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| 1 | Regulation of glucose and lipid metabolism in health and disease显示文摘Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals, is a key component of cell membranes although it does not generate ATP. The metabolisms of glucose, fatty acids and cholesterol are often intertwined and regulated. For example, glucose can be converted to fatty acids and cholesterol through de novo lipid biosynthesis pathways. Excessive lipids are secreted in lipoproteins or stored in lipid droplets. The metabolites of glucose and lipids are dynamically transported intercellularly and intracellularly, and then converted to other molecules in specific compartments. The disorders of glucose and lipid metabolism result in severe diseases including cardiovascular disease, diabetes and fatty liver. This review summarizes the major metabolic aspects of glucose and lipid, and their regulations in the context of physiology and diseases. | Ligong Chen Xiao-Wei Chen Xun Huang Bao-Liang Song Yan Wang Yiguo Wang | 2019 | Science China(Life Sciences)2019，62，11： | 40 |
| 2 | The SLC transporter in nutrient and metabolic sensing, regulation, and drug development显示文摘The prevalence of metabolic diseases is growing worldwide. Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic diseases. Consistent with metabolic characteristics, the top five organs in which SLC transporters are highly expressed are the kidney, brain, liver, gut, and heart. We aim to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets. SLC transporters serve as Metabolic gate’ of cells and mediate the transport of a wide range of essential nutrients and metabolites such as glucose, amino acids, vitamins, neurotransmitters, and inorganic/metal ions. Gene-modified animal models have demonstrated that SLC transporters participate in many important physiological functions including nutrient supply, metabolic transformation, energy homeostasis, tissue development, oxidative stress, host defense, and neurological regulation. Furthermore, the human genomic studies have identified that SLC transporters are susceptible or causative genes in various diseases like cancer, metabolic disease, cardiovascular disease, immunological disorders, and neurological dysfunction? Importantly, a number of SLC transporters have been successfully targeted for drug developments。 This review will focus on the current understanding of SLCs in regulating physiology, nutrient sensing and uptake, and risk of diseases. | Yong Zhang Yuping Zhang Kun Sun Ziyi Meng Ligong Chen | 2019 | Journal of Molecular Cell Biology2019，11，1： | 11 |
| 3 | Memory T cells: strategies for optimizing tumor immunotherapy显示文摘Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells.Furthermore,the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors.Thus,a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors.This review focuses on recent advances in efficacy against tumors,the origin,formation mechanisms of memory T cells,and the role of the gut microbiota in memory T cell formation.Furthermore,we summarize strategies to generate memory T cells in (ex) vivo that,might be applicable in clinical practice. | Qingjun Liu Zhongjie Sun Ligong Chen | 2020 | Protein & Cell2020，11，8： | 10 |
| 4 | Synthesis and Application of Novel Triazine-Based Charring-Foaming Agents in Intumescent Flame Retardant Polypropylene显示文摘Three novel triazine-based charring-foaming agents (M2-CFA,M4-CFA,and M6-CFA) were synthesized successfully with only water as the solvent and were characterized by FT-IR and thermal gravimetric analysis (TGA).These three charring-foaming agents and the byproduct 944-by were employed to study the effectiveness of the novel intumescent flame retardant dopant on the fire retardancy of polypropylene (PP) investigated through UL-94 and limiting oxygen index (LOI) tests.TGA results showed that the M4-CFA presented good char formation ability (char residue: 26.8% at 700 ℃).It was found that the sample with a 2/1 mass ratio of APP to M4-CFA exhibited the best flame retardancy among all the PP composites: 35.5% LOI and a V-0 rating of UL-94.Additionally,the microstructure and morphology of char residues were further studied by XRD,Raman spectroscopy and SEM. | Ligong Chen Yanyan Yuan Bowei Wang Na Liu Yuzhi Xing Yang Li | 2017 | Transactions of Tianjin University2017，23，3： | 9 |
