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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Using computational auditory models to predict simultaneous masking data: model comparison显示文摘 | LISA G H LESLIE M C | 1999 | IEEETransactions on Biomedical Engineering1999，46，12： | 1 |
| 3 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 4 | Spread Spectrum Image Steganography显示文摘 | Lisa M Marvel Charles G Boncelet Charles T Retter | 1999 | IEEE Transactions on Image Processing1999，，8： | 1 |
| 5 | Macrophage-mediated immunostimulation modulates therapeutic efficacy of interleukin-2 based chemoimmunotherapy in advanced metastatic melanoma patients显示文摘 | Bernengo M G Quaglino P Cappello N Lisa F Osella-Abate S Fierro M T | | 0，，01： | 1 |
| 6 | The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result form the rapid and prolonged activation of antigen-specific CD8+T cells in vivo显示文摘 | Elizabeth G I Julie M C | 2002 | J Immunol2002，169，： | 1 |
| 7 | Large-scale delinea- tion of secreted protein bio-markers overexpressed in cancer tissue and serum 显示文摘 | John B Lisa M Suzanne G | 2003 | PNAS2003，100，6： | 1 |
| 8 | Prediction of chicken embryo lethality with the avian escherichia coli traits complement resistance,colicin V production,and presence of the increased serum survival,gene cluster(iss)显示文摘 | PENELOPE S G JOHN J M LISA K N | 2003 | Avian Dis- eases2003，47，： | 1 |
| 9 | Effect of calcium supplementation on serum cholesterol and blood pressure 显示文摘 | ROBERD M B LISA F GREG A G | 2000 | Arch Faro Med2000，9，： | 1 |
| 10 | Alzheimer's disease markers,hyperten- sion,and gray matter damage in normal elderly显示文摘 | Lidia G Lisa M Wai T | 2012 | Neurobiology of Aging2012，33，7： | 1 |
| 11 | Determination of the oxidation states of manganese in brain,liver,and heart mitochondria显示文摘 | Thomas E G Lisa M M Claire E G | 2004 | Journal of Neurochemistry2004，88，： | 1 |
| 12 | Glucose-dependent Regulation of Cholesterol Ester Metabolism in Macrophages by Insulin and Leptin 显示文摘 | Lisa O'Rourke Line M G Stephen JY | 2002 | J Biol Chem2002，277，42： | 1 |
| 13 | Biology and therapeutic advances for pediatric osteosarcoma显示文摘 | Neyssa M Mark G Lisa T | 2004 | Oncologist2004，9，4： | 1 |
| 14 | Synthesis and photochronfic behavior of new polyimides containing azobenzene side groups 显示文摘 | Sava I Resmerita A M Lisa G | 2008 | Polymer2008，49，： | 1 |
| 15 | Biodegradation of trichloroethylene and its anaerobic daugh- ter Products in freshwater wetland Sediments 显示文摘 | MICHELLE M L LISA D O DOUGLAS G C | 2001 | Bioremedi- ation Journal2001，5，2： | 1 |
| 16 | Detection rates of clinically significant genomic alterations by microarray analysis for specific anomalies detected by ultrasound显示文摘 | Lisa G Shaffer Jill A Rosenfeld Mindy P Dabell Justine Coppinger Anne M Bandholz Jay W Ellison J Britt Ravnan Beth S Torchia Blake C Ballif Allan J Fisher | 2012 | Prenat Diagn2012，，10： | 1 |
| 17 | Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum 显示文摘 | John B Lisa M Suzanne G | 2003 | PNAS2003，100，6： | 1 |
| 18 | Mutations in an oocyte - derived growth factor gene ( BMP15 ) cause increased ovulation rate and infertility in a dosagesensitive manner显示文摘 | SUSAN M G KENNETH P M LISA M C | 2000 | Nature Genetics2000，25，： | 1 |
| 19 | Postconditioning and protection from reperfusion injury:where do we stand?Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology显示文摘 | OVIZE M BAXTER G F di LISA F | | 0，，03： | 1 |
| 20 | Large-scale delinea- tion of secreted protein bio-markers overexpressed in cancer tissue and serum 显示文摘 | John B Lisa M Suzanne G | 2003 | PNAS2003，100，6： | 1 |
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