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| 1 | 柴达木盆地北缘早古生代高压—超高压变质带中发现典型超高压矿物——柯石英显示文摘从都兰北带榴辉岩的片麻岩围岩的锆石中发现了柯石英包裹体和石墨包裹体,说明该超高压带的峰期变质作用已达柯石英稳定区间(>2.8GPa)但小于金刚石的稳定区间(<3.5GPa),从而确定了柴达木盆地北缘存在早古生代超高压变质作用和陆-陆碰撞作用,为中国中部存在一条横贯东西的早古生代(大致500~400Ma)高压超高压变质带的推断提供了新的关键性证据。 | 杨经绥 宋述光 许志琴 吴才来 史仁灯 张建新 李海兵 万渝生 刘焰 邱海峻 刘福来 Shigenori Maruyama | 2001 | 地质学报2001，75，2： | 221 |
| 2 | 含柯石英锆石的SHRIMP U-Pb定年:胶东印支期超高压变质作用的证据显示文摘苏鲁超高压变质带的形成时代究竟是印支期还是新元古代争议始终很大。对山东胶南地区超高压变质带中超镁铁岩和榴辉岩的锆石激光拉曼、阴极发光和离子探针原位定年的研究获得超高压变质作用发生的时代为印支期。其中超镁铁岩含柯石英锆石的年龄为221±12Ma,该深成岩侵位时代为新元古代(581±44Ma)。此外,锆石中另有约400Ma年龄记录,可能代表岩石形成后另有一期热事件。榴辉岩的下交点年龄为228±29 Ma,与超镁铁岩含柯石英锆石年龄一致,代表超高压变质时代;上交点为中元古代(1821±19Ma),代表原岩年龄,后者与其片麻岩围岩时代相一致,说明榴辉岩是原位俯冲。 | 杨经绥 许志琴 吴才来 刘福来 史仁灯 J.Wooden Maruyama | 2002 | 地质学报2002，76，3： | 47 |
| 3 | Association of Fusobacterium nucleatum with immunity andmolecular alterations in colorectal cancer显示文摘The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum(F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6%(44/511), which was lower than that in United States cohort studies(13%). Similar to the United States studies, F. nucleatum positivityin Japanese colorectal cancers was significantly associated with microsatellite instability(MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets(i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain micro RNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. Micro RNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and micro RNA expressions in colorectal cancer. | Katsuhiko Nosho Yasutaka Sukawa Yasushi Adachi Miki Ito Kei Mitsuhashi Hiroyoshi Kurihara Shinichi Kanno Itaru Yamamoto Keisuke Ishigami Hisayoshi Igarashi Reo Maruyama Kohzoh Imai Hiroyuki Yamamoto Yasuhisa Shinomura | 2016 | World Journal of Gastroenterology2016，22，2： | 44 |
| 4 | Current role of ultrasound for the management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)has a decisive influence on the prognosis of cirrhotic patients.Although α-fetoprotein(AFP)is a known and specific tumor maker for HCC,it is not suitable for the screening and surveillance of HCC because of its poor predictive value and low sensitivity.The use of imaging modalities is essential for the screening,diagnosis and treatment of HCC.Ultrasound(US)plays a major role among them,because it provides realtime and non-invasive observation by a simple and easy technique.In addition, US-guided needle puncture methods are frequently required for the diagnosis and/or treatment process of HCC.The development of digital technology has led to the detection of blood flow by color Doppler US, and the sensitivity for detecting tumor vascularity has shown remarkable improvement with the introduction of microbubble contrast agents.Moreover,near real- time 3-dimensional US images are now available.As for the treatment of HCC,high intensity focused ultrasound (HIFU)was developed as a novel technology that provides a transcutaneous ablation effect without needle puncture.These advancements in the US field have led to rapid progress in HCC management,and continuing advances are expected.This article reviews the current application of US for HCC in clinical practice. | Hitoshi Maruyama Masaharu Yoshikawa Osamu Yokosuka | 2008 | World Journal of Gastroenterology2008，14，11： | 24 |
| 5 | Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultra-high pressure zone of Dabie Mountains,China显示文摘The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dabie Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that ( i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2 -bearing fluids were presentin the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite. | LIU Jingbo YE Kai CONG Bolin Maruyama Shegnori FAN Hongrui | 2001 | Chinese Science Bulletin2001，46，22： | 22 |
