | Di Li Dong Han Song-Nan Qu Lei Liu Peng-Tao Jing Ding Zhou Wen-Yu Ji Xiao-Yun Wang Tong-Fei Zhang De-Zhen Shen | 2016 | Light(Science & Applications)2016，5，1： | 12 |
| 18 | Species diversification and phylogeographical patterns of birds in response to the uplift of the Qinghai-Tibet Plateau and Quaternary glaciations显示文摘 | Fumin LEI Yanhua QU Gang SONG | 2014 | Current Zoology2014，60，2： | 12 |
| 19 | Practical performance and its efficiency of arsenic removal from groundwater using Fe-Mn binary oxide显示文摘A treatment unit packed by granular adsorbent of Fe-Mn binary oxide incorporated into diatomite (FMBO(1:1)-diatomite) was studied to remove arsenic from anaerobic groundwater without any pre-treatment or post-treatment. The raw anaerobic groundwater containing 35-45 μg/L of arsenic was collected from suburb of Beijing. Arsenic(III) constituted roughly 60%-80% of the total arsenic content. Approximately 7,000 bed volumes (ratio of efluent volume to adsorbent volume) treated water with arsenic concentration below 10 μg/L were produced in the operation period of four months. The regeneration of FMBO(1:1)-diatomite had been operated for 15 times. In the first stage, the regeneration process significantly improved the adsorption capacity of FMBO(1:1)-diatomite. With increased loading amount of Fe-Mn binary oxide, the adsorption capacity for arsenic decreased 20%-40%. Iron and manganese in anaerobic groundwater were oxidized and adsorptive filtrated by FMBO(1:1)-diatomite efficiently. The final concentrations of iron and manganese in efluents were nearly zero. The continued safe performance of the treatment units proved that adsorbent FMBO(1:1)-diatomite had high oxidation ability and exhibited strong adsorptive filtration. | Fangfang Chang Jiuhui Qu Ruiping Liu Xu Zhao Pengju Lei | 2010 | Journal of Environmental Sciences2010，22，1： | 11 |
| 20 | Antifibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline on bile duct ligation induced liver fibrosis in rats显示文摘AIM:To investigate the preventive effect of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) on bile duct ligation (BDL)induced liver fibrosis in rats. METHODS:Liver fibrosis in rats was induced by BDL and AcSDKP was infused subcutaneously for 2 wkvia a osmotic minipump (Alzet 2ML4) immediately after BDL operation. After scarifying, serum and liver specimens were collected. Hematoxylin and eosin staining, Sirius red staining, enzyme linked immunosorbent assay, Western blot or real-time polymerase chain reaction were used to determinate liver functions, histological alterations, collagen deposition, mRNA expression of markers for fibroblasts, transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7). RESULTS:When compared to model rats, chronic exogenous AcSDKP infusion suppressed profibrogenicTGF-β1 signaling, α-smooth muscle actin positivity (α-SMA), fibroblast specific protein-1 (FSP-1) staining and collagen gene expression. Col Ⅰ, Col Ⅲ, matrix metalloproteinase-2, tissue inhibitors of metallopro-teinase-1 and tissue inhibitors of metalloproteinase-2 mRNA expressions were all significantly downregulated by AcSDKP infusion (2.02 ± 1.10vs 14.16 ± 6.50, 2.02 ± 0.45vs 10.00 ± 3.35, 2.91 ± 0.30vs 7.83 ± 1.10, 4.64 ± 1.25 vs 18.52 ± 7.61, 0.46 ± 0.16 vs 0.34 ± 0.12, respectively, P < 0.05). Chronic exogenous AcSDKP infusion attenuated BDL-induced liver injury, inflammation and fibrosis. BDL caused a remarkable increase in alanine transaminase, aspartate transaminase, total bilirubin, and prothrombin time, all of which were reduced by AcSDKP infusion. Mast cells, collagen accumulation, α-SMA, TGF-β1, FSP-1 and BMP-7 increased. The histological appearance of liver specimens was also improved. CONCLUSION:Infusion of exogenous AcSDKP attenu-ated BDL-induced fibrosis in the rat liver. Preservation of AcSDKP may be a useful therapeutic approach in the management of liver fibrosis. | Lei Zhang Lei-Ming Xu Yuan-Wen Chen Qian-Wen Ni Min Zhou Chun-Ying Qu Yi Zhang | 2012 | World Journal of Gastroenterology2012，18，37： | 11 |
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