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| 1 | Functional brain imaging of gastrointestinal sensation in health and disease显示文摘It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifi cally, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain- gut axis) will be briefky outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorderpatients will be highlighted. | Lukas Van Oudenhove Steven J Coen Qasim Aziz | 2007 | World Journal of Gastroenterology2007，13，25： | 9 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Nicotine and inflammatory neurological disorders显示文摘香烟烟是显著地包括肺癌症和呼吸感染增加疾病的发生的一个主要健康风险因素。然而,正在增加吸烟者们有煽动性的一些和 neurodegenerative 疾病的更低的发生的证据。烟碱是香烟烟的主要抑制免疫力的成分,它两个都禁止天生、适应的有免疫力的回答。不同于香烟烟,烟碱还没被认为是致癌物并且事实上,可以作为 neuroprotective 和反煽动性的代理人有治疗学的潜力。这评论提供在免疫系统上总结烟碱的效果的一个提要并且它的(烟碱) 在各种各样的神经病学的疾病上影响。 | Wen-Hua PIAO Denise CAMPAGNOLO Carlos DAYAO Ronald J LUKAS Jie WU Fu-D ong SHI | 2009 | Acta Pharmacologica Sinica2009，30，6： | 3 |
| 4 | Ca^(2+)signaling in plant responses to abiotic stresses显示文摘Adverse variations of abiotic environmental cues that deviate from an optimal range impose stresses to plants.Abiotic stresses severely impede plant physiology and development.Consequently,such stresses dramatically reduce crop yield and negatively impact on ecosystem stability and composition.Physical components of abiotic stresses can be,for example,suboptimal temperature and osmotic perturbations,while representative chemical facets of abiotic stresses can be toxic ions or suboptimal nutrient availability.The sheer complexity of abiotic stresses causes a multitude of diverse components and mechanisms for their sensing and signal transduction.Ca^(2+),as a versatile second messenger,plays multifaceted roles in almost all abiotic stress responses in that,for a certain abiotic stress,Ca^(2+)is not only reciprocally connected with its perception,but also multifunctionally ensures subsequent signal transduction.Here,we will focus on salt/osmotic stress and responses to altered nutrient availability as model cases to detail novel insights into the identity of components that link stress perception to Ca^(2+)signal formation as well as on new insights into mechanisms of Ca^(2+)signal implementation.Finally,we will deduce emerging conceptual consequences of these novel insights and outline arising avenues of future research on the role of Ca^(2+)signaling in abiotic stress responses in plants. | Qiuyan Dong Lukas Wallrad Bader O.Almutairi Jörg Kudla | 2022 | Journal of Integrative Plant Biology2022，64，2： | 2 |
| 5 | Weighed least squares support vector machines: robustness and sparse approximation显示文摘 | Suykens J A K Brabanter J D Lukas L | 2002 | Neurocomputing2002，48，： | 1 |
| 6 | Tracheostomy in critically ill patienys显示文摘 | Lukas J Stritestky M | 2003 | Bratisl Lek Listy2003，104，78： | 1 |
| 7 | Cyclin D1 expression is regulated by the retinoblastoma protein显示文摘 | MULLER H LUKAS J SCHNEIDER A | 2004 | Proc Natl Acad Sci U S A2004，91，8： | 1 |
| 8 | Weigh- ted least squares support vector machines: robustness and sparse approximation 显示文摘 | Suykens J A K De Brabanter J Lukas L Vandewalle J | 2002 | Neurocomputtng2002，48，14： | 1 |
| 9 | WAF1/cip1 gene polymorphism and expression in carcinomas of the breast, ovary and endometrium显示文摘 | Lukas J Groshen S Saffari B | 1997 | Am J Pathol1997，150，1： | 1 |
| 10 | Earnouts in mergers and acquisitions: a game-theoretic option pricing approach 显示文摘 | Lukas E Reuer J J Welling A | 2012 | European Journal of Operational Research2012，223，1： | 1 |
| 11 | Pathways governing Gl/S transition andtheir response to DNA damage 显示文摘 | BARTEK J LUKAS J | 2001 | FEBS Lett2001，490，3： | 1 |
| 12 | Mammalian G1-and S-phase checkpoints in response to DNA damage显示文摘 | Bartek J Lukas J | 2001 | J Curr Opin Cell Biol2001，13，6： | 1 |
| 13 | Weighted least squares support vector machines robustness and sparse approximation显示文摘 | Suykens J A K De Brabanter J Lukas L | 2002 | Nerurocomputing2002，，48： | 1 |
| 14 | Oncogenic alterations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control 显示文摘 | Lukas J Aagaard L Strauss M | 1996 | Cancer Res1996，55，21： | 1 |
| 15 | Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosingspondylitis: a multireader experiment 显示文摘 | LUKAS C BRAUN J VAN DER H D | 2007 | The Journal of Rheumatology2007，34，4： | 1 |
| 16 | The Prad-1/Cyclin D1oncogene product accumulates aberrantly in a subset of colorectal carcinomas显示文摘 | Bartkova J Lukas J Staurs M | 1994 | Int J Cancer1994，58，4： | 1 |
| 17 | Circulating microRNAs (miRNA) in Serum of Patients With Prostate Cancer显示文摘 | Robert Mahn Lukas C. Heukamp Sebastian Rogenhofer Alexander von Ruecker Stefan C. Müller J?rg Ellinger | 2011 | Urology2011，，5： | 1 |
| 18 | Weighted least squares support vector machines: robustness and sparse approximation显示文摘 | Suykens J A K Brabanter J D Lukas L | 2002 | Neurocomputing2002，48，14： | 1 |
| 19 | More than just a focus:The cbromatin re- sponse to DNA damage and its role in genome integrity maintenance 显示文摘 | Lukas J Lukas C Bartek J | 2011 | Nat Cell Biol2011，13，10： | 1 |
| 20 | The pl6-CyclinD/CDK4-PRb pathway as a functional unit frequently altered in melanoma pathogenesis显示文摘 | Lukas P Guldberg J | 1996 | Cancer Res1996，56，23： | 1 |
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