| 6 | Investigation and prediction of enteral nutrition problems after percutaneous endoscopic gastrostomy显示文摘AIM:To investigate and predict enteral nutrition problems after percutaneous endoscopic gastrostomy (PEG). METHODS:We retrospectively analyzed data for 252 out of 285 patients who underwent PEG at our hospital from 1999 to 2008.Enteral nutrition problems after PEG were defined as:(1)patients who required ≥1 mo after surgery to switch to complete enteral nutrition,or who required additional parenteral alimentation continuously;or(2)patients who abandoned switching to enteral nutrition using the gastrostoma and employed other nutritional methods. We attempted to identify the predictors of problem cases by using a logistic regression analysis that examined the patients’backgrounds and the specific causes that led to their problems. RESULTS:Mean age of the patients was 75 years,and in general,their body weight was low and their overall condition was markedly poor.Blood testing revealed that patients tended to be anemic and malnourished.A total of 44 patients(17.5%)were diagnosed as having enteral nutrition problems after PEG.Major causes ofthe problems included pneumonia,acute enterocolitis (often Clostridium difficile-related),paralytic ileus and biliary tract infection.A multivariate analysis identified the following independent predictors for problem cases:(1)enteral nutrition before gastrectomy(a risk reduction factor);(2)presence of esophageal hiatal hernia;(3)past history of paralytic ileus;and(4) presence of chronic renal dysfunction. CONCLUSION:Enteral nutrition problems after PEG occurred at a comparatively high rate.Patient background analysis elucidated four predictive factors for the problem cases. | Shiro Yokohama Masaru Aoshima Yukiomi Nakade Junya Shindo Junichi Maruyama Masashi Yoneda | 2009 | World Journal of Gastroenterology2009，15，11： | 14 |
| 7 | Mineral inclusions of zircon and UHP metamorphic evidence from paragneiss and orthogneiss of pre-pilot drill-hole CCSD-PP2 in north Jiangsu Province,China显示文摘Coesite inclusions, together with omphacite, jadeite, garnet and phengite inclusions, were identified in zircons separates from almost all gneissic core samples of pre-pilot drillhole CCSD-PP2 by the Laser Raman spectros-copy and the cathodoluminescence method. These data indicate that gneissic rocks consisting of paragneisses and or-thogneisses ubiquitously experienced UHP metamorphism. This research may be of great significance for an in-depth study of the subduction-exhumation mechanism of the Sulu UHP metamorphic belt and selecting the drilling site for the Chinese Continental Scientific Drilling Project. | LIU Fulai XU Zhiqin YANG Jingsui S Maruyama J.G.Liou I.Katayama H.Masago | 2001 | Chinese Science Bulletin2001，46，12： | 12 |
| 8 | Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate显示文摘A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor(GIST) . Computed tomography(CT) and magnetic resonance imaging(MRI) 107 mo after the operation,revealed a cystic mass(14 cm in diameter) and a solid mass(9 cm in diameter) in the right and left lobes of the liver,respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate(IM) treatment,400 mg/day orally. Following the IM treatment for a period of 35 mo,the patient underwent partial hepatectomy(S4 + S5) . The effect of IM on the metastatic lesions was interpreted as pathologic complete response(CR) . Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported. | Seiji Suzuki Koji Sasajima Masayuki Miyamoto Hidehiro Watanabe Tadashi Yokoyama Hiroshi Maruyama Takeshi Matsutani Aimin Liu Masaru Hosone Shotaro Maeda Takashi Tajiri | 2008 | World Journal of Gastroenterology2008，14，23： | 11 |
| 9 | Origin of the Earth:A proposal of new model called ABEL显示文摘The Earth was born as a dry planet without atmosphere and ocean components at 4.56 Ga,with subsequent secondary accretion of bio-elements,such as carbon(C),hydrogen(H),oxygen(O),and nitrogen(N) which peaked at 4.37-4.20 Ga.This two-step formation model of the Earth we refer to as the advent of bio-elements model(ABEL Model) and the event of the advent of bio-elements(water component) as ABEL Bombardment.It is clear that the solid Earth originated from enstatite chondrite-like dry material based on the similarity in oxygen isotopic composition and among other isotopes.On the other hand,Earth's water derives primarily from carbonaceous chondrite material based on the hydrogen isotopic ratio.We present