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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 3 | Differential effects of TGFbetal and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells显示文摘 | Sheares K K Jeffery T K Long L | 2004 | Am J Physiol Lung Cell Mol Physiol2004，287，5： | 1 |
| 4 | Rural Resident's Attitudes Toward Recreation and Tourism Development显示文摘 | ALLEN L R H R HAFER P T LONG | 1993 | Ournal of Travel Research1993，21，4： | 1 |
| 5 | MMSE-based MDL method for accurate source number estimation 显示文摘 | Huang L Long T Mao K | 2009 | IEEE Letters on Signal Processing2009，16，9： | 1 |
| 6 | Strategy of Doppler Centroid Estimation in Synthetic Aperture Radar 显示文摘 | Long T Liu L Ding Z | 2011 | Radar Sonar & Navigation IET2011，5，3： | 1 |
| 7 | A new method tracing load- deflection equilibrium path of a doubly nonlinear truss 显示文摘 | Liu S T Long Q L | 2012 | Applied Mechanics and Materials2012，16，： | 1 |
| 8 | Developments in high density cherries in the USA显示文摘 | Long L Facteau T Nuňezelisea R | 2005 | Acta Horticulturae2005，667，： | 1 |
| 9 | Phase diagram of C1 + salt aqueous biphasic systems and its ap- plication for C1 recovery显示文摘 | Deng Y F Long T Zhang D L | 2009 | J Chem Eng Data2009，54，： | 1 |
| 10 | Exploring the effects of urban and agricultural land use on surface water chemistry,across a regional atershed, using multivariate statistics显示文摘 | FITZPATRICK M L LONG D T PIJANOWSKI B C | 2007 | AppliedGeochemistry2007，22，8： | 1 |
| 11 | Object oriented unsteady vortex lattice method for flapping flight显示文摘 | Fritz T E Long L N | 2004 | Journal of Aircraft2004，41，6： | 1 |
| 12 | Multimodal analgesia without par- enteral narcotics for total knee arthroplasty显示文摘 | Dorr L D Raya J Long W T et aI | 2008 | J Arthroplasty2008，23，4： | 1 |
| 13 | Integration of methanogensis with simultaneous nitrification and denitrification in a membrane bioreactor显示文摘 | ZHANG D J LU P L LONG T R | | 0，，02： | 1 |
| 14 | Interpolation method for geometric correction in highlysquint synthetic aperture radar显示文摘 | T Long Y Li Z Ding L Liu | 2012 | IET Radar Sonar Navig2012，7，6： | 1 |
| 15 | A naturally occurring retinal hereditary disease rat with similar to congenital stationary night blindness patient's ERG 显示文摘 | Gu YH Li L Long T Shi L | 2002 | Di-si Junyi Daxue Xuebao (J Fourth Mil Med Univ)2002，23，1： | 1 |
| 16 | Corrosion behaviour of Fe-based ferromagnetic (Fe, Ni)-B-Si-Nb bulk glassy alloys in aqueous electrolytes显示文摘 | LONG Z L CHANG C T DING Y H SHAO Y ZHANG P SHEN B L INOUE A | 2008 | J Non-cryst Solids2008，354，： | 1 |
| 17 | Distributed interference manage-ment in two-tier CDMA femtocell networks显示文摘 | DUY T N LONG B L EKRAM H | 2012 | IEEE Trans on Wire-less Commun2012，11，3： | 1 |
| 18 | Conditional het- eroscedasticity with leverage effect in stock returns: evidence from the Chinese stock market 显示文摘 | Long L Albert T Zhang Z | 2014 | Economic Modelling2014，37，1： | 1 |
| 19 | The impact of tourism development on residents' perception of community life 显示文摘 | Allen L R Long P T Perdue R R | 1988 | Journal of Travel Research1988，27，1： | 1 |
| 20 | Resident support for tourism development 显示文摘 | Richard R Perdue P T Long L A | 1990 | Annals of Tourism Research1990，17，4： | 1 |
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