| 5 | All-optical 2R regeneration based on self-induced polarization rotation in a single semiconductor optical amplifier显示文摘An all-optical 2R regeneration based on self-induced polarization rotation in a single semiconductor optical amplifier is presented.A theoretical model is built up to simulate the system performance.Experiment evidence is also provided.An extinction ratio improvement of 8.3 dB is obtained at a bitrate of 10 Gbit/s.In the BER measurements,6 dB improvement of the power penalty is achieved,clearly demonstrating the feasibility of the proposed scheme.Our approach has a simple structure,and allows photonic integration. | DUAN PinXiang CHEN LiGong ZHANG ShangJian ZHOU XiaoLi LIU YongZhi LIU Yong | 2009 | Chinese Science Bulletin2009，54，20： | 7 |
| 6 | A study on solid density primary standard显示文摘The accuracy of solid density primary standard is decided mainly by the accuracy of the diameter measurement of silicon sphere. With traditional five-interferogram algorithm to unwrap phase for di- ameter measurement, the phase steps should be equal to π/2 exactly, but this is almost impossible to achieve in nanometer positioning technique. In order to overcome this defect, we have derived an im- proved five-interferogram algorithm, which not only keeps the high accuracy of traditional five-inter- ferogram algorithm, but also does not require absolute equal step to unwrap phase. Instead, the im- proved five-interferogram algorithm only needs measuring phase shifting. Based on the improved al- gorithm, we have developed a novel interferometer with special etalon, and the cavity length of this etalon can be changed by pressure from vertical direction to realize phase shifting. The accuracy of this interferometer is better than 3 nm and can be improved in future research. | LUO ZhiYong YANG LiFeng GU YingZi GUO LiGong DING JinGan | 2007 | Chinese Science Bulletin2007，52，21： | 6 |
| 7 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 8 | The root structures of 21 aquatic plants in a macrophyte-dominated lake in China显示文摘Aims Aquatic plants play an important role in freshwater ecosystems.Previous works have largely focused on the functional significance of plant above ground parts,with much less attention on the root structures of aquatic plants.In this study,we divided 21 aquatic plants(including five introduced plants)into multiple plant groups(different life forms,monocot/eudicot and introduced/native)with the goal of addressing two questions:(i)what root structures do aquatic plants exhibit,and(ii)are there differences among these plant groups?Methods Twenty-one aquatic plants belonging to four life forms(free-float-ing,emergent,floating-leaved and submerged)were collected at the near flowering stage from a typical macrophyte-dominated lake in the yangtze River Basin,China.The following root topological parameters were quantified:altitude(a),path length(pe),magnitude(M),mean topological length(b),topological index(TI)and normed indices qa and qb.Important Findings The root topological indices TI,qa and qb for the 21 aquatic plants were 0.724±0.013,0.290±0.031 and 0.152±0.024(means±S.E.),respectively,revealing a general pattern of dichotomous branching,except for the aquatic root of Myriophyllum aquati-cum(Vell.)Verdc.,which displays herringbone branching.All three topological indices were significantly lower for monocots(TI=0.700±0.130,qa=0.191±0.149 and qb=0.086±0.236)than eudicots(TI=0.752±0.206,qa=0.405±0.569 and qb=0.229±0.393),indicating that the roots of monocots are typi-cally more dichotomous-like than those of eudicots.Among the four life forms,the three topological indices for emergent plants(TI=0.832±0.006,qa=0.616±0.018 and qb=0.381±0.014)were significantly higher than those of the other three life forms.Overall,there was no difference between the topological indices of introduced and native aquatic plants,but the introduced species M.aquaticum and Alternanthera philoxeroides(Mart.)Griseb.had both aquatic and edaphic roots as well as unusual functions,which may help explain their strong viability. | Xiaolong Huang Ligong Wang Xin Guan Yuanyuan Gao Chunhua Liu Dan Yu | 2018 | Journal of Plant Ecology2018，11，1： | 6 |