our ABEL model to explain this enigma between solid Earth and water,as well as secondary accretion of oxidizing bio-elements,which became a precursor to initiate metabolism to emerge life on a highly reductive planet.If ABEL Bombardment had not occurred,life never would have emerged on the Earth.Therefore,ABEL Bombardment is one of the most important events for this planet to evolve into a habitable planet.The chronology of ABEL Bombardment is informed through previous researches of the late heavy bombardment and the late veneer model.ABEL Bombardment is considered to have occurred during 4.37-4.20 Ga,which is the concept to redefine the standard late heavy bombardment and the late veneer models.Also,ABEL Bombardment is the trigger of the transition from stagnant lid tectonics to plate tectonics on this planet because of the injection of volatiles into the initial dry Earth. | Shigenori Maruyama Toshikazu Ebisuzaki | 2017 | Geoscience Frontiers2017，8，2： | 10 |
| 10 | Autonomy in materials research: a case study in carbon nanotube growth显示文摘Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is slow.Our current research process is human-centred,where human researchers design,conduct,analyse and interpret experiments,and then decide what to do next.We have built an Autonomous Research System(ARES)—an autonomous research robot capable of first-of-its-kind closed-loop iterative materials experimentation.ARES exploits advances in autonomous robotics,artificial intelligence,data sciences,and high-throughput and in situ techniques,and is able to design,execute and analyse its own experiments orders of magnitude faster than current research methods.We applied ARES to study the synthesis of singlewalled carbon nanotubes,and show that it successfully learned to grow them at targeted growth rates.ARES has broad implications for the future roles of humans and autonomous research robots,and for human-machine partnering.We believe autonomous research robots like ARES constitute a disruptive advance in our ability to understand and develop complex materials at an unprecedented rate. | Pavel Nikolaev Daylond Hooper Frederick Webber Rahul Rao Kevin Decker Michael Krein Jason Poleski Rick Barto Benji Maruyama | 2016 | npj Computational Materials2016，，1： | 9 |
| 11 | Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2:A project of the Kyushu University Liver Disease Study Group显示文摘瞄准:决定一座干扰素高山的功效哈并且为感染遗传型 2 的丙肝病毒(HCV ) 的日本病人的 ribavirin 联合治疗,多中心研究回顾地被分析。方法:总共,有 HCV 遗传型 2 的 173 个病人每天一个星期和 ribavirin 的 600-800 mg 为 24 wk 三次皮下地收到 interferon-alpha。结果:总的来说持续的 virological 反应(SVR ) ,在浆液的定义同样无法发现的 HCV RNA,在治疗的结束以后的 24 wk,在 84.4% 显著地高,(146/173 ) 由 intention-to-treat 分析。在 SVR 的有效差量有或没有 ribavirin (46.9% 对 92.9%) 的中止在病人之间被发现,但是没有差别有或没有 ribavirin 的剂量减小在那些之间被发现。在 SVR 的有效差量也与 16 或更与不到 16 wk 和病人在病人之间被发现 ribavirin 治疗(34.8% 对 92.0%) 的星期。结论:24-wk 干扰素和 ribavirin 治疗为有 HCV 遗传型 2 的日本病人是高度有效的。SVR 的重要预言者是 ribavirin 治疗的继续多达 16 个星期。 | Norihiro Furusyo Masaki Katoh Yuichi Tanabe Eiji Kajiwara Toshihiro Maruyama Junya Shimono Hironori Sakai Makoto Nakamuta Hideyuki Nomura Akihide Masumoto Shinji Shimoda Kazuhiro Takahashi Koichi Azuma Jun Hayashi Kyushu University Liver Disease Study Group | 2006 | World Journal of Gastroenterology2006，12，5： | 8 |
| 12 | Initiation of plate tectonics in the Hadean: Eclogitization triggered by the ABEL Bombardment显示文摘When plate tectonics began on the Earth has been long debated and here we argue this topic based on the records of Earth-Moon geology and asteroid belt to conclude that the onset of plate tectonics was during the middle Hadean(4.37-4.20 Ga). The trigger of the initiation of plate tectonics is the ABEL Bombardment, which delivered oceanic and atmospheric components on a completely dry reductive Earth, originally comprised of enstatite chondrite-like materials. Through the accretion of volatiles, shock metamorphism processed with vaporization of both CI chondrite and supracrustal rocks at the bombarded location, and significant recrystallization went through under wet conditions, caused considerable eclogitization in the primordial continents composed of felsic