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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects显示文摘In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitatingthe hepatorenal syndrome.Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation.As a bridge to this treatment,knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs,antibiotics,drugs with specific effects on fibrogenesis and inflammation,and drugs that target specific receptors. | S?ren M?ller Jens H Henriksen Flemming Bendtsen | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 3 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 4 | 针吸术和切开引流术治疗急性单纯性肛周脓肿的随机对照研究显示文摘目的:采用针吸术治疗急性单纯性肛周脓肿在切口愈合、功能结局和生活质量方面具有潜在优势,或可作为传统切开引流术的替代方法。本研究的目的是比较针吸术联合术后抗生素使用与传统切开引流术治疗急性肛周脓肿的疗效。主要观察指标为脓肿复发情况,次要观察指标为瘘管形成、切口愈合、生活质量和肛门失禁情况。 | 佟伟华 SØRENSEN K M MÖLLER S QVIST N | 2021 | 结直肠肛门外科2021，27，2： | 6 |
| 5 | Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy显示文摘AIM: To investigate the characteristics of mucosal le-sions and their relation to laboratory data and long-term follow up in breast-fed infants with allergic colitis. METHODS: In this study 31 breast-fed infants were prospectively evaluated (mean age, 17.4 wk) whose rectal bleeding had not ceased after a maternal elimi-nation diet for cow's milk. Thirty-four age-matched and breast-fed infants (mean age, 16.9 wk) with no rectal bleeding were enrolled for laboratory testing as con-trols. Laboratory findings, colonoscopic and histological characteristics were prospectively evaluated in infants with rectal bleeding. Long-term follow-up with differ-ent nutritional regimes (L-amino-acid based formula or breastfeeding) was also included. RESULTS: Iron deficiency, peripheral eosinophilia andthrombocytosis were significantly higher in patients with allergic colitis in comparison to controls (8.4±3.2 μmol/L vs 13.7±4.7 μmol/L, P<0.001; 0.67±0.49 G/L vs 0.33±0.17 G/L, P<0.001; 474±123 G/L vs 376±89 G/L, P<0.001, respectively). At colonosco-py, lymphonodular hyperplasia or aphthous ulceration were present in 83% of patients. Twenty-two patients were given L-amino acid-based formula and 8 contin-ued the previous feeding. Time to cessation of rectal bleeding was shorter in the special formula feeding group (mean, 1.4 wk; range, 0.5-3 wk) when com-pared with the breast-feeding group (mean, 5.3 wk; range, 2-9 wk). Nevertheless, none of the patients ex-hibited rectal bleeding at the 3-mo visit irrespective of the type of feeding. Peripheral eosinophilia and cessa-tion of rectal bleeding after administration of elemental formula correlated with a higher density of mucosal eosinophils. CONCLUSION: Infant hematochezia, after cow's milk allergy exclusion, is generally a benign and probably self-limiting disorder despite marked mucosal abnor-mality. Formula feeding results in shorter time to cessa-tion of rectal bleeding; however, breast-feeding should not be discouraged in long-lasting hematochezia. | Kriszta Molnár Petra Pintér Hajnalka Gyrffy ron Cseh Katalin Eszter Müller András Arató Gábor Veres | 2013 | World Journal of Gastroenterology2013，19，24： | 3 |
| 6 | SolEmuls ? —novel technology for the formulation of i.v. emulsions with poorly soluble drugs显示文摘 | R.H Müller S Schmidt I Buttle A Akkar J Schmitt S Br?mer | 2003 | International Journal of Pharmaceutics2003，，2： | 3 |
| 7 | 水胀式锚杆用作隧道支护显示文摘用水胀式锚杆的及时支护以及用于建立洞口而采用的柱状注浆(Rodinject)加固地层的技术,已成功地用于满足工期紧迫的奥地利Oswaldiberg公路隧道的需要。 | S Müller 李福庭 | 1992 | 铁道建筑1992，32，12： | 2 |
| 8 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 9 | Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry显示文摘 | Michel Y Haller Stephan R Müller Christa S McArdell Alfredo C Alder Marc J.-F Suter | 2002 | Journal of Chromatography A2002，，1： | 2 |
| 10 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 11 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 12 | 超声造影可指导结直肠癌肝转移患者的治疗策略显示文摘【据Journal of Hepatology 2021年2月报道】题:超声造影可指导结直肠癌肝转移患者的治疗策略(作者Sawatzki M等)来自瑞士Kantonsspital的Sawatzki等前瞻性分析2015年12月—2019年5月期间新确诊且经组织学证实的结直肠癌患者资料。在CT进行分期检查后,对296例CT未显示结直肠癌肝转移(CRLM)的患者进行超声造影(CEUS)检查。参考标准为MR或组织学病理,以确诊被CT检查遗漏的CRLM。 | 隋明巍 牛俊奇 SAWATZKI M GüLLER U GüSEWELL S | 2021 | 临床肝胆病杂志2021，37，8： | 2 |
| 13 | 显示文摘 | MüLLER A REUTER H DILLINGER S | 1995 | Angew Chem Int Ed Eng1995，34，： | 1 |
| 14 | Detection and HER2 expression of circulating tumor cells:prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial显示文摘 | Riethdorf S Müller V Zhang L | 2010 | Clin Cancer Res2010，16，9： | 1 |
| 15 | A National Strategic Change in Treatment Policy for Rectal Cancer—Implementation of Total Mesorectal Excision as Routine Treatment in Norway. A National Audit显示文摘 | Arne Wibe M.D. Bj?rn M?ller M.Sc. Jarle Norstein M.D. Erik Carlsen M.D. Ph.D. Johan N. Wiig M.D. Ph.D. Richard J. Heald F.R.C.S. Fr?ydis Langmark M.D. Helge E. Myrvold M.D. Ph.D. Odd S?reide F.R.C.S | 2002 | Diseases of the Colon & Rectum2002，，7： | 1 |
| 16 | Instant volume visualization using maximum intensity difference accumulation 显示文摘 | Bruckner S Gr?ller M E | 2009 | Computer Graphic Forum2009，28，3： | 1 |
| 17 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 18 | PAHs,PCDD/Fs,PCBs and HCB in leaves from Brisbane,Australia显示文摘 | Müller J F Hawker D W McLachlan M S | 2001 | Chemophere2001，43，5： | 1 |
| 19 | ssociation of Filaggrin loss-of-function-mutations with atopic dermatitisand asthma in the Early Treatment of the Atopic Child (ETAC) population显示文摘 | Müller S Marenholz I Lee YA | 2009 | Pediatr Allergy Immunol2009，20，4： | 1 |
| 20 | 查看详情显示文摘 | (O)zyürek Z Komber H Gramm S Schmaljohann D Müller A H E Voit B | | 0，，10： | 1 |
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