| 9 | The solute carrier transporters and the brain:Physiological and pharmacological implications显示文摘Solute carriers(SLCs)are the largest family of transmembrane transporters that determine the exchange of various substances,including nutrients,ions,metabolites,and drugs across biological membranes.To date,the presence of about 287 SLC genes have been identified in the brain,among which mutations or the resultant dysfunctions of 71 SLC genes have been reported to be correlated with human brain disorders.Although increasing interest in SLCs have focused on drug development,SLCs are currently still under-explored as drug targets,especially in the brain.We summarize the main substrates and functions of SLCs that are expressed in the brain,with an emphasis on selected SLCs that are important physiologically,pathologically,and pharmacologically in the blood-brain barrier,astrocytes,and neurons.Evidence suggests that a fraction of SLCs are regulated along with the occurrences of brain disorders,among which epilepsy,neurodegenerative diseases,and autism are representative.Given the review of SLCs involved in the onset and procession of brain disorders,we hope these SLCs will be screened as promising drug targets to improve drug delivery to the brain. | Chengliang Hu Lei Tao Xizhi Cao Ligong Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 6 |
| 10 | He–Ar Isotopic Tracing of Pyrite from Ore-forming Fluids of the Sanshandao Au Deposit, Jiaodong Area显示文摘The Sanshandao Au deposit is located in the famous Sanshandao metallogenic belt,Jiaodong area.To date,accumulative Au resources of 1000 t have been identified from the belt.Sanshandao is a world-class gold deposit with Au mineralization hosted in Early Cretaceous Guojialing-type granites.Thus,studies on the genesis and ore-forming element sources of the Sanshandao Au deposit are crucial.He and Ar isotopic analyses of fluid inclusions from pyrite(the carrier of Au)indicate that the fluid inclusions have 3 He/4 He=0.043–0.21 Ra with an average of 0.096 Ra and 40 Ar/36 Ar=488–664 with an average of 570.8.These values represent the initial He and Ar isotopic compositions of ore-forming fluids for trapped fluid inclusions.The comparison of H–O isotopic characteristics combined with deposit geology and wall rock alteration reveals that the ore-forming fluids of the Sanshandao Au deposit show mixed crust–mantle origin characteristics,and they mainly comprise crust-derived fluid mixed with minor mantle-derived fluid and meteoric water during the uprising process.The ore-forming elements were generally sourced from pre-Cambrian meta-basement rocks formed by Mesozoic reactivation and mixed with minor shallow crustal and mantle components. | HAN Zhenyu YU Xiaowei LI Shoujun Tian Jingxiang WANG Zhongliang YU Xiaojing WANG Ligong | 2019 | Acta Geologica Sinica(English Edition)2019，93，6： | 5 |
| 11 | The physiological role of drug transporters显示文摘Transporters 在人的有机体包括膜蛋白质的最大的家庭,包括溶质搬运人 transporter 和 ATP 有约束力的盒子 transporter 家庭的成员。他们在 xenobiotic 和内长的分子的吸收,分发和排泄起枢轴的作用。Transporters 广泛地在各种各样的人的纸巾被表示并且习惯性地在药开发和赞同的过程期间被评估。在过去的十年,增加证据证明药 transporters 在正常生理学和疾病是重要的。当前, transporters 作为治疗学的目标被利用治疗象糖尿病,主要消沉,高血压和便秘那样的众多的疾病。尽管有 transporter 生物学的地的稳定的生长,多于成员在的一半 ? transporter 总科几乎没有关于他们的内长的底层或生理的功能可得到的很少信息。这评论在 transporter 研究构画出当前的研究方法,并且包括药药和药内长的底层相互作用总结药运输相互作用。最后,我们 ? 也讨论 transporters 的治疗学的观点基于他们的生理并且 pathophysiological 角色。 | Yu Liang Siqi Li Ligong Chen | 2015 | Protein & Cell2015，6，5： | 5 |
| 12 | THERMAL DEBINDING OF A NEW BINDER显示文摘THERMALDEBINDINGOFANEWBINDER①ZhouJicheng,HuangBaiyun,WuEnxi,YuLigong,QuXuanhuiNationalKeyLaboratoryforPowderMetalurgy,Centra... | Zhou Jicheng *, Huang Baiyun , Wu Enxi , Yu Ligong , Qu Xuanhui National Key Laboratory for Powder Metallurgy, Central South University of Technology, Changsha 410083 * Changsha Railway University, Changsha 410075 | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 5 |