upper crust of 21 km thick anorthosite, and 50 km or even thicker KREEP lower crust. Eclogitization must have yielded a powerful slab-pull force to initiate plate tectonics in the middle Hadean. Another important factor is the size of the bombardment. By creating Pacific Ocean class crater by 1000 km across impactor, rigid plate operating stagnant lid tectonics since the early Hadean was severely destroyed, and oceanic lithosphere was generated to have bi-modal lithosphere on the Earth to enable the operation of plate tectonics.Considering the importance of the ABEL Bombardment event which initiated plate tectonics including the appearance of ocean and atmosphere, we propose that the Hadean Eon can be subdivided into three periods:(1) early Hadean(4.57-4.37 Ga),(2) middle Hadean(4.37-4.20 Ga), and(3) late Hadean(4.20-4.00 Ga). | Shigenori Maruyama M.Santosh Shintaro Azuma | 2018 | Geoscience Frontiers2018，9，4： | 8 |
| 13 | Doppler study of hepatic vein in cirrhotic patients:Correlation with liver dysfunction and hepatic hemodynamics显示文摘AIM: To elucidate the significance of Doppler measurements of hepatic vein in cirrhotic patients and to correlate with liver dysfunction and hepatic hemodynamics. METHODS: One hundred patients with liver cirrhosis and 60 non-cirrhotic controls were studied. Doppler waveforms were obtained from right hepatic vein and flow velocity measured during quiet respiration. Doppler measurements were also obtained from portal trunk, right portal vein and proper hepatic artery. RESULTS: Hepatic vein waveforms were classified into three classical patterns. Flat waveform was uncommon. Mean hepatic vein velocity was significantly higher in cirrhotic patients (12.7 ± 6.4 vs 5.1 ± 2.1 and 6.2 ± 3.2 cm/s; P < 0.0001). The poorer the grade of cirrhosis, the higher was the mean velocity. Maximum forward velocity was never greater than 40 cm/s in controls. Degree of ascites was found to be highly correlated with mean velocity. “Very high” group (≥ 20 cm/s) presented clinically with moderate to massive ascites. Correlations between right portal flow and mean velocity was significant (P < 0.0001, r = 0.687). CONCLUSION: Doppler waveforms of hepatic vein, which is independent of liver dysfunction, should be obtained during normal respiration. Mean hepatic vein velocity reflects the change in hepatic circulation associated with progression of liver cirrhosis. It can be used as a new parameter in the assessment of liver cirrhosis. | KC Sudhamshu Shoiichi Matsutani Hitoshi Maruyama Taro Akiike Hiromitsu Saisho | 2006 | World Journal of Gastroenterology2006，12，36： | 8 |
| 14 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 15 | Fossil Association from the Lower Cambrian Yanjiahe Formation in the Yangtze Gorges Area,Hubei,South China显示文摘摘要:除了以前报导的小壳的石块(SSF ) ,一个宏观的石块集合,包括的丰富的水藻,锥形的管状的石块形式,和可能的印象一放大了后生动物,在西方的湖北省的 Yangtze 峡区域来自更低的寒武纪的 Yanjiahe 形成,华南。可见石块在 thinlaminated siltstone 被保存或泥泞 siltstone 在 815 公里厚的碳酸盐存款之间设置了,浅水里的抑制本地消沉的可能代表的沉积背景在早寒武纪的 Meishucunian 阶段期间焦化站台。宏观的石块协会关于生活的进化提供重要石块证据从对寒武纪的爆炸间隔晚前寒武纪。 | GUO Junfeng LI Yong HAN Jian ZHANG Xingliang ZHANG Zhifei OU Qiang LIU Jianni SHU Degan Shigenori MARUYAMA Tsuyoshi KOMIYA | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 8 |
| 16 | Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis显示文摘AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood. | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 17 | Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction显示文摘Esophageal lymphoepithelioma-like carcinoma(LELC) is extremely rare. We report the first case of esopha-geal LELC showing macroscopic reduction. A 67-year-old male presented with dysphagia and, by endoscopic examination, was found to have a significantly raised tumor of 10 mm in diameter in the thoracic esophagus. The biopsied material showed esophageal cancer. We performed endoscopic submucosal dissection. However, the tumor became flattened, similar to a scar, in only 2 mo. Histologically, the carcinoma cells had infiltrated the submucosal layer. