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| 1 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 2 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 3 | Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology显示文摘Cleft lip with or without cleft palate(CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and palate develop in a very characteristic way. For ultrasonographers involved in screening these patients it is crucial to have a thorough understanding of the embryology of the face. This could help them to make a more accurate diagnosis and save time during the ultrasound. Subsequently, the current postnatal classification will be discussed to facilitate the communication with the CP teams. | Bram Smarius Charlotte Loozen Wendy Manten Mireille Bekker Lou Pistorius Corstiaan Breugem | 2017 | World Journal of Methodology2017，7，3： | 15 |
| 4 | MRI-determined fat content of human liver,pancreas and kidney显示文摘AIM:To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight.METHODS:Magnetic resonance spectroscopy and a previously validated gradient echo magnetic resonance imaging method with Dixon's two point technique were used in this study to quantify fat in liver,pancreas as well as kidney.RESULTS:In 36 volunteers with body mass index(BMI) ranging from 20.0 to 42.9 kg/m2,the median fat content of liver,pancreas and kidney was 2.3%(interquartile range:0.2%-7.8%),2.7%(1.0%-6.5%) and 0.7%(0.1%-1.4%),respectively.BMI and subcutaneous fat correlated significantly with liver and pancreas fat content.We show for the first time the significant correlation of liver and pancreas fat content in healthy controls(r = 0.43,P < 0.01).These observations are related to body weight as measured by BMI and the amount of subcutaneous fat.Kidney fat content is very low and correlates with none of the other fat depots.CONCLUSION:Renal lipid accumulation,unlike the coupled accumulations of fat in liver and pancreas,is not observed in obese subjects.Unlike suggestions made in previous studies,renal lipid accumulation appears not to be involved in the pathogenesis of renal disease in humans. | Paul E Sijens Mireille A Edens Stephan JL Bakker Ronald P Stolk | 2010 | World Journal of Gastroenterology2010，16，16： | 14 |
| 5 | 自动驾驶与未来城市发展显示文摘采用自动驾驶技术的车辆不久就会闯入城市的街道和我们的生活。就像智能手机一样,它的特点也决定了这种技术将会迅速大规模地传播。新旧世界的更替是不可避免的。聚焦于自动驾驶车辆的到达与空间的行动响应和城市规划间的联系。对应于这场交通变革时代前夕,这里主要从两个视角进行论述:一是关于近期自动驾驶车辆使用的条件分析;二是未来自动驾驶车辆使用对城市空间规划和建设的挑战。 | Jean-Pierre Orfeuil Mireille Apel-Muller 祖源源 | 2018 | 上海城市规划2018，，2： | 11 |
| 6 | Natural hydroxyanthraquinoid pigments as potent food grade colorants:an overview显示文摘Natural pigments and colorants are widely used in the world in many industries such as textile dying,food processing or cosmetic manufacturing.Among the natural products of interest are various compounds belonging to carotenoids,anthocyanins,chlorophylls,melanins,betalains...The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature,the first one ever published.Trends in consumption,production and regulation of natural food grade colorants are given,in the current global market.The second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds,their properties and their biosynthetic pathways.Main natural sources of such pigments are summarized,followed by discussion about toxicity and carcinogenicity observed in some cases.As a conclusion,current industrial applications of natural hydroxyanthraquinoids are described with two examples,carminic acid from an insect and Arpink red^(™)from a filamentous fungus. | Yanis CARO Linda ANAMALE Mireille FOUILLAUD Philippe LAURENT Thomas PETIT Laurent DUFOSSE | 2012 | Natural Products and Bioprospecting2012，2，5： | 8 |
| 7 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 8 | 102例HIV-1感染者病毒株反转录酶基因多态性及耐药性变异研究显示文摘目的:目前中国未接受或已接受反转录酶抑制剂(RTI)治疗的HIV感染者的HIV反转录酶基因类型的数据较少。本研究探讨了HIV-1反转录酶的基因多态性,及在RTI选择性压力下出现的已知和未知变异位点。方法:分析研究21例未接受治疗及81例接受RTI治疗的HIV感染者的RT基因。大部分感染者(>80%)应用司他夫定(d4T)+地达诺新(ddI)+奈韦拉平(NVP)或d4T+拉米夫定(3TC)+依菲韦仑(EFV)三联HAART治疗方案。结果:在未接受治疗的患者中,发现了4个高度多态性位点(122、200、207和211)。在接受RTI治疗的患者中,发现了2种耐药相关变异(RAMs):①接受ddI+d4T+NVP治疗方案的患者中发现,K65R(9.8%)、L74V(7.4%)、M184V(7.4%)、Q151M(5%)和胸腺嘧啶类似物变异(TAMs)(9.3%),包括T215Y(5.5%);②接受d4T+3TC+EFV治疗方案的患者中发现,T215Y(23%)、M184V(20%)和TAMs(15.4%)。在所有病例中,非核苷反转录酶抑制剂(NNRTI)RAM的出现率很高(41.9%),而在142、221、224和228位点发现了4种可疑的新RAMs。结论:目前中国非核苷类反转录酶抑制剂(NNRTI)耐药相关变异十分普遍,本研究描述了RTI选择性变异的基因模式,提出了新的一些变异与RTI治疗的相关性。 | 刘莉 张云智 卢洪洲 Mireille Henry Catherine Tamalet | 2007 | 诊断学理论与实践2007，6，3： | 5 |
