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| 1 | A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase显示文摘 | Wu SP Fu AL Wang YX Yu LP Jia PY Li Q Jin GZ Sun MJ | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 2 | 癫痫为首发症状的儿童甲状旁腺功能减退无需抗癫痫药物治疗显示文摘背景癫痫临床表现具有多样化,从不受控制的抽搐运动(强直-阵挛性发作)到瞬间失去知觉(失神发作)。大脑电脉冲传播到大脑相邻区域并产生不受控制的电活动风暴。癫痫发病机制可分为六类:代谢、结构、遗传、免疫、炎症、特发性。甲状旁腺功能减退是一种由于甲状旁腺激素(Parathyroid hormone,PTH)缺失或任何激素功能抵抗导致的内分泌疾病,表现主要包括低钙血症,高磷血症和异常PTH水平。 | 邹丽萍 Liu MJ Li JW Shi XY | 2017 | 癫痫杂志2017，3，2： | 5 |
| 3 | Can the rat donor liver tolerate prolonged warm ischemia?显示文摘INTRODUCTIONThe last two decades of the twentieth century havewitnessed increasingly successful rates of livertransplantation.The number of liver transplantations hasincreased steadily while the number of organ donors | Yan JQ Li HW Cai WY Zhang MJ Yang WP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 4 | p53/microRNA-214/ULK1信号通路调控的自噬在糖尿病肾病中的作用机制显示文摘目前有多个研究证实糖尿病肾病中存在自噬失调,但其潜在的病理机制并不清楚。该研究通过对糖尿病小鼠及糖尿病患者肾脏组织分析发现,自噬反应在肾脏中均明显被抑制。特异性敲除小鼠肾脏近端小管的自噬相关基因Atg6后可抑制自噬作用,导致糖尿病小鼠肾脏肥大,加重小管损伤、炎症反应及纤维化,最终导致蛋白尿增加,说明自噬在糖尿病肾病中起保护作用。与此同时,研究发现糖尿病组织中小RNA214(miR-214)表达上调,从而抑制下游unc-51样自噬相关激活酶(ULK1)的表达,最终导致自噬表达降低。特异性沉默肾脏近端小管miR-214的表达可减少对ULK1的抑制,阻止了糖尿病肾病肾脏体积的增大,降低了蛋白尿水平。 | Ma Z Li L Livingston MJ 梅淑钦(编译) | 2021 | 中华医学杂志2021，101，42： | 2 |
| 5 | Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model显示文摘 | Wang H Zheng MH Zhang HB Zhu J He JR Lu AG Ji YB Zhang MJ Jiang Y Yu BM Li HW | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 6 | EPIMEDOKOREANONE A FROM THE AERIAL PARTS O FEPIMEDIUM KOREANUM NAKAI显示文摘EPIMEDOKOREANONEAFROMTHEAERIALPARTSOFEPIMEDIUMKOREANUMNAKAIWenKuiLI;JunShanYANG;PeiGenXIAO(InstituteofMedicinalPlantDevelopme... | Li, WK Yang, JS Xiao, PG Pan, JQ Lu, MJ Zhang, RY | 1996 | Chinese Chemical Letters1996，7，1： | 2 |
| 7 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 8 | Efficient ruthenium-catalyzed racemization of secondary alcohols:application to dynamic kinetic resolution 显示文摘 | Elzinga MJ Li YX | 2002 | Tetrahedron:Asymmetry2002，13，8： | 1 |
| 9 | Free insulin-like growth factor 1 and breast cancer risk显示文摘 | Li BD Khosravi MJ Berkel HJ | 2001 | Int J Cancer2001，91，5： | 1 |
| 10 | Genome remodelling in a basal-like breast cancer metastasis and xenograft显示文摘 | Ding L Ellis MJ Li S Larson DE | 2010 | Nature2010，464，7291： | 1 |
| 11 | Sequential liver and bone biochemical changes in hyperthyroidism:Prospective controlled follow up study 显示文摘 | Huang MJ Li KL Wei JS | 1994 | Am J Gastroenterol1994，89，7： | 1 |
| 12 | Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity显示文摘 | Friedman MJ Wang CE Li XJ | 2008 | J Biol Chem2008，283，13： | 1 |
| 13 | A prospective study of plasma selenium levels and prostate cancer risk显示文摘 | Li H Stampfer MJ Giovannucci EL | 2004 | J Natl Cancer Inst2004，96，： | 1 |
| 14 | Acquired factor Ⅷ inhibitor treated with cyclophosphamide,vincristine,and prednisone显示文摘 | Lian EC Villar MJ Noy LI | 2002 | Am J Hematol2002，69，4： | 1 |
| 15 | Optimization of a novel and improved thermosensitive liposome formulated with DPPC and a Brij surfactant using a robust in vitro system 显示文摘 | Tagami T Ernsting MJ Li SD | 2011 | J Cantrall Release2011，154，3： | 1 |
| 16 | Endotoxin tolerance induced by lipopo- lysaccharides derived fi'om Porphyromonas gilagivalis and Esehe- richia coli:ahernations in Toll-like receptor 2 and 4 signaling path- way显示文摘 | Sun Y Li H Sun MJ | 2014 | Inflammatiola2014，37，1： | 1 |
| 17 | The effect of multiple reexcisions on the risk of local recurrence after breast conserving surgery显示文摘 | O'Sullivan MJ Li T Freedman G | 2007 | Ann Surg Oncol2007，14，11： | 1 |
| 18 | CD20-mediated apoptosis: Signaling through lipid rafts显示文摘 | Deans JP Li H Polyak MJ | 2002 | Immunology2002，107，2： | 1 |
| 19 | Endoglin expression as a measure of microvessel density in cervical cancer 显示文摘 | Brewer CA Setterdahl JJ Li MJ | 2000 | Obstet Gynecol2000，96，2： | 1 |
| 20 | Cardiac involvement in systemic lupus erythematosus detected by echocardiography显示文摘 | Crozier IG Li E Milne MJ | 1990 | Am J Cardiol1990，65，： | 1 |
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