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| 1 | Dissecting and Enhancing the Contributions of High-Molecular-Weight Glutenin Subunits to Dough Functionality and Bread Quality显示文摘Dear Editor, Seed storage proteins (SSPs) are frequently important determinants of crop quality traits (Shewry and Casey,1999).Dissecting and enhancing the genetic contributions of individual SSPs to their target traits are essential for effectively improving crop quality attributes.However,such a task is often difficult to accomplish,because SSPs are frequently expressed from multigene families and exhibit strong allelic variation.Consequently,detailed knowledge of the function of individual SSPs in crop quality trait is still limited.This scenario is well illustrated by high-molecular-weight glutenin subunits (HMWGSs),a complex family of SSPs that are involved in wheat enduse quality through affecting dough functionality (Békés,2012;Rasheed et al.,2014). | Yiwen Li Xuefi An Ran Yang Xiaomin Guo Guidong Yue Renchun Fan Bin Li Zhensheng Li Kunpu Zhang Zhenying Dong Luyan Zhang Jiankang Wang Xu Jia Hong-Qing Ling Aimin Zhang Xiangqi Zhang Daowen Wang | 2015 | Molecular Plant2015，8，2： | 9 |
| 2 | Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis显示文摘AIM To explore the effectiveness for treating liver fibrosisby combined transplantation of bone marrow-derived endothelial progenitor cells(BM-EPCs) and bone marrow-derived hepatocyte stem cells(BDHSCs) from the liver fibrosis environment.METHODS The liver fibrosis rat models were induced with carbon tetrachloride injections for 6 wk. BM-EPCs from rats with liver fibrosis were obtained by different rates of adherence and culture induction. BDHSCs from rats with liver fibrosis were isolated by magnetic bead cell sorting. Tracing analysis was conducted by labeling EPCs with PKH26 in vitro to show EPC location in the liver. Finally, BM-EPCs and/or BDHSCs transplantation into rats with liver fibrosis were performed to evaluate the effectiveness of BM-EPCs and/or BDHSCs on liver fibrosis.RESULTS Normal functional BM-EPCs from liver fibrosis rats were successfully obtained. The co-expression level of CD133 and VEGFR2 was 63.9% ± 2.15%. Transplanted BM-EPCs were located primarily in/near hepatic sinusoids. The combined transplantation of BM-EPCs and BDHSCs promoted hepatic neovascularization, liver regeneration and liver function, and decreased collagen formation and liver fibrosis degree. The VEGF levels were increased in the BM-EPCs(707.10 ± 54.32) and BM-EPCs/BDHSCs group(615.42 ± 42.96), compared with those in the model group and BDHSCs group(P < 0.05). Combination of BM-EPCs/BDHSCs transplantation induced maximal up-regulation of PCNA protein and HGF m RNA levels. The levels of alanine aminotransferase(AST), aspartate aminotransferase, total bilirubin(TBIL), prothrombin time(PT) and activated partial thromboplastin time in the BMEPCs/BDHSCs group were significantly improved, to be equivalent to normal levels(P > 0.05) compared with those in the BDHSC(AST, TBIL and PT, P < 0.05) and BM-EPCs(TBIL and PT, P < 0.05) groups. Transplantation of BM-EPCs/BDHSCs combination significantly reduced the degree of liver fibrosis(staging score of 1.75 ± 0.25 vs BDHSCs 2.88 ± 0.23 or BMEPCs 2.75 ± 0.16, P < 0.05).CONCLUSION The combined transplantation exhibited maximal therapeutic effect compared to that of transplantation of BM-EPCs or BDHSCs alone. Combined transplantation of autogenous BM-EPCs and BDHSCs may represent a promising strategy for the treatment of liver fibrosis, which would eventually prevent cirrhosis and liver cancer. | Ling Lan Ran Liu Ling-Yun Qin Peng Cheng Bo-Wei Liu Bing-Yong Zhang Song-Ze Ding Xiu-Ling Li | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | Coral reef-like polyanaline nanotubes prepared by a reactive template of manganese oxide for supercapacitor electrode显示文摘由 nanopaticles 组成的珊瑚像礁石的 PANI nanotubes 被锰氧化物的一个反应模板成功地综合。结构被使用 SEM, TEM,和英尺红外描绘,并且这些 nanotubes 的 supercapacitive 行为与周期的 voltammetry (CV ) 被调查,并且 chargedischarge 分别地测试。533 F/g 的一个最大的特定的电容能在 1 mol/L 被完成有 0.2 ~ 0.8 V 的潜在的范围的水的 H2SO4 (对浸透的甘汞电极) 在为 PANI 电极的一种一半房间安装配置,为电气化学的电容器在电极材料建议它的潜在的申请。 | Ling Ren Wang Fen Ran Yong Tao Tan Lei Zhao Ling Bin Kong Long Kang | 2011 | Chinese Chemical Letters2011，22，8： | 8 |
