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| 1 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 2 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Tracheostomy in critically ill patienys显示文摘 | Lukas J Stritestky M | 2003 | Bratisl Lek Listy2003，104，78： | 1 |
| 5 | Perfusion CT of the brain:Diagnostic approach for early detection of ischemic stroke 显示文摘 | Klotz E Luka B | 1998 | Radiology1998，209，1： | 1 |
| 6 | A distributed architecture for resource discovery using metadata显示文摘 | Lukas C | 1998 | D-Lib Magazine1998，，6： | 1 |
| 7 | Hemiarthroplasty for man - agement of proximal humeral fractures 显示文摘 | Taller S Krivohlavek M Lukas R | 2007 | Acta Chir Orthop TraumatolCeeh2007，74，： | 1 |
| 8 | Who cooperates on R&D? 显示文摘 | Fritsch M Lukas R | 2001 | Research Policy2001，30，2： | 1 |
| 9 | Perfusion CT of the brain:diagnostic approach for early detection of ischemic stroke显示文摘 | Klotz E Luka B | 1998 | Radiology1998，209，： | 1 |
| 10 | Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke显示文摘 | Koenig M Klotz E Luka B | 1998 | Radiology1998，209，1： | 1 |
| 11 | Perfusion CT of the brain: di- agnostic approach for early detective of ischemia storke显示文摘 | Koenig M Klotz E Luka B | 1998 | Radi-ology1998，209，1： | 1 |
| 12 | Oncogenic alterations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control 显示文摘 | Lukas J Aagaard L Strauss M | 1996 | Cancer Res1996，55，21： | 1 |
| 13 | Review of ECMO (extracorporeal membrane oxygenation) support in criti- cally ill adult patients 显示文摘 | MARASCO S F LUKAS G MCDONALD M | 2008 | Heart Lung Circ2008，17，4： | 1 |
| 14 | The Prad-1/Cyclin D1oncogene product accumulates aberrantly in a subset of colorectal carcinomas显示文摘 | Bartkova J Lukas J Staurs M | 1994 | Int J Cancer1994，58，4： | 1 |
| 15 | Circulating microRNAs (miRNA) in Serum of Patients With Prostate Cancer显示文摘 | Robert Mahn Lukas C. Heukamp Sebastian Rogenhofer Alexander von Ruecker Stefan C. Müller J?rg Ellinger | 2011 | Urology2011，，5： | 1 |
| 16 | Perfusion CT of the brain:diagnostic approach for early detection of ischemic stroke显示文摘 | Koening M Klotz E Luka B | 1998 | Radiology1998，209，2： | 1 |
| 17 | What is the origin of ulce- rative colitis? Still more questions than answers显示文摘 | Lukas M Bortlik M Maratka Z | 2006 | Postgrad Med J2006，82，972： | 1 |
| 18 | Digital camera identification from sensor pattern noise 显示文摘 | LUKAS J FRIDRICH J GOLJAN M | 2006 | IEEE Trails on Infor- mation Forensics and Security2006，1，2： | 1 |
| 19 | Chronic subordinate colony housing (CSC) as a model of chronic psychosocial stress in male rats 显示文摘 | Nyuyki KD1 Beiderbeck DI Lukas M | 2012 | PLoS One2012，7，52： | 1 |
| 20 | Perfusion CT of the brain : diagnostic approach for early detection of ischemic stroke显示文摘 | Koenig M Klotz E Luka B | 1998 | Radiology1998，209，1： | 1 |
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