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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Role of Permanent Pacing to Prevent Atrial Fibrillation: Science Advisory From the American Heart Association Council on Clinical Cardiology (Subcommittee on Electrocardiography and Arrhythmias) and the Quality of Care and Outcomes Research Interdisciplin显示文摘 | Bradley P. Knight Bernard J. Gersh Mark D. Carlson Paul A. Friedman Robert L. McNamara S Adam Strickberger Hung Fat Tse Albert L. Waldo | 2005 | Circulation2005，，2： | 1 |
| 3 | Effect of permissive hypotension in conscious uncontrolled intra abdominal hemorrhage显示文摘 | S ilbergleit R Satz W Mcnamara RM | 1996 | A Cad Emerg Med1996，3，10： | 1 |
| 4 | A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes显示文摘 | Persaud-Sawin DA McNamara II JO Rylova S | 2004 | Pediatr Res2004，56，3： | 1 |
| 5 | The effect of biochar addition on N2O and CO2 emissions from a sandy loam soile-the role of soil aeration 显示文摘 | Case S D C Mcnamara N P Reay D S | 2012 | Soil Biolo- gy & Biochemistry2012，51，： | 1 |
| 6 | Crown depth and susceptibility to crown rot in wheat显示文摘 | Wildermuth G B McNamara R B Quick J S | 2001 | Euphytica2001，122，： | 1 |
| 7 | Triglyceride measurements: A review of methods and interferences显示文摘 | KLOTZSCH S G MCNAMARA J R | 1990 | Clin Chem1990，36，： | 1 |
| 8 | Improving Learning with eTextbooks显示文摘 | Dennis A R McNamara K O Morrone S | | 0，，： | 1 |
| 9 | Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice 显示文摘 | Linch S N Kasiewicz M J McNamara M J | 2016 | Proc Nail Acad Sci U S A2016，，3： | 1 |
| 10 | Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells 显示文摘 | Wang X Ge S McNamara G | 2003 | Blood2003，101，10： | 1 |
| 11 | Crown depth and susceptibility to crown rot in wheat显示文摘 | Wildermuth G B McNamara R B Quick J S | 2001 | Euphytica2001，122，： | 1 |
| 12 | Acute corticosterone replacement reinstates performance on spatial and nonspatial memory tasks 3 months after adrenalectomy despite degeneration in the dentate gyrus显示文摘 | McNamara M Mukhopadhyay S | 1997 | Behav Neurosci1997，111，3： | 1 |
| 13 | Mandibular morphology in subjects with Class Ⅲ malocclusions: Finite-element morphometry显示文摘 | Singh GB Mcnamara Jr JA Lozanoff S | 1998 | Angle Orthod1998，68，： | 1 |
| 14 | Sonoluminescence temperatures during multi-bubble cavitation显示文摘 | MCNAMARA W B DIDENKO Y T SUSLICK K S | | 0，，： | 1 |
| 15 | Id family of transcription factors and vascular lesion formation显示文摘 | Forrest S McNamara C | 2004 | Arterioscler Thromb Vasc Biol2004，24，11： | 1 |
| 16 | Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis 显示文摘 | MCNAMARA P S FLANAGAN B F HART C A | 2004 | Lancet2004，363，27： | 1 |
| 17 | Pressure during sonoluminescence显示文摘 | MCNAMARA III W B DIDENKO Y T SUSLICK K S | 2003 | Journal of Physics Chemistry B2003，107，30： | 1 |
| 18 | Production of ehemokines in the lungs of infants with severe respiratory syneytial virus bronehiolitis显示文摘 | MCNAMARA P S FLANAGAN B F HART C A | 2005 | J Infect Dis2005，191，8： | 1 |
| 19 | Effects of thyroxine and growth hormone treatment of dairy cows on milk yield,cardiac output and mammary blood flow显示文摘 | Davis S R Collier R J McNamara J P | 1988 | J Anim Sci1988，66，1： | 1 |
| 20 | A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway显示文摘 | McNamara B P and Donnenberg M S | 1998 | FEMS Microbiol Lett1998，166，： | 1 |
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