| 4 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 5 | Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, China: a population-based study显示文摘Background:Chronic obstructive pulmonary disease(COPD)is a common public health problem worldwide.Recent studies have reported that socioeconomic status(SES)is related to the incidence of COPD.This study aimed to investigate the association between SES and COPD among adults in Jiangsu province,China,and to determine the possible direct and indirect effects of SES on the morbidity of COPD.Methods:A cross-sectional study was conducted among adults aged 40 years and above between May and December of 2015 in Jiangsu province,China.Participants were selected using a multistage sampling approach.COPD,the outcome variable,was diagnosed by physicians based on spirometry,respiratory symptoms,and risk factors.Education,occupation,and monthly family average income(FAI)were used to separately indicate SES as the explanatory variable.Mixed-effects logistic regression models were introduced to calculate odds ratios(ORs)and 95%confidence intervals(CIs)for examining the SES-COPD relationship.A pathway analysis was conducted to further explore the pulmonary function impairment of patients with different SES.Results:The mean age of the 2421 participants was 56.63±9.62 years.The prevalence of COPD was 11.8%(95%CI:10.5%–13.1%)among the overall sample population.After adjustment for age,gender,residence,outdoor and indoor air pollution,body weight status,cigarette smoking,and potential study area-level clustering effects,educational attainment was negatively associated with COPD prevalence in men;white collars were at lower risk(OR:0.60,95%CI:0.43–0.83)of experiencing COPD than blue collars;compared with those within the lower FAI subgroup,participants in the upper(OR:0.68,95%CI:0.49–0.97)tertiles were less likely to experience COPD.Such negative associations between all these three SES indicators and COPD were significant among men only.Education,FAI,and occupation had direct or indirect effects on pulmonary function including post-bronchodilator forced expiratory volume in 1 s/forced vital capacity(FEV1/FVC),FEV1,FVC,and FEV1 percentage of predicted.Education,FAI,and occupation had indirect effects on pulmonary function indices of all participants mainly through smoking status,indoor air pollution,and outdoor air pollution.We also found that occupation could affect post-bronchodilator FEV1/FVC through body mass index.Conclusions:Education,occupation,and FAI had an adverse relationship with COPD prevalence in Jiangsu province,China.SES has both direct and indirect associations with pulmonary function impairment.SES is of great significance for COPD morbidity.It is important that population-based COPD prevention strategies should be tailored for people with different SES. | Dan-Dan Zhang Jian-Nan Liu Qing Ye Zi Chen Ling Wu Xue-Qing Peng Gan Lu Jin-Yi Zhou Ran Tao Zhen Ding Fei Xu Linfu Zhou | 2021 | Chinese Medical Journal2021，，13： | 5 |