| 9 | 暴力与屠杀:刑法上的“敌人”还是刑法上的“不人道”显示文摘法律对屠杀问题的回应,始终在两种模式之间徘徊:一种是以国家刑法为给养来源的'刑法上的敌人'模式,另一种是源于国际刑法的'刑法上的不人道'模式。后者更适合屠杀的定性标准,它暗示了在大量死难者面前,对人性的否定。建立'刑法上的不人道'模式需要回应三个方面的问题:第一,罪的含义;第二,归责;第三,惩罚的实质。首先,根据《国际刑事法院规约》第7条,我们至少可以认为反人道模式中被保护的'人性'包含着两个相辅相成的要素:每个人的特殊性,以及每个人都平等地归属于人类共同体。其次,在归责问题上,我们不能满足于只制裁处于权力链条最顶端的人,还必须考虑等级体系的所有级别。最后在惩罚实质上,我们不仅要在刑罚制裁上考虑惩罚的本质,而且还需要从修复以及协商的角度看待这一问题。文章最后指出,刑法上的不人道模式成为一个可以实现的、普世的理想,尚需国际法与国内法的合作以及各个学科之间的协力。 | Mireille Delmas Marty 余履雪(译) | 2010 | 法学家2010，，4： | 4 |
| 10 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 11 | Molecular phylogeny of Trametes and related genera,and description of a new genus Leiotrametes显示文摘A phylogenetic analysis of Trametes and related taxa is proposed,based on a wide sampling of temperate and tropical species.Concatenate sequences of ribosomal DNA(ITS1-5.8S-ITS2)and RPB2 gene from mycelia cultures were analyzed by Maximum Likelihood and Bayesian methods,whilst morphological features were documented from the corresponding herbarium vouchers.Congruent results were obtained from analyses of ribosomal LSU sequences downloaded from Genbank.The Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and revealed the existence of three main lineages in the Trametes-clade:1)a monospecific lineage represented by Artolenzites elegans 2)a lineage including the genus Pycnoporus in its traditional sense and several species usually classified in the genus Trametes(T.cingulata,T.lactinea,T.ljubarskyi,T.menziesii)&3)a lineage corresponding to the core genus Trametes,including type species of Trametes,Coriolopsis and Lenzites.The presence of a pseudostipe,aspect and structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hydroxide and topography of pigments on skeletal hyphae gave relevant morphological support to these clades.When the structure of the hymenial surface,presence of a black line below the tomentum and color of context(except for genus Pycnoporus)usually used in traditional polypore-classifications did not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clade is proposed,with the introduction of a new genus:Leiotrametes Welti&Courtec.gen.nov..Two new combinations:Leiotrametes lactinea(Berk.)Welti&Courtec.comb.nov.and L.menziesii(Berk.)Welti&Courtec.comb.nov.are proposed. | Stéphane Welti Pierre-Arthur Moreau Anne Favel Régis Courtecuisse Mireille Haon David Navarro Sabine Taussac Laurence Lesage-Meessen | 2012 | Fungal Diversity2012，，4： | 3 |
| 12 | Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives显示文摘 | Valérie Planat-Benard Jean-Sébastien Silvestre Béatrice Cousin Mireille André Maryse Nibbelink Radia Tamarat Michel Clergue Carole Manneville Corinne Saillan-Barreau Micheline Duriez Alain Tedgui Bernard Levy Luc Pénicaud Louis Casteilla | 2004 | Circulation: Journal of the American Heart Association2004，，5： | 2 |
| 13 | Acute Severe Isovolemic Anemia Impairs Cognitive Function and Memory in Humans显示文摘 | Richard B. Weiskopf Joel H. Kramer Maurene Viele Mireille Neumann John R. Feiner Jessica J. Watson Harriet W. Hopf Pearl Toy | 2000 | Anesthesiology2000，，6： | 2 |
| 14 | Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?显示文摘 | Shahid A. Khan Shireen Emadossadaty Nimzing G. Ladep Howard C. Thomas Paul Elliott Simon D. Taylor-Robinson Mireille B. Toledano | 2011 | Journal of Hepatology2011，，4： | 2 |
| 15 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 2 |
| 16 | Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters显示文摘 | Florent G. Revel Michel Saboureau Mireille Masson-Pévet Paul Pévet Jens D. Mikkelsen Valérie Simonneaux | 2006 | Current Biology2006，，17： | 2 |
| 17 | GM-CSF and SDF treatment induced neovasculogenesis in a mouse ischemic hindlimb model显示文摘 | Mireille AM Mark B Todd G | 2004 | Am Coll Surg2004，199，3： | 1 |
| 18 | Purification and characterization of an anti- (A+B) speeic lectin from the mushroom Hygrophorus hypothejus 显示文摘 | Bertrand Veau Jean Guillot Mireille Damez | 1999 | Biochimica et Biophysica Acta1999，，1428： | 1 |
| 19 | Factors affecting university–industry R&D projects: The importance of searching, screening and signalling显示文摘 | Roberto Fontana Aldo Geuna Mireille Matt | 2005 | Research Policy2005，，2： | 1 |
| 20 | Export Processing Zones inMadagascar:a Success Story under Threat显示文摘 | Jean-Pierre Cling Mireille Razafindrakoto and Franc Ois Roubaud | 2005 | World Development2005，33，5： | 1 |
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