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| 1 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 2 | Animal plant warfare and secondary metabolite evolution显示文摘The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of manhood.In recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and herbivores.As a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal physiques.Plants evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest them.As a result of this selective pressure,animals developed special enzymes,e.g.cytochrome P450 monooxigenases(CYP450)that metabolize xenobiotic phytochemicals.As a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as CYP450.Because these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been coined.The evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays. | Steffen WÖLL Sun Hee KIM Henry Johannes GRETEN Thomas EFFERTH | 2013 | Natural Products and Bioprospecting2013，3，1： | 2 |
| 3 | Determinants of directionality in lambda site-specific recombination 显示文摘 | Yin S Thio LL | 1984 | Cell1984，39，32： | 1 |
| 4 | Association mapping of disease loci, by use of a pooled DNA genomic screen 显示文摘 | Barcellos LF Klitz W Field LL | 1997 | Am J Hum Genet1997，61，3： | 1 |
| 5 | Microbial biofilm显示文摘 | COSTERTON J W LEWANDOWSKI Z CALDWE- LL D E | 1995 | Ann Rev Mierobiol1995，49，： | 1 |
| 6 | Unplanned extubation:a local experience显示文摘 | Phoa LL Pek WY Syap W | 2001 | Singapore Med J2001，43，10： | 1 |
| 7 | Glass and medicine显示文摘 | Hench LL Day DE Hland W | 2010 | Int J Appl Glass Sci2010，1，1： | 1 |
| 8 | Refractive complication of cataract surgery after radial keratometry显示文摘 | Koch DD liu W Hyde LL | 1989 | Am J Ophthalmol1989，108，： | 1 |
| 9 | Soil microbial responses to experimental warming and clipping in a tallgrass prairie显示文摘 | Zhang W Parker KM Luo Y Wan S Wallace LL Hu S | 2007 | 中国生物学文摘2007，21，8： | 1 |
| 10 | Bcl-2 engineered MSCs inhibited apoptosis and improved heart function显示文摘 | Li W Ma N Ong LL Nesselmann C | 2007 | Stem Cells2007，25，8： | 1 |
| 11 | Transcriptmne analysis of skin pho- toaging in chinese females reveals the involvement of skin home- ostasis and metabolic change显示文摘 | Yan W Zhang LL Yan L | 2013 | PLoS One2013，8，61： | 1 |
| 12 | Point prevalence surveys of healthcare-associated infection in 13 hospitals in Hubei Province,China,2007-2008显示文摘 | Xie DS Xiong W Xiang LL | 2010 | J Hosp Infect2010，76，2： | 1 |
| 13 | Methadone therapy for opioid dependence显示文摘 | Krambeer LL Mcknelly WV Gabrielli W | 2001 | Am Fam Physician2001，63，12： | 1 |
| 14 | Diabetes-induced apoptosis in rat kidney显示文摘 | Zhang W Khanna P Chan LL | | 0，，01： | 1 |
| 15 | Point prevalence surveys of healthcare associated infection in 13 hospitals in Hubei Province,China,2007 2008显示文摘 | Xie DS Xiong W Xiang LL | | 0，，2： | 1 |
| 16 | Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells 显示文摘 | Zbang J Wang LL Du W | 2014 | PLoS One2014，9，11： | 1 |
| 17 | Bcl-2 engineered MSCs inhibited apoptosis and improved heart function 显示文摘 | Li W Ma N Ong LL | 2007 | Stem Cells2007，25，8： | 1 |
| 18 | Diabetes-induced apoptosis in rat kidney显示文摘 | Zhang W Khanna P Chan LL | 1997 | Biochem Mol Med1997，61，1： | 1 |
| 19 | Exocytosis and uptake of bacteria by isolated haemocyte populations of two crustaceans:evidence for cellular cooperation in the defence reaction of arthropods 显示文摘 | S(o)derhll K Smith V J Johansson M W | 1986 | Cell Tissue Res1986，245，： | 1 |
| 20 | Bcl-2 engineered MSC inhibited apoptosis and improved heart function显示文摘 | Li W Ma N Ong LL | 2007 | Stem Cells2007，25，8： | 1 |
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