| 6 | Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor显示文摘Chemotherapy-related fatigue(CRF)is increasingly being recognized as one of the severe symptoms in patients undergoing chemotherapy,which not only largely reduces the quality of life in patients,but also diminishes their physical and social function.At present,there is no effective drug for preventing and treating CRF.Ganoderic acid(GA),isolated from traditional Chinese medicine Ganoderma lucidum,has shown a variety of pharmacological activities such as anti-tumor,anti-inflammation,immunoregulation,etc.In this study,we investigated whether GA possessed anti-fatigue activity against CRF.CT26 tumor-bearing mice were treated with 5-fluorouracil(5-FU,30 mg/kg)and GA(50 mg/kg)alone or in combination for 18 days.Peripheral and central fatigue-related behaviors,energy metabolism and inflammatory factors were assessed.We demonstrated that co-administration of GA ameliorated 5-FU-induced peripheral muscle fatigue-like behavior via improving muscle quality and mitochondria function,increasing glycogen content and ATP production,reducing lactic acid content and LDH activity,and inhibiting p-AMPK,IL-6 and TNF-αexpression in skeletal muscle.Co-administration of GA also retarded the 5-FU-induced central fatigue-like behavior accompanied by down-regulating the expression of IL-6,iNOS and COX2 in the hippocampus through inhibiting TLR4/Myd88/NF-κB pathway.These results suggest that GA could attenuate 5-FU-induced peripheral and central fatigue in tumor-bearing mice,which provides evidence for GA as a potential drug for treatment of CRF in clinic. | Abudumijiti Abulizi Ling Hu Ang Ma Fang-yu Shao Hui-ze Zhu Si-mei Lin Guang-ying Shao Yue Xu Jian-hua Ran Jing Li Hong Zhou Dong-mei Lin Lian-fu Wang Min Li Bao-xue Yang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 5 |
| 7 | Fundamentals of coal topping gasification: Characterization of pyrolysis topping in a fluidized bed reactor显示文摘 | Ran Xiong Li Dong Jian Yu Xiaofang Zhang Ling Jin Guangwen Xu | 2009 | Fuel Processing Technology2009，，8： | 3 |
| 8 | Effects of irrigation and nitrogen management on hybrid maize seed production in north-west China显示文摘Scientific irrigation and nitrogen management is important for agricultural production in arid areas. To quantify the effect of water and nitrogen management on yield components, biomass partitioning and harvest index(HI) of maize for seed production with plastic filmmulching, field experiments including different irrigation and N treatments were conducted in arid north-west China in 2013 and 2014. The results indicated that kernel number per plant(KN) was signi ficantly affected by irrigation and N treatments. However, 100-kernel weight was relatively stable. Reducing irrigation quantity signi ficantly increased stem partitioning index(PI_(stem)) and leaf partitioning index(PIl_(eaf)), and decreased ear partitioning index(PI_(ear)) at harvest, but lowering Nrate(from 500 to 100 kg N$hm^(–2))did not signi ficantly reduce PI_(stem), PI leaf, andPIl_(eaf) at harvest. HI was signi ficantly reduced by reducing irrigation quantity, but not by reducing Nrate. Linear relationships were found between KN, PI_(stem), PI leaf,PIl_(eaf) at harvest and HI and evapotranspiration(ET). | Hui RAN Shaozhong KANG Fusheng LI Ling TONG Taisheng DU | 2016 | Frontiers of Agricultural Science and Engineering2016，3，1： | 3 |
| 9 | Responses of water productivity to irrigation and N supply for hybrid maize seed production in an arid region of Northwest China显示文摘Water and nitrogen(N) are generally two of the most important factors in determining the crop productivity. Proper water and N managements are prerequisites for agriculture sustainable development in arid areas. Field experiments were conducted to study the responses of water productivity for crop yield(WP_(Y-ET)) and final biomass(WP_(B-ET)) of film-mulched hybrid maize seed production to different irrigation and N treatments in the Hexi Corridor, Northwest China during April to September in 2013 and also during April to September in 2014. Three irrigation levels(70%–65%, 60%–55%, and 50%–45% of the field capacity) combined with three N rates(500, 400, and 300 kg N/hm^2) were tested in 2013. The N treatments were adjusted to 500, 300, and 100 kg N/hm^2 in 2014. Results showed