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed aroundthe carcinoma cells. Therefore, this lesion was consid-ered to be an LELC with poorly differentiated squamous cells. Because the margin was positive, an esophagec-tomy was performed. Carcinoma cells were detected in the neck in one lymph node. The staging was T1N0M1 b. However, the patient has been well, without adjuvant therapy or recurrence, for more than 5 years. | Masaya Uesato Tuguaki Kono Tooru Shiratori Yasunori Akutsu Isamu Hoshino Kentarou Murakami Daisuke Horibe Tetsurou Maruyama Yoshihide Semba Ryuma Urahama Yukiko Ogura Takashi Oide Toru Tanizawa Hisahiro Matsubara | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 6 |
| 18 | miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer显示文摘AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of patients.METHODS We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary AFPGC.We next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their utility.We also investigated the expression levels of the selected miRNA not only in tissue but also in plasma samples.Moreover,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant potential.RESULTS Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric mucosa.Conversely,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC patients.In contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC patients.CONCLUSION miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC. | Suguru Maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 6 |
| 19 | Transnasal endoscopic retrograde chalangiopancreatography using an ultrathin endoscope: A prospective comparison with a routine oral procedure显示文摘AIM: To investigate if transnasal endoscopic retrograde cholangiopancreatography (n-ERCP) using an ultrathin forward-viewing scope may overcome the disadvantages of conventional oral ERCP (o-ERCP) related to the large- caliber side-viewing duodenoscope. METHODS: The study involved 50 patients in whom 25 cases each were assigned to the o-ERCP and n-ERCP groups. We compared the requirements of esophagogastroduodenoscopy (EGD) prior to ERCP, rates and times required for successful cannulation into the pancreatobiliary ducts, incidence of post-procedure hyperamylasemia, cardiovascular parameters during the procedure, the dose of a sedative drug, and successful rates of endoscopic naso-biliary drainage (ENBD). RESULTS: Screening gastrointestinal observations were easily performed by the forward-viewing scope and thus no prior EGD was required in the n-ERCP group. There was no significant difference in the rates or times for cannulation, or incidence of hyperamylasemia between the groups. However, the cannulation was relatively difficult in n-ERCP when the scope appeared U-shape under fluoroscopy. Increments of blood pressure and the amount of a sedative drug were significantly lower in the n-ERCP group. ENBD was successfully performed succeeding to the n-ERCP in which mouth-to-nose transfer of the drainage tube was not required. CONCLUSION: n-ERCP is likely a well-tolerable methodwith less cardiovascular stress and no need of prior EGD or mouth-to-nose transfer of the ENBD tube. However, a deliberate application is needed since its performance is difficult in some cases and is not feasible for some endoscopic treatments such as stenting. | Akihiro Mori Noritsugu Ohashi Takako Maruyama Hideharu Tatebe Katsuhisa Sakai Takashi Shibuya Hiroshi Inoue Shoudou Takegoshi Masataka Okuno | 2008 | World Journal of Gastroenterology2008，14，10： | 6 |
| 20 | STUDY ON THE TEXTURE OF A FRICTION STIR WELDED Mg-Al-Ca ALLOY显示文摘Macro-texture of an Mg-Al-Ca alloy prepared by friction stir welding (FSW) was investigated through pole figure measurement and X-ray diffraction (XRD) pattern analysis. It was found that at the top and bottom surfaces of friction stir zone (FSZ), (0002) basal planes of magnesium tend to be arranged parallel to the plate surface. In the cross section of FSZ, no obvious texture had evolved and (0002) basal planes showed a random distribution. | D. T. Zhang M. Suzuki K. Maruyama | 2006 | Acta Metallurgica Sinica(English Letters)2006，19，5： | 5 |
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