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| 1 | Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging显示文摘坏死是仅仅在象 ischemic 疾病和创伤的大脑损害(TBI ) 那样的病理学的条件下面发生的房间死亡的一种形式。影响组织的非侵略的成像是新奇治疗学的干预的一个关键部件和在病人的治疗回答的测量。这里,我们为察觉报导一条 bimodal 途径并且 TBI 监视。PEGylated poly (lactic-co-glycolic 酸)(PLGA ) nanoparticles (NP ) ,包含两个近红外线(NIR ) fluorophores 和 perfluorocarbons (陆军) ,被指向到坏死的房间。我们使用了象 IRDye 800CW,我们以前为表明了到失去了膜正直的房间的细胞内部的蛋白质的特定的指向那样的花青染料。这里,我们出现在由光成像和氟的符号的坏死的 vivo 察觉特定磁性的回声成像(19 F MRI ) 用最新设计的 PLGA NP (NIR700 + 陆军)-PEG-800CW。量的前 vivo 光成像和 19 在受伤大脑区域并且在主要机关的 NIR 陆军内容的 F 先生光谱学很好被相关。允许的两种形式在里面在 TBI 的一个老鼠模型的坏死的大脑损害的 vivo 鉴定,与比 19 F MRI。我们的结果证实与木钉层并且损坏 TBI 的织物的成功的指向涂的 PLGA NP 的增加的血水池住处时间。包含 NIR 陆军的单个 PLGA NP 启用两个快速由 MRI 的在损害的程度上的从更深的纸巾的 TBI 州、量的 3D 信息的质的光监视。这些指向坏死的 PLGA NP 能潜在地被用于大脑损害的临床的诊断。 | Luis Javier Cruz Ivo Que Markus Aswendt Alan Chan Mathias Hoehn Clemens Lowik | 2016 | Nano Research2016，9，5： | 3 |
| 2 | Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat显示文摘 | Van der Eerden BC Gevers EF Lowik CW | 2002 | Bone2002，30，3： | 2 |
| 3 | Induced illness in interleulin-6(IL-6)knock-out mice:a causal role of IL-6 in the development of the low 3,5,3'-triiodthyronine syndrome显示文摘 | Boelen A M A Lowik C W | 1996 | Endocrinology1996，137，8： | 1 |
| 4 | Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia 显示文摘 | El Seady R Huisman MA Lowik CW | 2008 | Biochem Biophys Res Commun2008，376，2： | 1 |
| 5 | Induced illness in interleukin-6(IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome显示文摘 | Boelen A Mass MA Lowik CM | 1996 | Endocrinology1996，137，12： | 1 |
| 6 | Effects of external Mg2+ and Ca^2+ on branchial osmotic water permeability and prolatin secretion in the teleost fish Sarotherodon mossambi- cus 显示文摘 | Wendelaar B S E Lowik C J M Van der Mcij J C A | 1983 | Gen Comp Endocrinol1983，52，： | 1 |
| 7 | Polypep- tide-polymer bioconjugates显示文摘 | Canalle L A Lowik D W P M van Hest J C M | 2010 | (2hem Soc Rev2010，39，1： | 1 |
| 8 | Bigenicheterozygosity and the development of steroid-resistant focal segmental glomerulosclerosis 显示文摘 | Lowik M Levtchenko E Westra D | 2008 | Nephrol Dial Tran- splant2008，23，10： | 1 |
| 9 | WT-1 and NPHS2 mutation analysis in patients with non-familial steroid-resistant focal-segmental glomerulosclerosis显示文摘 | Lowik MM Levtchenko EN Monnens LA | 2003 | Clin Nephrol2003，59，2： | 1 |
| 10 | Whole-body optical Imaging in animal models to assess cancer development and progression 显示文摘 | Kaijzel EL van der Pluijm G Lowik C | 2007 | Clin Cancer Res2007，13，12： | 1 |
| 11 | Serum uric acid correla-tesin elderly men and women with special reference to body com-position and dietaty intake J显示文摘 | Loene HM EShuis H Lowik MR | 1990 | J C1in Epidemiol1990，11，： | 1 |
| 12 | Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-de pendent pathway显示文摘 | Dang ZC Lowik CW | 2005 | Mol Cell Biochem2005，268，12： | 1 |
| 13 | Bone morphogenetic proteins stimulate angiogenesis through osteoblast -derived vascular endothelial growth factor显示文摘 | Bezooijen RL Lowik CW | 2002 | Endocrinology2002，143，： | 1 |
| 14 | Hedgehog stim- ulates only osteoblastie differentiation of undifferentiated KS- 483 cells显示文摘 | van der Horst G Farih-Sips H Lowik CW et ol | 2003 | Bone2003，33，6： | 1 |
| 15 | Scleros- tin: current knowledge and future perspectives显示文摘 | Moester MJ Papapoulos SE Lowik CW | 2010 | Calcif Tissue Int2010，87，2： | 1 |
| 16 | Peptide-polymer Vesicles Prepared by Atom Transfer Radical Polymeriza- tion显示文摘 | Ayres L Adams P H J Lowik D W P M | 2005 | J Polym Sei Part A:Polym Chem2005，43，24： | 1 |
| 17 | Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis-a review 显示文摘 | Lowik MM | 2009 | Eur J Pediatr2009，168，11： | 1 |
| 18 | Long-term out- come of biopsy-proven, frequently relapsing minimal- change nephrotic syndrome in children显示文摘 | Kyrieleis HA Lowik MM Pronk I | 2009 | Clin J Am Soc Nephrol2009，4，10： | 1 |
| 19 | Expression of estrogen receptor α and β in the epiphyseal plate of the rat显示文摘 | Van D E Geven E F Lowik C W | 2002 | Bone2002，30，： | 1 |
| 20 | Focal segmental glomerulosclerosis in a patienthomozygous for a CD2AP mutation显示文摘 | Lowik MM Groenen P J Pronk I | 2007 | Kidney Int2007，72，10： | 1 |
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