that the responses of WP_(Y-ET) and WP_(B-ET) to different irrigation amounts were different. WP_(Y-ET) was significantly reduced by lowering irrigation amounts while WP_(B-ET) stayed relatively insensitive to irrigation amounts. However, WP_(Y-ET) and WP_(B-ET) behaved consistently when subjected to different N treatments. There was a slight effect of reducing N input from 500 to 300 kg/hm^2 on the WP_(Y-ET) and WP_(B-ET), however, when reducing N input to 100 kg/hm^2, the values of WP_(Y-ET) and WP_(B-ET) were significantly reduced. Water is the primary factor and N is the secondary factor in determining both yield(Y) and final biomass(B). Partial factor productivity from applied N(PFP_N) was the maximum under the higher irrigation level and in lower N rate(100–300 kg N/hm^2) in both years(2013 and 2014). Lowering the irrigation amount significantly reduced evapotranspiration(ET), but ET did not vary with different N rates(100–500 kg N/hm^2). Both Y and B had robust linear relationships with ET, but the correlation between B and ET(R^2=0.8588) was much better than that between Y and ET(R^2=0.6062). When ET increased, WP_(Y-ET) linearly increased and WP_(B-ET) decreased. Taking the indices of Y, B, WP_(Y-ET), WP_(B-ET) and PFP_N into account, a higher irrigation level(70%–65% of the field capacity) and a lower N rate(100–300 kg N/hm^2) are recommended to be a proper irrigation and N application strategy for plastic film-mulched hybrid maize seed production in arid Northwest China. | RAN Hui KANG Shaozhong LI Fusheng DU Taisheng DING Risheng LI Sien TONG Ling | 2017 | Journal of Arid Land2017，9，4： | 3 |
| 10 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 11 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 12 | Lactate anions participate in T cell cytokine production and function显示文摘After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in Tcells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate(Na L) increased the production of cytokines(such as IFNγ/IL-2/TNFα) more than the addition of sodium chloride(NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, Na L treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the Na L treatment group compared to the Na Cl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function. | Jing Wen Shipeng Cheng Yaguang Zhang Ran Wang Jiefang Xu Zhiyang Ling Liyan Ma Xinghao Ai Bing Sun | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 13 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 14 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘 | XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG | | 0，，08： | 1 |
| 15 | Activation of canonical wnt pathway promotes differentiation of mouse bone marrow‐derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro显示文摘 | Ai‐ran Liu Le Liu Song Chen Yi Yang Hong‐jie Zhao Ling Liu Feng‐mei Guo Xiao‐min Lu Hai‐bo Qiu | 2013 | J Cell Physiol2013，，6： | 1 |
| 16 | Evaluation of four remote sensing based land cover products over China显示文摘 | Ran Youhua Li Xin Lu Ling | 2010 | Intemational Journal of Remote Sensing2010，31，2： | 1 |
| 17 | Lattice Vibration Spectra and Thermal Properties of SrWO4 Single Crystal 显示文摘 | Ling Z C Xia H R Ran D G | 2006 | Chemical Physics Letters2006，426，13： | 1 |
| 18 | Large-scale land cover mapping with the integration of multi-source in- formation based on the Dempster-Shafer theory显示文摘 | Ran Youhua Li Xin Lu Ling | 2012 | In- ternational Journal of Geographical Information Sci- ence2012，26，1： | 1 |
| 19 | A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system显示文摘 | Qianyu Zhang Jie Tang Ling Fu Rui Ran Yayuan Liu Mingqing Yuan Qin He | 2013 | Biomaterials2013，，： | 1 |
| 20 | Evaluation of four remote sensing based land cover products over China显示文摘 | Ran Yonghua Li Xin Lu Ling | 2010 | Int J Re- mote Sens2010，31，2： | 1 |
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