| 13 | Photocatalytic degradation of methyl orange over ITO/CdS/ZnO interface composite films显示文摘ITO/CdS/ZnO interface composite films were successfully prepared by subsequent electrodeposition of CdS and ZnO onto indium tin oxide (ITO) glass substrates. The obtained ITO/CdS/ZnO composite films were characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-Vis spectroscopy. The photocatalytic activity of ITO/CdS/ZnO composite films were investigated using methyl orange (MO) as a model organic compound under UV light irradiation. The influence of operating parameters on MO degradation including initial concentration of MO, pH value of solution, and inorganic anion species over the composite films were examined. A blue shift of absorption threshold was observed for the ITO/CdS/ZnO film in comparison with ITO/ZnO film. ITO/CdS/ZnO composite films prepared under specific conditions showed a higher photocatalytic activity than that of ITO/ZnO films. It was also found that the photocatalytic degradation of MO on the composite films followed pseudo-first order kinetics. | WEI Shouqiang, SHAO Zhongcai, LU Xudong, LIU Ying, CAO Linlin, HE Yan School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang 110168, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 4 |
| 14 | Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects显示文摘Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018. | Qihao Wu Bastien Nay Min Yang Yeke Ni Hong Wang Ligong Yao Xuwen Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 15 | Effects on type 2 diabetes complicated with pulmonary tuberculosis:regiment of insulin,isoniazid,rifampicin,pyrazinamide and ethambutol versus the regiment plus Qi-boosting and Yin-nourishing decoction of Traditional Chinese Medicine显示文摘OBjECTIVE:To observe the clinical effect on type 2diabetes mellitus(T2DM) complicated with pulmonary tuberculosis(TB) of insulin,isoniazid,rifampicin,pyrazinamide and ethambutol(conventional medication) administered together with Qi-boosting and Yin-nourishing decoction derived from Traditional Chinese Medicine(TCM).METHODS:A total of 60 patients with T2 DM complicated with pulmonary TB were randomly and equally divided into positive control group and treatment group.The control group was treated with Western conventional regiment(WCR):insulin,isoniazid,rifampicin,pyrazinamide,and ethambutol,whereas the treatment group was given both WCR and Qi-boosting and V/n-nourishing decoction prepared from TCM.RESULTS:After the treatment,20(66.7%) and 11(36.7%) cases showed sputum bacteria negative conversion in the WCR plus TCM group and WCM group respectively(P < 0.05).A total of 25(83.3%)and 18(60%) cases showed improvement in lung lesion in the WCR plus TCM group and WCM group respectively(P < 0.05).Compared with WCR group,fasting plasma glucose and 2-hour postprandial blood glucose levels in the WCR plus TCM group significantly decreased(P < 0.05 and P < 0.01,respectively).CONCLUSION:Qi-boosting and Yin-nourishing decoction combined with the Western medication showed better curative effect in treating T2 DM complicated with pulmonary TB compared with the group using the conventional Western Medicine alone. | Shi Guangcan Zhang Ligong | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 3 |
| 16 | Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?显示文摘The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has infected millions of people and caused tremendous morbidity and mortality worldwide. Effective treatment for coronavirus disease 2019(COVID-19) due to SARSCoV-2 infection is lacking, and different therapeutic strategies are under testing. Host humoral and cellular immunity to SARSCoV-2 infection is a critical determinant for patients’ outcomes. SARS-CoV-2 infection results in seroconversion and production of anti-SARS-CoV-2 antibodies. The antibodies may suppress viral replication through neutralization but might also participate in COVID-19 pathogenesis through a process termed antibody-dependent enhancement. Rapid progress has been made in the research of antibody response and therapy in COVID-19 patients, including characterization of the clinical features of antibody responses in different populations infected by SARS-CoV-2, treatment of COVID-19 patients with convalescent plasma and intravenous immunoglobin products, isolation and characterization of a large panel of monoclonal neutralizing antibodies and early clinical testing, as well as clinical results from several COVID-19 vaccine candidates. In this review, we summarize the recent progress and discuss the implications of these findings in vaccine development. | Ligong Lu Hui Zhang Meixiao Zhan Jun Jiang Hua Yin Danielle JDauphars Shi-You Li Yong Li You-Wen He | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 17 | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China显示文摘Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor