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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 3 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 4 | Fretting wear and cracking in sintered metal matrix composites显示文摘 | Martin B Vincent L Wright C S | 2001 | Wear2001，248，1： | 2 |
| 5 | Numerical modeling of median road traffic noise barriers 显示文摘 | Martin S J Hothersail D C | 2002 | Journal of Sound and Vibration2002，251，4： | 2 |
| 6 | Base-pair neutral homozygotes can be discriminated by calibrated high-resolution melting of small amplicons显示文摘 | Gundry C N Dobrowolski S F Martin Y R | 2008 | Nucleic Acids Res2008，36，： | 1 |
| 7 | Mitochondria as the central control point of apoptosis显示文摘 | Desagher S Martinou J C | 2000 | Trends Cell Biol2000，10，： | 1 |
| 8 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 9 | In situ study of austenite formation by dilatometry in a low carbon microalloyed steel显示文摘 | Martin D S Rivera-Dlaz-del Castillo P E J Garcia de-Andres C | 2008 | Scripta Materialia2008，58，10： | 1 |
| 10 | Imagery use in sport:A literature review and applied model 显示文摘 | Martin K A Moritz S E Hall C R | 1999 | The Sport Psychologist1999，13，24： | 1 |
| 11 | Gemeitabine-a safety review 显示文摘 | Aapro MS Martin C Hatty S | 1998 | Anticancer Drugs1998，9，3： | 1 |
| 12 | Sulfuric activation of a brazilian manganese ore for heavy metals removal显示文摘 | RESENDE P C BARRADO F S MARTINS A H | 1999 | Hydrometallurgy1999，51，3： | 1 |
| 13 | Liquid liquid extraction of lactic acid with alamine-336显示文摘 | MARTIN M S PAZOS C COCA J | 1996 | J Chem Tech Biotchnol1996，65，： | 1 |
| 14 | B-type nartruretic peptide limits infract size in rat isolated hearts via KATP channel opening显示文摘 | D'souza S P Yellon D M Martin C | 2003 | Am J Physiol Heart Cric Physiol2003，284，3： | 1 |
| 15 | Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction显示文摘 | Martins S Aguilar C N de la Garza-Rodriguez I | 2010 | Journal of Chemical Technology andBiotechnology2010，85，8： | 1 |
| 16 | Mammalian caspases: structure, activation, substrates, and functions during apoptosis显示文摘 | EARNSHAW W C MARTINS L M KAUFMANN S H | 1999 | Annu Rev Biochem1999，68，： | 1 |
| 17 | PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug显示文摘 | THIRUMALA G SNJEZANA S MARTIN C G | 1999 | J Controlled Rel1999，57，2： | 1 |
| 18 | Immunologic and virology evolution during periods of intermittend and persistent low-level viremia显示文摘 | KARLSSON A C YOUNGER S R MARTIN J N | 2004 | AIDS2004，18，： | 1 |
| 19 | Wilson's disease:a review of misdiagnosed cases显示文摘 | YARZE J C MARTIN P MUNOZ S J | 1995 | QJM1995，88，： | 1 |
| 20 | Effect of extracellular hydrogen on organic acid utilization by the ruminal bacterium Selenomonas ruminantium显示文摘 | Martin S A Park C M | 1996 | J Curr Microbiol1996，32，： | 1 |
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