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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 3 | Defining control strategies for microgrids islanded operation 显示文摘 | LOPES J A P MOREIRA C L MADUREIRA A G | 2006 | IEEE Trans on Power Systems2006，21，91： | 1 |
| 4 | An improved perturbation and okservation maximum power point tracking algorithm for PV arrays显示文摘 | Liu Xuejun Luiz A C Lopes | 2004 | IEEE Power Electronics Specialist Con- ference2004，，3： | 1 |
| 5 | Response of antioxidant enzymes in freshwater fish populations (Leuciscus alburnides complex)to inorginanic pollu- tants exposure显示文摘 | Lopes P A Pinheiro T Santos M C | 2001 | Sci Total Environ2001，280，13： | 1 |
| 6 | Active noise control algorithms with reduced channel count and their stability analysis 显示文摘 | Lopes P A C | 2008 | Signal Processing2008，88，4： | 1 |
| 7 | Lunar and solar triggering of earthquakes显示文摘 | Lopes R M C Malin S R C Mazzarella A | 1990 | Physics of the Earth and Planetary interiors1990，59，： | 1 |
| 8 | Defining control strategies for microgrids islanded operation显示文摘 | LOPES J A P MOREIRA C L MADUREIRA A G | 2006 | IEEE Trans Power Syst2006，21，2： | 1 |
| 9 | Defining con- trol strategies for microgrids islanded operation 显示文摘 | Lopes J A P Moreira C L Madureira A G | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 10 | Ad- sorption of H2, CO2, CH4, CO, N2 and H20 in activa- ted carbon and zeolite for hydrogen production显示文摘 | LOPES F V S GRANDE C A RIBEIRO A M | 2009 | Sep- aration Science and Technology2009，，5： | 1 |
| 11 | Panic disorder and social anxiety disorder subtypes in a caffeine challenge test显示文摘 | Nardi A E Lopes F L Freire R C | | 0，，02： | 1 |
| 12 | Diatoms in northeast Pacific surface sediments as paleoceanographic proxies显示文摘 | Lopes C Mix A C Abrantes F | 2006 | Marine Micropaleontology2006，60，1： | 1 |
| 13 | Systematic review of saturated fatty acids on inflammation and circulating levels of adipokines显示文摘 | Santos S Oliveira A Lopes C | 2013 | Nutr Res2013，33，9： | 1 |
| 14 | Performance assessment of active frequency drifting islanding detection methods显示文摘 | Lopes L A C Sun H | 2006 | IEEE Transactions on Energy Conversion2006，21，1： | 1 |
| 15 | Influence of cover crop on water use and performance of vineyard in Mediterranean Portugal显示文摘 | Monteiro A Lopes C M | 2007 | Agriculture Ecosystems and Environment2007，121，： | 1 |
| 16 | Acoustic similarity scores for keyword spotting 显示文摘 | Veiga A Lopes C Sd L | 2014 | Computational Processing of the Portuguese Language2014，8775，： | 1 |
| 17 | Effect of cigarette smoking on serum alpha-tocopherol and the lipid profile in a Portuguese population显示文摘 | LOPES P A SANTOS M C VICENTE L VIEGAS-CRESPO A M | 2004 | Clin Chim Acta2004，348，12： | 1 |
| 18 | Electric load fore- casting using a fuzzy ART&ARTMAP neural network显示文摘 | LOPES M L M MINUSSI C R LOTUFO A D P | 2005 | Applied Soft Computing2005，5，2： | 1 |
| 19 | Variability of cork from Portuguese Quercus suber studied by solidstate C-13-NMR and FTIR spectroscopies显示文摘 | Lopes M Barrow A Veto C | 2001 | Biopolymers2001，62，： | 1 |
| 20 | The associa- tion of fruits, vegetables, antioxidant vitamins and fibre intake with high-sensitivity C-reactive protein sex and body mass index interactions显示文摘 | Oliveira A Rodriguez-Artalejo F Lopes C | 2009 | Eur J Clin Nutr2009，63，11： | 1 |
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