prognosis.Almost 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor prognosis.Thus,global institutions have been working to develop mIDH2 inhibitors.SH1573 is a novel mIDH2 inhibitor that we independently designed and synthesised.We have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and safety.First,SH1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal model.It could also promote the differentiation of mutant AML cell lines and granulocytes in PDX models.Then,it was confirmed that SH1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue distribution.Finally,toxicological data showed that SH1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically safe.This research successfully promoted the approval of SH1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,SH1573 was effective and safe. | Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu Du Xian Zhang Luwei Han Liwen Zhao Ligong Lu Hongzhi Du Shengtao Yuan Meixiao Zhan | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 3 |
| 18 | Improved Photovoltaic Performance of MEH-PPV/PCBM Solar Cells via Incorporation of Si Nanocrystals显示文摘当器官的体积异质接面太阳能电池的性能上的第三个部件创作了,我们学习了硅 nanocrystals (SiNCs ) 的效果 poly [2-methoxy,5-(2-ethylhexyloxy )-1,4-phenylene vinylene ](MEH-PPV ):[6,6 ]-phenyl-C61-butyric 酸甲基酉旨(PCBM ) 混合电影。由增加 SiNCs 的合适的数量进 MEH-PPV : PCBM 混合,象外部量效率那样的设备表演,短路电流密度(JSC ) ,和功率变换效率(PCE ) 改善了。在混合的 2.5% SiNCs 的加入导致了 JSC 的 13.6% 改进,它接着导致了 PCE 的 18% 改进直到 2.28% 。改进表演在阴极在从 MEH-PPV/SiNCs 和费用收集的接口的费用产生两个都主要由于改进。 | Quanxiang Yan Lijian Zuo Zhuowei Gu Ligong Yang Rong Wang Mang Wang Hongzheng Chen | 2013 | Chinese Journal of Chemistry2013，31，11： | 2 |
| 19 | Photosensitizer conjugate-functionalized poly(hexamethylene guanidine) for potentiated broad-spectrum bacterial inhibition and enhanced biocompatibility显示文摘Pathogen infection is the main cause of human morbidity and death.Traditional antibiotics usually sterilize bacteria in chemical ways,which tends to develop serious antibiotic resistance.Cationic polymers exhibit good bacterial inhibition with less resistance,but often face severe cytotoxicity toward normal cells.The optimization of polymeric antimicrobials for enhanced bactericidal capacity and improved biocompatibility is quite meaningful.In addition,photodynamic therapy(PDT) is a therapeutic modality with less susceptibility to develop resistance.Herein,a typical commercial polymeric antimicrobial,polyhexamethylene guanidine(PHMG) was selected for current proof-of-concept optimization due to its excellent bactericidal capacity but moderate biocompatibility.Eosin-Y(EoS)was copolymerized to afford EoS-labeled polymer conjugates,poly(2-(dimethylamino) ethyl methacrylate-co-eosin),P(DMAEMA-co-EoS),which was conjugated with PHMG to afford a novel polymeric antimicrobial,P(DMAEMA-co-EoS)-b-PHMG-b-P(DMAEMA-co-EoS),noted as PEoS-PHMG.It could efficiently kill broad-spectrum bacteria by physical damage and photodynamic therapy.Compared with PHMG,the bacterial inhibition of PEoS-PHMG was potentiated after the functionalization.Furthermore,PEoS-PHMG exhibited low cytotoxicity and minimal hemolysis,which was demonstrated by cell viability assays toward LO2 cells and RAW 264.7 cells as well as hemolytic assays against red blood cells.These results confirmed that the resultant PEoS-PHMG could act as promising alternative antibacterial materials with excellent broad-spectrum bacterial inhibition and favorable biocompatibility. | Fengfeng Xiao Bing Cao Liewei Wen Yanhong Su Meixiao Zhan Ligong Lu Xianglong Hu | 2020 | Chinese Chemical Letters2020，31，9： | 2 |
| 20 | A Variational Method for the Fuse-Warhead Coordination Design of an Air-Faced Missile显示文摘This paper presents a variational method for the fuse-warhead coordination design of an air-faced missile, which takes the distribution density of fragments for a variable and the totalprobability of kill of single missile against an air-target for an objective function. | Gao Peiwang(Department of Engineering Safety, Beijing Institute of Technology, 100081, P. R. China)Miao Ligong(Beijing Institute of Electronic System Engineering, 100854, P. R. China)Yao Cuiyou & Ma Xiaoqing(Department of Engineering Safety, Beijing Insti | 1999 | Journal of Systems Engineering and Electronics1999，10，4： | 2 |
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